Differential Diagnosis of Malignant Ovarian Tumors on CT Findings

Abstract Objective.—Anti–inhibin α and inhibin/activin βA subunit and anti-CD99 monoclonal antibodies (mAbs) have recently been demonstrated to be able to label ovarian granulosa cells; thus, they may be of value in the diagnosis of granulosa cell tumors. The present study aimed to determine what combination of these mAbs may be useful for the differential diagnosis of sex cord–stromal tumors of ovary. Design.—Immunohistochemical analyses with anti–inhibin α and inhibin/activin βA subunit antibody and anti-CD99 mAb were performed on 42 ovarian tumors, including sex cord–stromal tumors (29), ovarian epithelial cancers (10), and Krukenberg tumors (3). Results.—All sex cord–stromal tumors were positive for inhibin α subunit, and 17 cases (58.6%) of sex cord–stromal tumors were immunoreactive for inhibin/activin βA subunit. Epithelial tumors and Krukenberg tumors were all negative for inhibin/activin βA subunit except mucinous carcinoma, which showed strong cytoplasmic immunoreactivity. All sex cord–stromal tumors except one granulosa cell tumor showed membranous staining for CD99. A case of serous carcinoma and a case of mucinous carcinoma were positive for CD99, and the remaining epithelial tumors and Krukenberg tumor were all negative for CD99. Conclusions.—The results of immunohistochemical analysis, together with literature review, suggest that inhibin α subunit may be a useful diagnostic marker for sex cord–stromal tumor of the ovary. In addition, anti-CD99 antibody may be useful for the differential diagnosis between ovarian tumors. Inhibin/activin βA subunit has a limited usefulness in the differential diagnosis of ovarian tumor because of its wider immunoreactivity for both sex cord–stromal tumors and mucinous carcinomas. The differential diagnosis of sex cord–stromal tumors of the ovary would be better made with a combined use of both anti–inhibin α subunit and anti-CD99 mAbs.

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Non-perforated peptic ulcer disease: multidetector CT findings, complications, and differential diagnosis

Insights into Imaging ◽

10.1007/s13244-017-0562-5 ◽

2017 ◽

Vol 8 (5) ◽

pp. 455-469 ◽

Cited By ~ 7

Author(s):

Massimo Tonolini ◽

Anna Maria Ierardi ◽

Elena Bracchi ◽

Paolo Magistrelli ◽

Adriana Vella ◽

...

Keyword(s):

Differential Diagnosis ◽

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Multidetector Ct ◽

Perforated Peptic Ulcer ◽

Ulcer Disease ◽

Ct Findings

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Spectropolarimetry in the differential diagnosis of benign and malignant ovarian tumors

Thirteenth International Conference on Correlation Optics ◽

10.1117/12.2303946 ◽

2018 ◽

Author(s):

Sergey B. Yermolenko ◽

Olexander P. Peresunko ◽

Ion Gruia

Keyword(s):

Differential Diagnosis ◽

Ovarian Tumors

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Diagnosis and Management of Ovarian Tumor in Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome

BioMed Research International ◽

10.1155/2018/2369430 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6

Author(s):

Yali Miao ◽

Jirui Wen ◽

Liwei Huang ◽

Jiang Wu ◽

Zhiwei Zhao

Keyword(s):

Differential Diagnosis ◽

Laparoscopic Surgery ◽

Conservative Management ◽

Ovarian Tumor ◽

Imaging Techniques ◽

Clinical Findings ◽

Ovarian Tumors ◽

Mrkh Syndrome ◽

Diagnosis And Management ◽

Relevant Case

In the most recent publications on Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, the uterine remnants and ovaries in patients may develop uterine remnant leiomyoma, adenomyosis, or ovarian tumor, and this can lead to problems in differential diagnosis. Here we summarize the diagnosis methods and available interventions for ovarian tumor in MRKH syndrome, with emphasis on the relevant clinical findings and illustrative relevant case. According to the clinical findings and illustrative relevant case, with the help of imaging techniques, ovarian tumors can be detected in the pelvis in patients with MRKH syndrome and evaluated in terms of size. Laparoscopy could further differentiate ovarian tumors into different pathological types. In addition, laparoscopic surgery not only is helpful for the diagnosis of MRKH combined ovarian tumor, but also has a good treatment role for excising ovarian tumor at the same time. Moreover, laparoscopic removals of ovarian tumor can be considered as a safe and reliable treatment for conservative management.

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P1099 Differential diagnosis of malignant ovarian tumors - use of advanced data mining systems for classification making processes

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(09)62583-2 ◽

2009 ◽

Vol 107 ◽

pp. S720-S720

Author(s):

A. Smolen ◽

A. Czekierdowski ◽

N. Stachowicz ◽

M. Kotarska ◽

J. Kotarski

Keyword(s):

Data Mining ◽

Differential Diagnosis ◽

Ovarian Tumors

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FSH and LH serum/tumor fluid ratios and malignant tumors of the ovary.

Endocrine Related Cancer ◽

10.1677/erc.0.0110315 ◽

2004 ◽

Vol 11 (2) ◽

pp. 315-321 ◽

Cited By ~ 23

Author(s):

I Rzepka-G√≥rska ◽

A Chudecka-G≈Çaz ◽

B Kosmowska

Keyword(s):

Ovarian Cancer ◽

Differential Diagnosis ◽

Malignant Tumors ◽

Ovarian Tumors ◽

Predictive Values ◽

Epithelial Tumors ◽

Ovarian Carcinogenesis ◽

Benign Ovarian Tumors ◽

Sensitivity Specificity

The aim of this work was to compare mean concentrations of gonadotropins in serum and fluid from malignant and benign ovarian tumors. We enrolled 126 patients diagnosed with malignant epithelial tumors (n=40), borderline epithelial tumors (n=14), benign cystadenomas (n=28) and simple cysts (n=44) of the ovary. Premenopausal and postmenopausal subgroups were formed in each group. The concentration of FSH and LH was measured in serum and tumor fluid and the serum/tumor fluid ratio was calculated. The results in each group were compared and the sensitivity, specificity, positive and negative predictive values were determined. Mean concentrations of both gonadotropins in ovarian cancer fluid were significantly higher than in the remaining groups (P ranged from <0.005 to <0.0001). Mean serum/fluid ratios were lowest in ovarian cancer (FSH=2.91, LH=4.19). Our findings support the hypothesis that gonadotropins are involved in ovarian carcinogenesis and suggest that gonadotropin serum/tumor fluid ratios could be of value in the differential diagnosis of functional and organic cysts of the ovary.

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