scholarly journals Comparison of Lipid Lowering Effect of Aqueous Extract of Cinnamon (Cinnamomum Cassiae) with that of Rosuvastatin on Experimentally Induced Hypercholesterolaemic Rats

2019 ◽  
Vol 31 (1) ◽  
pp. 52-61
Author(s):  
Sagia Afrose ◽  
Md Ismail Khan ◽  
Elisa Omar Eva ◽  
Mohammad Imtiaj Mahbub
Keyword(s):  
Serum Lipid ◽  
Lipid Level ◽  
Serum Lipid Level ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
P Value ◽  
High Cholesterol ◽  
Lowering Effect ◽  
Lipid Lowering Effect ◽  
Experimentally Induced

Background: Hypercholesterolemia is a condition characterized by very high level of cholesterol in the blood. Too much cholesterol increases risk of developing heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the coronary arteries that supply blood to the heart. A phenolic compound of the cinnamon extract lowers serum lipid level by inhibiting HMG COA reductase & by activation of nuclear receptor peroxisome proliferator activated receptor alpha (PPAR-α). We are trying to evaluate the lipid lowering effect of cinnamon (Cinnamomum cassiae) in comparison with rosuvastatin in hypercholesterolaemic rats. Aim: To find out the lipid lowering effect of aqueous extract of cinnamon (Cinnamomum cassiae) and compare it with a established lipid lowering drug (rosuvastatin) on hypercholesterolaemic rats. Method: This was a experimental study conducted in the department of Pharmacology, Dhaka medical college & Hospital from July 2015 to June 2016. Sample size was 30.The study was designed as 2 parts: Experiment-1 & Experiment -2. Result: Cinnamon produces no statistically significant effect on serum lipid level of healthy rats (P- value >0.05; which is not significant). Cinnamon significantly reduced serum lipid level of high cholesterol diet induced hypercholesterolaemic rats. But, there is statistically significant difference between cinnamon and rosuvastatin lipid lowering effect in high cholesterol diet induced hypercholesterolaemic rats (p value <0.05; which is significant). Conclusion: The study was conducted to find out lipid lowering effect of cinnamon on experimentally induced hypercholesterolaemic rats. The present study found that cinnamon (Cinnamomum cassaiae) significantly lowers serum lipid level in experimentally induced hypercholesterolaemic rats. So cinnamon can be used as alternative lipid lowering agent for its easy availability, cost effectiveness and as well as lack of significant side effects. TAJ 2018; 31(1): 52-61

Lipid-Lowering Effect of Eriocitrin, the Main Flavonoid in Lemon Fruit, in Rats on a High-Fat and High-Cholesterol Diet

2006 ◽  
Vol 71 (9) ◽  
pp. S633-S637 ◽  
Author(s):  
Yoshiaki Miyake ◽  
Eriko Suzuki ◽  
Satoko Ohya ◽  
Syuichi Fukumoto ◽  
Masanori Hiramitsu ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Lemon Fruit ◽  
Lowering Effect ◽  
Lipid Lowering Effect

scholarly journals Effect of Ethanol Extract of Glycine Max (Soy Bean) on Serum Lipid Profile of Fat-Fed Hyperlipidemic Rats

2018 ◽  
Vol 10 (1) ◽  
pp. 21-26
Author(s):  
K Sharmin ◽  
R Ahmed ◽  
A Momtaz ◽  
SA Chowdhury ◽  
NA Maya ◽  
...  
Keyword(s):  
Glycine Max ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Experimentally Induced

Hypercholesterolemia is one of the important causes of cardiovascular disease related mortality and morbidity and recently it has become a significant issue in public health problem of developing countries. The purpose of the study was to see the effect of glycine max (soy bean) on serum lipid profile of experimentally induced hyperlipidemic rats. Hypercholesterolemia was induced by high cholesterol diet containing 1% cholesterol in olive oil. This study was done on 24 long Norwegian rats (Rattus norvegicus) weighing about 200-210 gram. For convenience, the study was divided into Experiment I and Experiment II. In experiment I, 12 rats were divided into two groups- Group A (n = 6, control group) fed on laboratory diet and Group B (n=6) fed on laboratory diet and soy bean extract for 35 days. In experiment II, the remaining 12 rats were divided into 2 groups, Group C (n=6) were fed on laboratory diet and high cholesterol diet (HCD) for 35 days and Group D (n=6) were fed laboratory diet and high cholesterol diet on initial 10 days and soy bean extract was added along with high cholesterol diet for next 25 days. Serum TC, TG, LDL-C and HDL-C were measured after 35 days. HCD increased TG, TC and LDL-C significantly in group C. Glycine max (soy bean) treated group showed that it decreased plasma TC, TG and LDL-C in experimentally induced hyperlipidemic rats but Glycine max (soy bean) did not show any significant lipid lowering effect in normolipidemic rats. The results of this experimental study indicate that Glycine max can act as a cholesterol lowering agent and thereby can improve cardiovascular functions.Bangladesh J Med Biochem 2017; 10(1): 21-26

scholarly journals Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol Diet

2009 ◽  
Vol 46 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Thamolwan Suanarunsawat ◽  
Watcharaporn Devakul Na Ayutthaya ◽  
Thanapat Songsak ◽  
Suwan Thirawarapan ◽  
Somlak Poungshompoo
Keyword(s):  
Antioxidant Activity ◽  
Essential Oils ◽  
Lipid Lowering ◽  
Ocimum Sanctum ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Lowering Effect ◽  
Lipid Lowering Effect

Assessment of lipid lowering effect ofSida rhomboidea.Roxbmethanolic extract in experimentally induced hyperlipidemia

2009 ◽  
Vol 1 (3) ◽  
pp. 233 ◽  
Author(s):  
RV Devkar ◽  
AV Ramachandran ◽  
DK Patel ◽  
KA Patel ◽  
UK Patel ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
Lowering Effect ◽  
Lipid Lowering Effect ◽  
Experimentally Induced

Serum lipid-lowering effect of vinca alkaloids

1979 ◽  
Vol 28 (2) ◽  
pp. 227-230 ◽  
Author(s):  
T. Kremmer ◽  
L. Holczinger ◽  
Susan Somfai-Relle
Keyword(s):  
Serum Lipid ◽  
Lipid Lowering ◽  
Vinca Alkaloids ◽  
Lowering Effect ◽  
Lipid Lowering Effect

scholarly journals Pineapple consumption reduced cardiac oxidative stress and inflammation in high cholesterol diet-fed rats

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Porrnthanate Seenak ◽  
Sarawut Kumphune ◽  
Wachirawadee Malakul ◽  
Ratanon Chotima ◽  
Nitirut Nernpermpisooth
Keyword(s):  
Oxidative Stress ◽  
Serum Lipid ◽  
Lipid Profiles ◽  
Lipid Lowering ◽  
Ananas Comosus ◽  
In Vivo Model ◽  
High Cholesterol Diet ◽  
Potential Candidate ◽  
Cholesterol Diet ◽  
High Cholesterol

Abstract Background Hypercholesterolemia is a major risk factor for cardiovascular disease. It has been reported that pineapple contains healthy nutrients and phytochemicals associated with antioxidant and anti-inflammatory capacities. No investigation exists concerning the effect of pineapple consumption modulating hypercholesterolemia-induced cardiac damage in high-cholesterol diet (HCD)-fed rats. This study evaluated the effect of pineapple consumption on lipid-lowering, cardiac oxidative stress and inflammation in HCD-fed rats. Methods Male Sprague–Dawley rats were fed with HCD, in the presence and absence of Pineapple (Ananas comosus L.) cv. Pattavia powder for 8 weeks. Then, serum lipid profiles, liver and renal function tests, cardiac oxidative stress and pro-inflammatory cytokines were determined. Results Daily pineapple consumption reduced weight gain, serum lipid profiles, atherogenic coefficient (AC), cardiac risk ratio (CRR), and liver enzyme activity, without causing renal dysfunction. Pineapple consumption also restores cardiac protein carbonyl (cPC) content, reduces cardiac malondialdehyde (MDA), cardiac pro-inflammation cytokine IL-6 and IL-1β levels. Conclusion Pineapple possesses antioxidant and lipid-lowering properties and daily consumption alleviates hypercholesterolemia-induced cardiac lipid peroxidation and pro-inflammation elevation in an in vivo model. This study demonstrates that pineapple is a potential candidate for cardioprotection against hypercholesterolemia.

scholarly journals High cholesterol diet effects on ischemia–reperfusion injury of the heart

2012 ◽  
Vol 90 (9) ◽  
pp. 1185-1196 ◽  
Author(s):  
Verónica D’Annunzio ◽  
Martín Donato ◽  
Bruno Buchholz ◽  
Virginia Pérez ◽  
Verónica Miksztowicz ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Developed Countries ◽  
Lipid Lowering ◽  
Stunned Myocardium ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Lipid Lowering Effect

Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia–reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related to its development, of which hypercholesterolemia is one of the main ones. Therefore, the objective of this review was to elucidate the effects of a high-cholesterol diet on normal ventricular function and ischemia–reperfusion injury associated phenomenon such as post-ischemic ventricular dysfunction (stunned myocardium). Although there exist many studies considering several aspects of this physiopathological entity, the majority were carried out on normal animals. Thus, experiments carried out on hypercholesterolemic models are controversial, in particular those evaluating different mechanisms of cardioprotection such as ischemic preconditioning and postconditioning, and cardioprotection granted by drugs such as statins, which apart from exerting a lipid-lowering effect, exert pleiotropic effects providing cardioprotection against ischemia–reperfusion injury. These controversial results concerning the mechanisms of cardioprotection vary according to quality, composition, and time of administration of the high-cholesterol diet, as well as the species used in each experiment. Thus, to compare the results it is necessary to take all of these variables into account, since they can change the obtained results.

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