scholarly journals Lower Omega-3 Index Is a Marker of Increased Propensity of Hypertensive Rat Heart to Malignant Arrhythmias

2013 ◽  
pp. S201-S208 ◽  
Author(s):  
B. BAČOVÁ ◽  
P. SEČ ◽  
J. RADOŠINSKÁ ◽  
M. ČERTÍK ◽  
A. VACHULOVÁ ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Rat Heart ◽  
Wistar Rats ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Pufa Intake ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
Total Fatty Acids ◽  
Malignant Arrhythmias

Polyunsaturated omega-3 fatty acids (ω-3 PUFA) are important components of cell membrane affecting its function and their deficiency is deleterious to health. We have previously shown that spontaneously hypertensive rats (SHR) are prone to lifethreatening arrhythmias that are reduced by ω-3 PUFA intake. Purpose of this study was to explore plasma and red blood cells (RBC) profile of ω-3 and ω-6 PUFA as well as to determine ω-3 index, a risk factor for sudden cardiac death, in aged SHR and the effect of ω-3 PUFA intake. Male and female 12-month-old SHR and age-matched Wistar rats fed with ω-3 PUFA (200 mg/kg BW/day/2 month) were compared with untreated rats. Composition of ω-3 PUFA: alfa linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as ω-6 PUFA: linoleic acid and arachidonic acid was analyzed by gas chromatography. Results showed sex- and strain-related differences of basal ω-3 and ω-6 PUFA levels in plasma and RBC as well as in response to ω-3 PUFA intake. Comparing to Wistar rats ω-3 index, expressed as a percentage of EPA+DHA of total fatty acids, was lower in SHR and it increased due to consumption of ω-3 PUFA. Findings support our hypothesis that lower ω-3 index may be also a marker of increased propensity of the hypertensive rat heart to malignant arrhythmias.

Effects of omega-3 fatty acids and sugar on attention in the spontaneously hypertensive rat

2018 ◽  
Vol 48 ◽  
pp. 676-681 ◽  
Author(s):  
Joachim Hauser ◽  
Ewelina Stollberg ◽  
Andreas Reissmann ◽  
Ivo Kaunzinger ◽  
Klaus W. Lange
Keyword(s):  
Fatty Acids ◽  
Spontaneously Hypertensive Rat ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Cardioprotective effects of omega 3 fatty acids from fish oil and it enhances autoimmunity in porcine cardiac myosin-induced myocarditis in the rat model

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ling-Yan Li ◽  
Xu Wang ◽  
Ting-Chuan Zhang ◽  
Zong-Jun Liu ◽  
Jun-Qing Gao
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Inflammatory Cells ◽  
Omega 3 Fatty Acids ◽  
Cardiac Myosin ◽  
Omega 3 ◽  
Autoimmune Myocarditis ◽  
Tuna Fish ◽  
Fame Analysis ◽  
Total Fatty Acids

Abstract This experiment proposed to investigate the efficiency of omega 3 fatty acids from fish that improves autoimmune against myocarditis in the rat. Fish oil was extracted from fresh Tuna fish and performed FAME analysis and mice bioassay. The autoimmune myocarditis was induced by subcutaneous injection of porcine cardiac myosin (PCM) into the footpads of rats on the first and seventh day. Rats were dissected on the 21st day to analyze the histopathological, hemodynamic, echocardiographic factors, and immunohistochemistry expressions. In the study, 73.90% of total fatty acids were recorded. Histological analysis revealed that omega 3 fatty acids administrated groups showed tremendous development in the multifocal myocardia hyaline degeneration and necrosis with inflammatory changes. Moreover, omega 3 fatty acids inhabited the expressions of inflammatory cells (CD4, CD8 and CD11b) and suppressed the level of NF-κB. The echocardiographic factors such as heartbeat, SBP, DBP, levels of LVDs, LVDd, LVPW percentage of LVFS, EF, expression levels of inflammatory cytokines (TNF, IL-1β, IFN-ɤ, IL-2, and IL-6) also significantly suppressed by omega 3 fatty acids. Hence, the present study proved that consuming fatty acid-enriched fish might be a successful therapy for improving the inflammatory profile, regenerates the heart tissues, and controlled the production of inflammatory cells.

scholarly journals Maternal Pre-Pregnancy Obesity Attenuates Response to Omega-3 Fatty Acids Supplementation During Pregnancy

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1908 ◽  
Author(s):  
Carmen Monthé-Drèze ◽  
Annie Penfield-Cyr ◽  
Marcela Smid ◽  
Sarbattama Sen
Keyword(s):  
Fatty Acids ◽  
Maternal Obesity ◽  
Secondary Analysis ◽  
Systemic Response ◽  
Omega 3 Fatty Acids ◽  
Obese Women ◽  
Omega 3 ◽  
Maternal Fetal Medicine ◽  
Inflammatory Status ◽  
Total Fatty Acids

Maternal obesity is associated with adverse offspring outcomes. Inflammation and deficiency of anti-inflammatory nutrients like omega(n)-3 polyunsaturated fatty acids (PUFA) may contribute to these associations. Fetal supply of n-3 PUFA is dependent on maternal levels and studies have suggested that improved offspring outcomes are associated with higher maternal intake. However, little is known about how maternal obesity affects the response to n-3 supplementation during pregnancy. We sought to determine (1) the associations of obesity with PUFA concentrations and (2) if the systemic response to n-3 supplementation differs by body mass index (BMI). This was a secondary analysis of 556 participants (46% lean, 28% obese) in the Maternal-Fetal Medicine Units Network trial of n-3 (Docosahexaenoic acid (DHA) + Eicosapentaenoic acid (EPA)) supplementation, in which participants had 2g/day of n-3 (n = 278) or placebo (n = 278) from 19 to 22 weeks until delivery. At baseline, obese women had higher plasma n-6 arachidonic acid concentrations (β: 0.96% total fatty acids; 95% Confidence Interval (CI): 0.13, 1.79) and n-6/n-3 ratio (β: 0.26 unit; 95% CI: 0.05, 0.48) compared to lean women. In the adjusted analysis, women in all BMI groups had higher n-3 concentrations following supplementation, although obese women had attenuated changes (β = −2.04%, CI: −3.19, −0.90, interaction p = 0.000) compared to lean women, resulting in a 50% difference in the effect size. Similarly, obese women also had an attenuated reduction (β = 0.94 units, CI: 0.40, 1.47, interaction p = 0.046) in the n-6/n-3 ratio (marker of inflammatory status), which was 65% lower compared to lean women. Obesity is associated with higher inflammation and with an attenuated response to n-3 supplementation in pregnancy.

scholarly journals Modulation of Systemic and Aortic Nitric Oxide by Melatonin and n-3 Polyunsaturated Fatty Acids in Isoproterenol Affected Spontaneously Hypertensive and Normotensive Wistar Rats

2016 ◽  
pp. S109-S118 ◽  
Author(s):  
K. K. CHAUDAGAR ◽  
C. VICZENCZOVA ◽  
B. SZEIFFOVA BACOVA ◽  
T. EGAN BENOVA ◽  
M. BARANCIK ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Wistar Rats ◽  
Dependent Manner ◽  
Pufa Supplementation ◽  
Pufa Intake ◽  
Spontaneously Hypertensive ◽  
No Release ◽  
Strain Dependent

We aimed to explore the effects of melatonin and n-3 polyunsaturated fatty acids (PUFA) supplementation on plasma and aortic nitric oxide (NO) levels in isoproterenol (Iso) affected spontaneously hypertensive (SHR) and Wistar rats. Untreated control rats were compared with Iso injected (118 mg/kg, s.c.) rats, and Iso injected plus supplemented with melatonin (10 mg/kg, p.o.) or PUFA (1.68 g/kg, p.o.) for two months. Plasma and aortic basal, L-NAME inhibited, adrenaline and acetylcholine stimulated NO were determined using Griess method. Plasma NO levels were lower in SHR versus Wistar rats. Iso decreased NO in Wistar while not in SHR. PUFA but not melatonin intake of Iso treated SHR increased plasma NO along with a decrease in systolic blood pressure. Basal aortic NO level was higher in SHR than Wistar rats and not altered by Iso. Intake of melatonin increased but PUFA decreased basal NO levels in Wistar+Iso and did not affect in SHR+Iso rats. Acetylcholine and adrenaline induced aortic NO release was significantly increased in Wistar+Iso but not SHR+Iso group. Melatonin intake increased Ach induced aortic NO in Wistar+Iso and SHR+Iso groups, whereas there was no effect of PUFA intake. Findings suggest that PUFA modulates plasma and melatonin aortic NO levels of isoproterenol affected rats in a strain-dependent manner.

Omega-3 fatty acids moderate oxidative and proinflammatory events in experimental hepatotoxicity in Wistar rats: comparison with livolin

Synergy ◽  
2018 ◽  
Vol 7 ◽  
pp. 17-24 ◽  
Author(s):  
Luqman Aribidesi Olayaki ◽  
Wale Johnson Adeyemi ◽  
Joseph Sunday Yinusa ◽  
Grace Amarachi Adedayo
Keyword(s):  
Fatty Acids ◽  
Wistar Rats ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Myocardial NOS activity and connexin-43 expression in untreated and omega-3 fatty acids-treated spontaneously hypertensive and hereditary hypertriglyceridemic rats

2010 ◽  
Vol 347 (1-2) ◽  
pp. 163-173 ◽  
Author(s):  
Jana Radosinska ◽  
Barbara Bacova ◽  
Iveta Bernatova ◽  
Jana Navarova ◽  
Anna Zhukovska ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Connexin 43 ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Spontaneously Hypertensive

scholarly journals Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats

2015 ◽  
Vol 42 (6) ◽  
pp. 393-397 ◽  
Author(s):  
Rosilda Mendes da Silva ◽  
Osvaldo Malafaia ◽  
Orlando Jorge Martins Torres ◽  
Nicolau Gregori Czeczko ◽  
Carlos Hespanha Marinho Junior ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Liver Regeneration ◽  
Wistar Rats ◽  
Statistical Difference ◽  
Histological Study ◽  
Liver Weight ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Serum Aspartate Aminotransferase ◽  
Significant Interference

Objective: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. Methods: thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, and mitosis of the liver stained with H&E. Results: the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups. Conclusion: supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.

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