scholarly journals Effect of Ethanol Extract of Glycine Max (Soy Bean) on Serum Lipid Profile of Fat-Fed Hyperlipidemic Rats

2018 ◽  
Vol 10 (1) ◽  
pp. 21-26
Author(s):  
K Sharmin ◽  
R Ahmed ◽  
A Momtaz ◽  
SA Chowdhury ◽  
NA Maya ◽  
...  
Keyword(s):  
Glycine Max ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Experimentally Induced

Hypercholesterolemia is one of the important causes of cardiovascular disease related mortality and morbidity and recently it has become a significant issue in public health problem of developing countries. The purpose of the study was to see the effect of glycine max (soy bean) on serum lipid profile of experimentally induced hyperlipidemic rats. Hypercholesterolemia was induced by high cholesterol diet containing 1% cholesterol in olive oil. This study was done on 24 long Norwegian rats (Rattus norvegicus) weighing about 200-210 gram. For convenience, the study was divided into Experiment I and Experiment II. In experiment I, 12 rats were divided into two groups- Group A (n = 6, control group) fed on laboratory diet and Group B (n=6) fed on laboratory diet and soy bean extract for 35 days. In experiment II, the remaining 12 rats were divided into 2 groups, Group C (n=6) were fed on laboratory diet and high cholesterol diet (HCD) for 35 days and Group D (n=6) were fed laboratory diet and high cholesterol diet on initial 10 days and soy bean extract was added along with high cholesterol diet for next 25 days. Serum TC, TG, LDL-C and HDL-C were measured after 35 days. HCD increased TG, TC and LDL-C significantly in group C. Glycine max (soy bean) treated group showed that it decreased plasma TC, TG and LDL-C in experimentally induced hyperlipidemic rats but Glycine max (soy bean) did not show any significant lipid lowering effect in normolipidemic rats. The results of this experimental study indicate that Glycine max can act as a cholesterol lowering agent and thereby can improve cardiovascular functions.Bangladesh J Med Biochem 2017; 10(1): 21-26

Comparative Effect of Garden Egg Fruit, Oat and Apple on Serum Lipid Profile in Rats Fed a High Cholesterol Diet

2005 ◽  
Vol 4 (4) ◽  
pp. 245-249 ◽  
Author(s):  
James Karho Edijala . ◽  
Samuel Ogheneovo Asa . ◽  
George Edaghogho Eri . ◽  
Uzezi Atomatofa .
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Comparative Effect

scholarly journals Effect of lutein on lipid profile in hypercholesterolemic rats

2018 ◽  
Vol 7 (5) ◽  
pp. 859
Author(s):  
Uma Narayanamurthy ◽  
Anandhi M. ◽  
Manimekalai K.
Keyword(s):  
Fatty Infiltration ◽  
Treated Group ◽  
Lipid Lowering ◽  
Ldl Oxidation ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Chow Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Group I

Background: Hyperlipidemia or Dyslipidemia is the major cause of atherosclerosis1 and associated conditions. Low levels of high-density-lipoprotein cholesterol (HDL-C) are the major causes of increased atherogenic risk 1. Aggressive cholesterol reduction in patients with atherosclerotic disease is now the standard of care2. In addition to life style modification, patients with risk factors need lipid lowering drug therapy. The drugs available now do not reduce LDL oxidation, and oxidative stress associated with hyperlipidemia. In recent years, antioxidants have been subjected to epidemiological studies4 that have related their consumption to a reduction in the incidence of oxidative damage related diseases.Methods: Hypercholesterolemia was induced in rats by administration of high cholesterol diet for 30 days in standard rat chow diet. Rats were divided into four groups of six each. Group-I and II with intake of normal diet and High cholesterol diet respectively. Group III and IV are given high cholesterol diet along with Lutein 50mg/kg and Atorvastatin 5mg/kg orally once daily respectively. At the end of 30 days animals were subjected to overnight fasting. Blood samples were drawn by retro-orbital puncture for biochemical analysis. The animals were sacrificed after thiopentone injection and liver and aorta were dissected out and processed for histopathological study and biochemical analysis.Results: Lutein treated group showed even more significant reduction in TBARS levels than the normal control group and Atorvastatin treated group. The efficacy of Lutein in slowing down the atherosclerosis and fatty infiltration of liver is proved in this study.Conclusions: Hence the present study had shown significant hypolipidemic, antiatherogenic and antioxidant effect of Luetin in Hyperlipidemic rats. 

scholarly journals Effect of green tea on obesity and serum lipid profiles in both normo- and hyper-cholesterolemic rabbits

2019 ◽  
Vol 10 (2) ◽  
pp. 1035-1041
Author(s):  
Dlawer Abdulhammed Ahmad AL-Jaff
Keyword(s):  
Body Weight ◽  
Green Tea ◽  
Serum Lipid ◽  
Lipid Profiles ◽  
The Body ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Group I

Obesity has been linked with several comorbidities like cardiovascular disorders, diabetes, and hypertension. Weight reduction is directly associated with the consumption of green tea. So, with this premise of background, we evaluated the potential of green tea consumption on obesity and serum lipid profiles in both normo- and hyper-cholesterol emic rabbits. Sixty New Zealand white rabbits (age: 6-8 months; weight 1.5-2 kg) were used for this experiment. Rabbits were randomized and equally divided into three different groups. Group I (control group) received 10 ml/kg of distilled water twice daily, Group II received high cholesterol diet twice daily, and Group III received high cholesterol diet along with green tea solution 10 ml/kg, twice daily for 90 days. Weight measurements and serum analysis were conducted on Day 0 and day 90. For the obtained data, SPSS analysis was performed (SPSS 21). A significant increment of body weight was observed in control (1.97 ± 0.12 vs 2.87 ± 0.21, p<0.0001) and high cholesterol groups (1.91 ± 0.23 vs 3.13 ± 0.31, p<0.0001) at Day 90 when compared with Day 0. Though the results were not significant, there was a reduction in the body weight in the green tea group (2.20 ± 1.47 vs 1.72 ± 0.22) at Day 90 when compared with Day 0. Consumption of green tea for 90 days resulted in weight loss and inhibition of the increase in the levels of TC, LDL, and VLDL. So, green tea can act as a natural food supplement for the management of obesity and dyslipidemia.

scholarly journals Lipid-Lowering and Antioxidative Activities of Aqueous Extracts ofOcimum sanctumL. Leaves in Rats Fed with a High-Cholesterol Diet

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Thamolwan Suanarunsawat ◽  
Watcharaporn Devakul Na Ayutthaya ◽  
Thanapat Songsak ◽  
Suwan Thirawarapan ◽  
Somlak Poungshompoo
Keyword(s):  
Lipid Profile ◽  
Bile Acids ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Ocimum Sanctum ◽  
High Cholesterol ◽  
Leaf Extracts ◽  
Cardiac Tissues ◽  
High Level

The present study was conducted to investigate the lipid-lowering and antioxidative activities ofOcimum sanctumL. (OS) leaf extracts in liver and heart of rats fed with high-cholesterol (HC) diet for seven weeks. The results shows that OS suppressed the high levels of serum lipid profile and hepatic lipid content without significant effects on fecal lipid excretion. Fecal bile acids excretion was increased in HC rats treated with OS. The high serum levels of TBARS as well as AST, ALT, AP, LDH, CK-MB significantly decreased in HC rats treated with OS. OS suppressed the high level of TABARS and raised the low activities of GPx and CAT without any impact on SOD in the liver. As for the cardiac tissues, OS lowered the high level of TABARS, and raised the activities of GPx, CAT, and SOD. Histopathological results show that OS preserved the liver and myocardial tissues. It can be concluded that OS leaf extracts decreased hepatic and serum lipid profile, and provided the liver and cardiac tissues with protection from hypercholesterolemia. The lipid-lowering effect is probably due to the rise of bile acids synthesis using cholesterol as precursor, and antioxidative activity to protect liver from hypercholesterolemia.

scholarly journals Pineapple consumption reduced cardiac oxidative stress and inflammation in high cholesterol diet-fed rats

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Porrnthanate Seenak ◽  
Sarawut Kumphune ◽  
Wachirawadee Malakul ◽  
Ratanon Chotima ◽  
Nitirut Nernpermpisooth
Keyword(s):  
Oxidative Stress ◽  
Serum Lipid ◽  
Lipid Profiles ◽  
Lipid Lowering ◽  
Ananas Comosus ◽  
In Vivo Model ◽  
High Cholesterol Diet ◽  
Potential Candidate ◽  
Cholesterol Diet ◽  
High Cholesterol

Abstract Background Hypercholesterolemia is a major risk factor for cardiovascular disease. It has been reported that pineapple contains healthy nutrients and phytochemicals associated with antioxidant and anti-inflammatory capacities. No investigation exists concerning the effect of pineapple consumption modulating hypercholesterolemia-induced cardiac damage in high-cholesterol diet (HCD)-fed rats. This study evaluated the effect of pineapple consumption on lipid-lowering, cardiac oxidative stress and inflammation in HCD-fed rats. Methods Male Sprague–Dawley rats were fed with HCD, in the presence and absence of Pineapple (Ananas comosus L.) cv. Pattavia powder for 8 weeks. Then, serum lipid profiles, liver and renal function tests, cardiac oxidative stress and pro-inflammatory cytokines were determined. Results Daily pineapple consumption reduced weight gain, serum lipid profiles, atherogenic coefficient (AC), cardiac risk ratio (CRR), and liver enzyme activity, without causing renal dysfunction. Pineapple consumption also restores cardiac protein carbonyl (cPC) content, reduces cardiac malondialdehyde (MDA), cardiac pro-inflammation cytokine IL-6 and IL-1β levels. Conclusion Pineapple possesses antioxidant and lipid-lowering properties and daily consumption alleviates hypercholesterolemia-induced cardiac lipid peroxidation and pro-inflammation elevation in an in vivo model. This study demonstrates that pineapple is a potential candidate for cardioprotection against hypercholesterolemia.

scholarly journals Comparison of Lipid Lowering Effect of Aqueous Extract of Cinnamon (Cinnamomum Cassiae) with that of Rosuvastatin on Experimentally Induced Hypercholesterolaemic Rats

2019 ◽  
Vol 31 (1) ◽  
pp. 52-61
Author(s):  
Sagia Afrose ◽  
Md Ismail Khan ◽  
Elisa Omar Eva ◽  
Mohammad Imtiaj Mahbub
Keyword(s):  
Serum Lipid ◽  
Lipid Level ◽  
Serum Lipid Level ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
P Value ◽  
High Cholesterol ◽  
Lowering Effect ◽  
Lipid Lowering Effect ◽  
Experimentally Induced

Background: Hypercholesterolemia is a condition characterized by very high level of cholesterol in the blood. Too much cholesterol increases risk of developing heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the coronary arteries that supply blood to the heart. A phenolic compound of the cinnamon extract lowers serum lipid level by inhibiting HMG COA reductase & by activation of nuclear receptor peroxisome proliferator activated receptor alpha (PPAR-α). We are trying to evaluate the lipid lowering effect of cinnamon (Cinnamomum cassiae) in comparison with rosuvastatin in hypercholesterolaemic rats. Aim: To find out the lipid lowering effect of aqueous extract of cinnamon (Cinnamomum cassiae) and compare it with a established lipid lowering drug (rosuvastatin) on hypercholesterolaemic rats. Method: This was a experimental study conducted in the department of Pharmacology, Dhaka medical college & Hospital from July 2015 to June 2016. Sample size was 30.The study was designed as 2 parts: Experiment-1 & Experiment -2. Result: Cinnamon produces no statistically significant effect on serum lipid level of healthy rats (P- value >0.05; which is not significant). Cinnamon significantly reduced serum lipid level of high cholesterol diet induced hypercholesterolaemic rats. But, there is statistically significant difference between cinnamon and rosuvastatin lipid lowering effect in high cholesterol diet induced hypercholesterolaemic rats (p value <0.05; which is significant). Conclusion: The study was conducted to find out lipid lowering effect of cinnamon on experimentally induced hypercholesterolaemic rats. The present study found that cinnamon (Cinnamomum cassaiae) significantly lowers serum lipid level in experimentally induced hypercholesterolaemic rats. So cinnamon can be used as alternative lipid lowering agent for its easy availability, cost effectiveness and as well as lack of significant side effects. TAJ 2018; 31(1): 52-61

scholarly journals Effects of Repeatedly Heated Palm Oil on Serum Lipid Profile, Lipid Peroxidation and Homocysteine Levels in a Post-Menopausal Rat Model

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Siti Khadijah Adam ◽  
Ima Nirwana Soelaiman ◽  
Nor Aini Umar ◽  
Norhayati Mokhtar ◽  
Norazlina Mohamed ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Lipid Profile ◽  
Palm Oil ◽  
Serum Lipid ◽  
Unsaturated Fatty Acids ◽  
Thiobarbituric Acid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Cholesterol Diet ◽  
Sprague Dawley

Oxidized unsaturated fatty acids may contribute to the pathogenesis of atherosclerosis. In the present study, we examined the effects of heated palm oil mixed with 2% cholesterol diet on serum lipid profile, homocysteine and thiobarbituric acid reactive substances (TBARS) levels in estrogen-deficient rats. Twenty-four female Sprague Dawley rats were ovariectomized and then were divided equally into four groups. The control group was given 2% cholesterol diet only throughout the study period. The three treatment groups received 2% cholesterol diet fortified with fresh, once-heated or five-times-heated palm oil,respectively. Serum TBARS, lipid profile and homocysteine levels were measured prior to ovariectomy and at the end of four months of the study. Five-times-heated palm oil caused a significant increase in TBARS and total cholesterol (TC) compared to control (F = 22.529, p < 0.05). There was a significant increase in serum homocysteine in the control as well as five-times heated palm oil group compared to fresh and once-heated palm oil groups (F = 4.432, p < 0.05). The findings suggest that repeatedly heated palm oil increase lipid peroxidation and TC. Ovariectomy increases the development of atherosclerosis as seen in this study. Feeding with fresh and once-heated palm oil does not cause any deleterious effect but repeatedly heated oil may be harmful because it causes oxidative damage thereby predisposing to atherosclerosis.

scholarly journals Influence of technological processing on lipid-lowering activity of substances containing in porcine hearts and aortas

10.5219/1119 ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 331-336
Author(s):  
Elena Kotenkova ◽  
Irina Chernukha
Keyword(s):  
Molecular Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Raw Material ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Control Group ◽  
Standard Diet ◽  
Bioactive Substances ◽  
Wide Range

Edible by-products are a good source of nutrients and bioactive substances and could be used as functional ingredients or for biopeptides production natively contained in raw materials. A wide range of peptides are also formed during the enzymatic hydrolysis or food processing. The comparative results of the effectiveness of isolated certain protein and peptide fractions by ultrafiltration with the same natively presented in raw tissues, as well as the influence of heat treatment on biological activity of origin active substances are presented. The model of rat alimentary hyperlipidemia was developed by adding cholesterol and fat to the standard diet and vitamin D2 injection per os. Serum lipid profile was determined on automatic analyzer BioChem FC-360. Dynamic of changes in serum lipid profile was assessed as corresponding control group medium results in ratio to certain rat data. Two-dimensional electrophoresis (2DE) was performed according to the method of O’Farrell with isoelectric focusing in ampholine pH gradient (IEF-PAGE) with following identification by MALDI-TOF MS and MS/MS mass spectrometry. Consumption of native pig aorta and pig heart during 14th days led to normalization of lipid profile in serum of hyperlipidemic rats, while low molecular weight (LMUF, MW <5 kDa) and medium molecular weight (MMUF, MW = 5 – 30 kDa) ultrafiltrates of pig aorta extract did not strongly influenced on level of triglicerides and, on contrary, elevated high density cholesterol. Consumption of developed product by hyperlipidemic rats during 28th days did not lead to significant changes in serum lipid profile, while on 42nd day all ratios reached ones in group, which were treated with native raw material or isolated active fractions. The stability of developed product was confirmed by proteomic studies. Obtained results open prospects to modernization the technology, presumably use as a matrix dietary meat (e.g. poultry) with incorporated active identified components.

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