Post-infectious irritable bowel syndrome: renaissance time?

Postinfectious irritable bowel syndrome (PI–IBS) is a distinct phenotype of the disease. The occurrence of gastrointestinal symptoms in PI–IBS is in direct chronological connection with an episode of acute intestinal infection. Previously the problem was considered as the outcome of parasitic, protozoal or bacterial infection. The global spread of a novel coronavirus infection (COVID-19) and increase in the number of new cases of IBS in the population suggests a renaissance of PI–IBS and makes us look at this problem again. This article summarizes and presents modern information on the possible mechanisms of development of PI–IBS, including in persons who have undergone COVID-19.

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Post-infectious IBS: a New Look at an Old Problem

Effective Pharmacotherapy ◽

10.33978/2307-3586-2021-17-16-108-113 ◽

2021 ◽

Vol 17 (16) ◽

pp. 108-113

Author(s):

O.V. Gaus ◽

◽

M.A. Livzan

Keyword(s):

Irritable Bowel Syndrome ◽

Effective Therapy ◽

Intestinal Infection ◽

Viral Etiology ◽

High Prevalence ◽

Coronavirus Infection ◽

Irritable Bowel ◽

Mechanisms Of Development ◽

Post Infectious

The high prevalence and heterogeneity of irritable bowel syndrome (IBS), the lack of effective therapy regimens require the determination of individual phenotypes of the disease. One of the phenotypes is post-infectious IBS (PI-IBS) associated with an episode of acute intestinal infection of bacterial or viral etiology. Special pathogenetic factors are involved in the development of PI-IBS. This must be taken into account when treating patients in this group. This article provides up-to-date information on the mechanisms of development of PI-IBS, including after a new coronavirus infection

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Diarrhea syndrome: new accents of patient curation during COVID-19 pandemic

Russian Medical Inquiry ◽

10.32364/2587-6821-2021-5-6-446-452 ◽

2021 ◽

Vol 5 (6) ◽

pp. 446-452

Author(s):

O.V. Gaus ◽

◽

M.A. Livzan ◽

Keyword(s):

Irritable Bowel Syndrome ◽

Ischemic Colitis ◽

Clinical Manifestations ◽

Gastrointestinal Symptoms ◽

Gastrointestinal Disorder ◽

Infected People ◽

Antibiotic Associated Diarrhea ◽

Irritable Bowel ◽

Diarrhea Syndrome ◽

Post Infectious

The digestive tract, like the respiratory organs, is the entrance gate for SARS-CoV-2. At the same time, diarrhea is one of the most common gastrointestinal symptoms among infected people. As the debut of COVID-19 clinical manifestations, diarrhea can be associated both with the direct cytopathic effect of the virus on the intestinal mucosal epithelium and with the gut microbiota modulation. During the period of the expanded clinical picture of COVID-19, diarrhea syndrome is commonly associated with the adverse event of drug therapy, primarily antibiotics, nonsteroidal anti-inflammatory drugs, antiviral agents, antiplatelet agents and anticoagulants, as well as with possible involvement in the pathological process of the liver and pancreas with a violation of their functional activity. Finally, after the infection, the repeated occurrence of diarrhea requires the exclusion of antibiotic-associated diarrhea, including those caused by Clostridium difficile, as well as ischemic colitis and post-infectious irritable bowel syndrome. Besides, despite the pandemic, it should not be forgotten about the possible debut of gastrointestinal disorder or an exacerbation of already existing chronic pathology. The article presents a brief algorithm for the differential diagnosis of diarrhea in the conditions of the COVID-19 pandemic. KEYWORDS: diarrhea, COVID-19 pandemic, antibiotic-associated diarrhea, ischemic colitis, post-infectious irritable bowel syndrome. FOR CITATION: Gaus O.V., Livzan M.A. Diarrhea syndrome: new accents of patient curation during COVID-19 pandemic. Russian Medical Inquiry. 2021;5(6):446–452 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-446-452.

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Faculty Opinions recommendation of Improvement in gastrointestinal symptoms after cognitive behavior therapy for refractory irritable bowel syndrome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733117751.793555235 ◽

2019 ◽

Author(s):

Edith Ho

Keyword(s):

Irritable Bowel Syndrome ◽

Behavior Therapy ◽

Cognitive Behavior Therapy ◽

Gastrointestinal Symptoms ◽

Cognitive Behavior ◽

Irritable Bowel

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Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms

Scientific Reports ◽

10.1038/s41598-021-87158-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

L. Quénéhervé ◽

D. Drui ◽

J. Blin ◽

M. Péré ◽

E. Coron ◽

...

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Adrenal Insufficiency ◽

Gastrointestinal Symptoms ◽

Control Group ◽

Non Profit ◽

Acute Adrenal Insufficiency ◽

Irritable Bowel ◽

Rome Iv

AbstractGastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI). We aimed to characterize digestive symptoms in CAI patients. We used the section pertaining functional bowel disorders of the Rome IV questionnaire. A questionnaire was published on the website of the non-profit patient association “Adrenals” (NPPA of CAI patients) for five months. Information on demographics, characteristics of adrenal insufficiency, digestive symptoms and quality of life was collected. The relatives of CAI patients served as a control group. We analyzed responses of 33 control subjects and 119 patients (68 primary adrenal insufficiency (PAI), 30 secondary adrenal insufficiency (SAI) and 21 congenital adrenal hyperplasia (CAH)). Abdominal pain at least once a week over the past 3 months was reported by 40%, 47% and 33% of patients with PAI, SAI and CAH respectively versus 15% for the controls (p = 0.01). Symptoms were consistent with the Rome IV criteria for irritable bowel syndrome in 27%, 33% and 33% of patients respectively versus 6% for the controls (p < 0.0001). Quality of life was described as poor or very poor in 35%, 57% and 24% of patients respectively versus 5% for the controls (p < 0.0001). In conclusion, digestive symptoms are frequent and incapacitating in CAI patients and similar to symptoms of irritable bowel syndrome in 30% of CAI patients. Assessment and management of digestive symptoms should be considered a priority for physicians treating patients with CAI.

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NaHS inhibits NF-κB signal against inflammation and oxidative stress in post-infectious irritable bowel syndrome

RSC Advances ◽

10.1039/c6ra13849g ◽

2016 ◽

Vol 6 (69) ◽

pp. 64208-64214 ◽

Cited By ~ 2

Author(s):

Shenglan Yang ◽

Danfang Deng ◽

Yingying Luo ◽

Yanran Wu ◽

Rui Zhu ◽

...

Keyword(s):

Oxidative Stress ◽

Irritable Bowel Syndrome ◽

Hydrogen Sulfide ◽

Murine Model ◽

Irritable Bowel ◽

And Oxidative Stress ◽

Post Infectious

In this study, the alleviating role of hydrogen sulfide (H2S) was investigated in a Post-Infectious Irritable Bowel Syndrome (PI-IBS) murine model and Caco-2 cells.

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Irritable bowel syndrome in midlife women: a narrative review

Women s Midlife Health ◽

10.1186/s40695-021-00064-5 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Pei-Lin Yang ◽

Margaret M. Heitkemper ◽

Kendra J. Kamp

Keyword(s):

Irritable Bowel Syndrome ◽

Management Strategies ◽

Gastrointestinal Symptoms ◽

Midlife Women ◽

Pelvic Surgery ◽

Poor Sleep ◽

Hormonal Changes ◽

Seek Health Care ◽

Multiple Challenges ◽

Irritable Bowel

AbstractMidlife women between the ages of 40 and 65 years have reported multiple challenges due to menopausal, developmental, and situational transitions from younger to older adulthood. During the midlife period, many women seek health care for gastrointestinal symptoms and irritable bowel syndrome (IBS). Multiple factors including stress, poor sleep, diet, and physical inactivity may contribute to IBS or gastrointestinal symptoms in midlife women. As such, a comprehensive assessment and treatment approach is needed for midlife women suffering gastrointestinal symptoms. This article reviews the main aspects of the menopausal transition, sex hormonal changes, abdominal and pelvic surgery, psychosocial distress, behavioral factors, and gut microbiome, as well as their relevance on IBS and gastrointestinal symptoms in midlife women. Also, management strategies for IBS in midlife women are discussed. To date, gastrointestinal symptoms during midlife years remain a critical area of women’s health. Additional research is needed to better understand the contributors to gastrointestinal symptoms in this group. Such efforts may provide a new window to refine or develop treatments of gastrointestinal symptoms for midlife women.

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