Coronary arterial disease associated with arteriosclerosis in lower extremity: angiographic analysis

Objectives: We research risk factors of chronic occlusive arterial disease of lower extremity. Subjects and methods: From 05/2010 to 04/2012, prospective study at Department of Thoracic and Cardiovascular Surgery of Hue Centre hospital, we have performed 49 patients in 30 males and 19 females from 33 to 92 ages, who were treated chronic occlusive arterial disease of lower extremity. Results: Majority of patients came to hospital with severe condition in grade III and IV according to Leriche-Fontain standards (27.12% and 66.1%). All patients incomed, expect the unmodifiable risk factor (as age, sex), we found socialty risk factor remarable (as hypertension 51.1%, smoking 18.36%, diabetes 10.2%, high cholesterol level 4.08%. Conclusions: Expect the unmodifiable risk factor, we found a the most striking association with hypertension, smoking, diabetes, high cholesterol level.

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Retraction Note: Association of severity of coronary artery disease by SYNTAX score (SS) and lower extremity arterial disease by duplex ultrasound (DUS) study—an Indian perspective

The Egyptian Heart Journal ◽

10.1186/s43044-020-00130-9 ◽

2020 ◽

Vol 72 (1) ◽

Author(s):

Saumen Nandi ◽

Anindya Mukherjee ◽

Dibbendhu Khanra ◽

Kaushik Biswas

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Lower Extremity ◽

Duplex Ultrasound ◽

Arterial Disease ◽

Syntax Score ◽

Lower Extremity Arterial Disease ◽

Retraction Notice ◽

Artery Disease ◽

Indian Perspective

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s43044-020-00091-z.

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Omega-3 Polyunsaturated Fatty Acid Supplementation in Patients with Lower Extremity Arterial Disease

Journal of the American College of Nutrition ◽

10.1080/07315724.2021.1891155 ◽

2021 ◽

pp. 1-9

Author(s):

Min-I Su ◽

Ying-Chih Cheng ◽

Yu-Chen Huang ◽

Cheng-Wei Liu

Keyword(s):

Fatty Acid ◽

Lower Extremity ◽

Polyunsaturated Fatty Acid ◽

Arterial Disease ◽

Omega 3 ◽

Lower Extremity Arterial Disease ◽

Fatty Acid Supplementation ◽

Acid Supplementation

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Urinary fatty acid binding protein 3 (uFABP3) is a potential biomarker for peripheral arterial disease

Scientific Reports ◽

10.1038/s41598-021-90395-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Abdelrahman Zamzam ◽

Muzammil H. Syed ◽

John Harlock ◽

John Eikelboom ◽

Krishna K. Singh ◽

...

Keyword(s):

Fatty Acid ◽

Fatty Acid Binding Protein ◽

Binding Protein ◽

Arterial Disease ◽

Prior History ◽

P Value ◽

Fatty Acid Binding ◽

Coronary Arterial Disease ◽

Acid Binding Protein ◽

Potential Biomarker

AbstractPlasma levels of fatty acid binding protein 3 (pFABP3) are elevated in patients with peripheral artery disease (PAD). Since the kidney filters FABP3 from circulation, we investigated whether urinary fatty acid binding protein 3 (uFABP3) is associated with PAD, and also explored its potential as a diagnostic biomarker for this disease state. A total of 130 patients were recruited from outpatient clinics at St. Michael’s Hospital, comprising of 65 patients with PAD and 65 patients without PAD (non-PAD). Levels of uFABP3 normalized for urine creatinine (uFABP3/uCr) were 1.7-folds higher in patients with PAD [median (IQR) 4.41 (2.79–8.08)] compared with non-PAD controls [median (IQR) 2.49 (1.78–3.12), p-value = 0.001]. Subgroup analysis demonstrated no significant effect of cardiovascular risk factors (age, sex, hypertension, hypercholesteremia, diabetes and smoking) on uFABP3/uCr in both PAD and non-PAD patients. Spearmen correlation studies demonstrated a significant negative correlation between uFABP3/uCr and ABI (ρ = − 0.436; p-value = 0.001). Regression analysis demonstrated that uFABP3/Cr levels were associated with PAD independently of age, sex, hypercholesterolemia, smoking, prior history of coronary arterial disease and Estimated Glomerular Filtration rate (eGFR) [odds ratio: 2.34 (95% confidence interval: 1.47–3.75) p-value < 0.001]. Lastly, receiver operator curve (ROC) analysis demonstrated unadjusted area under the curve (AUC) for uFABP3/Cr of 0.79, which improved to 0.86 after adjusting for eGFR, age, hypercholesteremia, smoking and diabetes. In conclusion, our results demonstrate a strong association between uFABP3/Cr and PAD and suggest the potential of uFABP3/Cr in identifying patients with PAD.

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Diagnostic Performance of Ankle-Brachial Pressure Index in Lower Extremity Arterial Disease

The Surgery Journal ◽

10.1055/s-0041-1731444 ◽

2021 ◽

Vol 07 (03) ◽

pp. e132-e137

Author(s):

Mohammed Alagha ◽

Thomas M. Aherne ◽

Ahmed Hassanin ◽

Adeel S. Zafar ◽

Doireann P. Joyce ◽

...

Keyword(s):

Lower Extremity ◽

Sensitivity And Specificity ◽

False Negative ◽

Arterial Disease ◽

Initial Assessment ◽

Reference Standard ◽

Lower Extremity Arterial Disease ◽

Negative Results ◽

Positive Results ◽

Arterial Imaging

Abstract Introduction Ankle-brachial pressure indices (ABIs) continue to form the basis of diagnostics for lower extremity arterial disease (LEAD). However, there remains a paucity of data to support its accuracy. This study aims to evaluate its diagnostic sensitivity and specificity using established arterial-imaging modalities as a benchmark. Methods In this retrospective study, a regional, prospectively maintained, vascular laboratory database was interrogated to identify referred patients with arterial disease who underwent concomitant assessment with ABI and lower limb arterial duplex ultrasound (DUS). Duplex acted as the reference standard. Those who had peripheral computed tomography angiogram (CTA) within 3 months of initial assessment were included in a subgroup analysis to correlate ABI with CTA. The primary end point was the sensitivity and specificity of ABI compared with DUS as the reference standard. Results Concomitant assessment was performed in 438 limbs (250 patients) over a 27-month period. The ABI was normal (0.9 to 1.4) in 196 limbs (44.9%) and abnormal in the remaining 241 limbs (55.1%). False-positive results occurred in 83 out of 241 limbs (34.4%), and false-negative results occurred in 54 limbs out of 196 (27.5%). True-positive results were 158 out of 241 limbs (65.6%), whereas true-negative results were 142 out of 196 limbs (72.4%). ABI using DUS as a benchmark identified a sensitivity for peripheral artery disease of 72.3% and a specificity of 69.3%. Concomitant CTA imaging was available in 200 limbs. The sensitivity and specificity of ABI correlated with CTA were 65.5 and 68.8%, respectively. Conclusion ABIs have a moderate predictive value in the diagnosis of LEAD. Normal range outcomes cannot be taken to infer the absence of LEAD and, as such, further arterial imaging in the form of DUS or angiography should be strongly considered in those with suspected underlying disease requiring intervention. Further noninvasive tests such as exercise studies or pulse volume waveforms should be considered, if diagnostic uncertainty exists, in those requiring nonoperative intervention and risk factor control.

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