scholarly journals Plasma Levels of Glial Cell Marker S100B in Children With Autism

2019 ◽  
pp. S315-S323 ◽  
Author(s):  
A. TOMOVA ◽  
P. KEMÉNYOVÁ ◽  
D. FILČÍKOVÁ ◽  
Ž. SZAPUOVÁ ◽  
A. KOVÁČ ◽  
...  
Keyword(s):  
Glial Cells ◽  
Plasma Levels ◽  
Calcium Binding ◽  
Plasma Concentrations ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Behavioral Symptoms ◽  
Cell Marker ◽  
Exact Role ◽  
Enteric Glial Cells

Autism spectrum disorder (ASD) is a neurodevelopmental condition with increasing incidence. Recent evidences suggest glial cells involvement in autism pathophysiology. S100B is a calcium binding protein, mainly found in astrocytes and therefore used as a marker of their activity. In our study, children with autism had higher plasma concentrations of S100B compared to non-autistic controls. No association of S100B plasma levels with behavioral symptoms (ADI-R and ADOS-2 scales) was found. Plasma S100B concentration significantly correlated with urine serotonin, suggesting their interconnection. Correlation of plasma S100B levels with stool calprotectin concentrations was found, suggesting not only brain astrocytes, but also enteric glial cells may take part in autism pathogenesis. Based on our findings, S100B seems to have a potential to be used as a biomarker of human neurodevelopmental disorders, but more investigations are needed to clarify its exact role in pathomechanism of autism.

scholarly journals Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Joanna C. Hamlin ◽  
Margaret Pauly ◽  
Stepan Melnyk ◽  
Oleksandra Pavliv ◽  
William Starrett ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Research Network ◽  
Control Group ◽  
Lower Plasma ◽  
One Carbon Metabolism ◽  
Positive Correlations

Abnormalities in folate-dependent one-carbon metabolism have been reported in many children with autism. Because inadequate choline and betaine can negatively affect folate metabolism and in turn downstream methylation and antioxidant capacity, we sought to determine whether dietary intake of choline and betaine in children with autism was adequate to meet nutritional needs based on national recommendations. Three-day food records were analyzed for 288 children with autism (ASDs) who participated in the national Autism Intervention Research Network for Physical Health (AIR-P) Study on Diet and Nutrition in children with autism. Plasma concentrations of choline and betaine were measured in a subgroup of 35 children with ASDs and 32 age-matched control children. The results indicated that 60–93% of children with ASDs were consuming less than the recommended Adequate Intake (AI) for choline. Strong positive correlations were found between dietary intake and plasma concentrations of choline and betaine in autistic children as well as lower plasma concentrations compared to the control group. We conclude that choline and betaine intake is inadequate in a significant subgroup of children with ASDs and is reflected in lower plasma levels. Inadequate intake of choline and betaine may contribute to the metabolic abnormalities observed in many children with autism and warrants attention in nutritional counseling.

Plasma concentrations of the trace elements copper, zinc and selenium in Brazilian children with autism spectrum disorder

2018 ◽  
Vol 106 ◽  
pp. 605-609 ◽  
Author(s):  
Paula Fabiana Saldanha Tschinkel ◽  
Geir Bjørklund ◽  
Lourdes Zélia Zanoni Conón ◽  
Salvatore Chirumbolo ◽  
Valter Aragão Nascimento
Keyword(s):  
Autism Spectrum Disorder ◽  
Trace Elements ◽  
Plasma Concentrations ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Copper Zinc ◽  
Brazilian Children

Elevated plasma levels of glutamate in children with autism spectrum disorders

Neuroreport ◽  
2016 ◽  
Vol 27 (4) ◽  
pp. 272-276 ◽  
Author(s):  
Jing Cai ◽  
Li Ding ◽  
Jin-Shan Zhang ◽  
Jie Xue ◽  
Ling-Zhang Wang
Keyword(s):  
Autism Spectrum Disorders ◽  
Plasma Levels ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Elevated Plasma ◽  
Spectrum Disorders

scholarly journals Little is known about cannabidiol for improving severe behavioral symptoms of autistic spectrum disorder

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Keerteshwrya Mishra
Keyword(s):  
Autism Spectrum Disorder ◽  
Autistic Spectrum Disorder ◽  
Children With Autism ◽  
Clinical Decision ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Behavioral Symptoms ◽  
Autistic Spectrum

A clinical decision report appraising Barchel D, Stolar O, De-Haan T, et al. Oral cannabidiol use in children with autism spectrum disorder to treat related symptoms and co-morbidities. Frontiers in Pharmacology. 2019;9. https://doi.org/10.3389/fphar.2018.01521

scholarly journals Aberrant Development of Enteric Glial Cells in the Colon of Hirschsprung's Disease

2021 ◽  
Vol 9 ◽  
Author(s):  
Tingting Zhou ◽  
Wei Liu ◽  
Xiaofang Yu ◽  
Zengcai Cao ◽  
Weijing Mu ◽  
...  
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Glial Cells ◽  
Calcium Binding ◽  
Hirschsprung's Disease ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Acidic Protein ◽  
S100 Calcium Binding Protein ◽  
Enteric Glial Cells ◽  
Protein B

Objective: The aim of this study was to explore the development of enteric glial cells (EGCs) in different segments of Hirschsprung's disease (HSCR).Methods: Colonic specimens from 35 children with HSCR were selected to analyze the relative expression of glial fibrillary acidic protein and S100 calcium-binding protein B using Western blotting and real-time fluorescence quantitative PCR. Immunofluorescence and immunohistochemical staining were performed to determine the distribution of myenteric EGCs and neuronal cells in different segments of HSCR.Results: There was a trend of diminished protein and mRNA expression of glial fibrillary acidic protein and S100 calcium-binding protein B from the proximal, dilated, and transitional segments to the aganglionic segment (p < 0.05). Immunofluorescence and immunohistochemistry showed that the EGCs in the aganglionic, transitional, and dilated colonic muscles were morphologically abnormal, which was consistent with the dysplasia of myenteric neurons.Conclusion: Aberrant development of myenteric EGCs was observed in the colon of HSCR, which may affect the survival of enteric neurons.

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