scholarly journals Erratum for: Synergistic Antitumor Effect of BKM120 with Prima-1Met Via Inhibiting PI3K/AKT/mTOR and CPSF4/hTERT Signaling and Reactivating Mutant P53

2020 ◽  
Vol 54 (4) ◽  
pp. 794-796
Keyword(s):  
Antitumor Effect ◽  
Mutant P53 ◽  
Synergistic Antitumor Effect

Synergistic antitumor effect of ING4/PTEN double tumor suppressors mediated by adenovirus modified with arginine-glycine-aspartate on glioma

2020 ◽  
Vol 64 (2) ◽  
Author(s):  
Yaodong Zhao ◽  
Jiarong Wang ◽  
Jicheng Yang ◽  
Jingcheng Miao
Keyword(s):  
Tumor Suppressors ◽  
Antitumor Effect ◽  
Synergistic Antitumor Effect

Transcutaneous Tumor Vaccination Combined With aPD-1 Treatment Produces a Synergistic Antitumor Effect

2021 ◽  
Author(s):  
Xinran Song ◽  
Huoyan Hong ◽  
Gomaa El Fawal ◽  
Jinglei Wu ◽  
Di Jiang ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Tumor Vaccination ◽  
Synergistic Antitumor Effect

scholarly journals Synergistic antitumor effect of brusatol combined with cisplatin on colorectal cancer cells

2018 ◽  
Author(s):  
Hai‑Ming Chen ◽  
Zheng‑Quan Lai ◽  
Hui‑Jun Liao ◽  
Jian‑Hui Xie ◽  
Yan‑Fang Xian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Synergistic Antitumor Effect ◽  
Colorectal Cancer Cells

Synergistic antitumor effect of combining metronomic chemotherapy with adoptive cell immunotherapy in nude mice

Apmis ◽  
2014 ◽  
Vol 122 (5) ◽  
pp. 380-391 ◽  
Author(s):  
Shujing Shi ◽  
Leilei Tao ◽  
Haizhu Song ◽  
Longbang Chen ◽  
Guichun Huang
Keyword(s):  
Nude Mice ◽  
Antitumor Effect ◽  
Metronomic Chemotherapy ◽  
Synergistic Antitumor Effect ◽  
Cell Immunotherapy ◽  
Adoptive Cell Immunotherapy

Membrane Loaded Copper Oleate PEGylated Liposome Combined with Disulfiram for Improving Synergistic Antitumor Effect In Vivo

2018 ◽  
Vol 35 (7) ◽  
Author(s):  
Lingli Zhou ◽  
Liu Yang ◽  
Chulei Yang ◽  
Yi Liu ◽  
Qiuyue Chen ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Pegylated Liposome ◽  
Synergistic Antitumor Effect ◽  
Copper Oleate

931 Synergistic antitumor effect of satraplatin and NVP-BEZ235 in cisplatin-resistant human bladder cancer cells

2016 ◽  
Vol 15 (3) ◽  
pp. e931
Author(s):  
C.Y. Yoon ◽  
M.K. Kong ◽  
H.G. Ahn ◽  
S.G. Kang ◽  
J.H. Han ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Synergistic Antitumor Effect ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells

Synergistic antitumor effect of ionomycin and cisplatin against renal cell carcinoma in vitro and in vivo

Urology ◽  
2001 ◽  
Vol 57 (1) ◽  
pp. 188-192 ◽  
Author(s):  
Masayuki Okamoto ◽  
Isao Hara ◽  
Hideaki Miyake ◽  
Shoji Hara ◽  
Akinobu Gotoh ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Antitumor Effect ◽  
Synergistic Antitumor Effect

scholarly journals Synergistic Antitumor Effect of BKM120 with Prima-1Met Via Inhibiting PI3K/AKT/mTOR and CPSF4/hTERT Signaling and Reactivating Mutant P53

2018 ◽  
Vol 45 (5) ◽  
pp. 1772-1786 ◽  
Author(s):  
Zongjuan Li ◽  
Xiangdong Xu ◽  
Yizhuo Li ◽  
Kun Zou ◽  
Zhuo Zhang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Viability ◽  
Cancer Cells ◽  
Colony Formation ◽  
Antitumor Effect ◽  
Migration And Invasion ◽  
Mutant P53 ◽  
Stem Cell Markers ◽  
Combinational Treatment ◽  
Thyroid Cancer Cells

Background/Aims: PI3KCA and mutant p53 are associated with tumorigenesis and the development of cancers. NVP-BKM120, a selective pan-PI3K inhibitor, exerts the antitumor activity by suppressing the PI3K signaling pathway. Prima-1Met, a low molecular weight compound, can rescue the gain-of-function of mutant p53 by restoring its transcriptional function. In this study, we investigated whether PI3K inhibition combined with mutant p53 reactivation could enhance the antitumor effect in thyroid cancer cells. Methods: The effects of BKM120 and Prima-1Met on the proliferation, apoptosis, migration and invasion of thyroid cancer cells were measured by MTT, colony formation, flow cytometry, wound-healing and transwell assays, respectively. Thyroid differentiation was assessed by detecting the expression levels of specific markers using RT-PCR and Western blot. The in vivo antitumor efficacy was analyzed in a mouse xenograft model. Results: The combinational treatment of BKM120 and Prima-1Met significantly enhanced the inhibitions of cell viability, colony formation, migration and invasion, and the induction of apoptosis in thyroid cell lines, and synergistically suppressed tumor xenograft growth by inhibiting the PI3K/Akt/mTOR and EMT signaling pathways, up-regulating p53 targeted genes, and triggering the release of cytochrome c. Moreover, the combination of BKM120 and Prima-1Met suppressed the stemlike traits of thyroid cancer cells and promoted their differentiation by upregulating the expression of thyroid-specific differentiation markers and repressing the expression of cancer stem cell markers. Furthermore, the mechanism study demonstrated that the combinational treatment synergistically abrogated the binding of CPSF4 at the promoter of hTERT and thus suppressed hTERT expression. Consistently, overexpression of hTERT rescued the inhibitions of cell viability, invasion and stem-like traits mediated by the combination of BKM120 and Prima-1Met. Conclusion: Our results showed that the combination of BKM120 with Prima-1Met synergistically suppressed the growth of thyroid cancer cells and tumor xenografts via inhibiting PI3K/Akt/mTOR and CPSF4/hTERT signaling and reactivating mutant p53.

Abstract 4720: Synergistic antitumor effect of selinexor, a selective inhibitor of nuclear export (SINE) compound and panobinostat in a mouse model of multiple myeloma

2016 ◽  
Author(s):  
Sivan Elloul ◽  
Hua Chang ◽  
Boris Klebanov ◽  
Trinayan Kashyap ◽  
Maxwell Werman ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Mouse Model ◽  
Nuclear Export ◽  
Antitumor Effect ◽  
Selective Inhibitor ◽  
Synergistic Antitumor Effect

Abstract LB-206: The synergistic antitumor effect of the combination of three transgenes delivered by the oncolytic vaccinia virus, KLS-3020

2019 ◽  
Author(s):  
Jaeil Shin ◽  
Soon-Oh Hong ◽  
Minjung Kim ◽  
Heonsik Choi ◽  
Sujeong Kim
Keyword(s):  
Vaccinia Virus ◽  
Antitumor Effect ◽  
Synergistic Antitumor Effect
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