scholarly journals Application of Mucosal Immune-related Molecular Adjuvants CCL19 and CCL28 in Enhancing the Function of HSV-2 gD DNA Vaccine

2021 ◽  
Vol 3 (6) ◽  
Keyword(s):  
Dna Vaccine ◽  
Molecular Adjuvants

scholarly journals Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model

Vaccines ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 42 ◽  
Author(s):  
Lumena Louis ◽  
Megan C. Wise ◽  
Hyeree Choi ◽  
Daniel O. Villarreal ◽  
Kar Muthumani ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Critical Role ◽  
Lethal Challenge ◽  
Synthetic Dna ◽  
Molecular Adjuvant ◽  
Immunodeficiency Virus ◽  
Suboptimal Dose ◽  
Dose Sparing ◽  
Molecular Adjuvants ◽  
Induced Immunity

Identification of novel molecular adjuvants which can boost and enhance vaccine-mediated immunity and provide dose-sparing potential against complex infectious diseases and for immunotherapy in cancer is likely to play a critical role in the next generation of vaccines. Given the number of challenging targets for which no or only partial vaccine options exist, adjuvants that can address some of these concerns are in high demand. Here, we report that a designed truncated Interleukin-36 gamma (IL-36 gamma) encoded plasmid can act as a potent adjuvant for several DNA-encoded vaccine targets including human immunodeficiency virus (HIV), influenza, and Zika in immunization models. We further show that the truncated IL-36 gamma (opt-36γt) plasmid provides improved dose sparing as it boosts immunity to a suboptimal dose of a Zika DNA vaccine, resulting in potent protection against a lethal Zika challenge.

scholarly journals Co-Administration of Molecular Adjuvants Expressing NF-Kappa B Subunit p65/RelA or Type-1 Transactivator T-bet Enhance Antigen Specific DNA Vaccine-Induced Immunity

Vaccines ◽  
2014 ◽  
Vol 2 (2) ◽  
pp. 196-215 ◽  
Author(s):  
Devon Shedlock ◽  
Colleen Tingey ◽  
Lavanya Mahadevan ◽  
Natalie Hutnick ◽  
Emma Reuschel ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Nf Kappa B ◽  
B Subunit ◽  
Molecular Adjuvants ◽  
Induced Immunity

Cytokine Molecular Adjuvants Modulate Immune Responses Induced by DNA Vaccine Constructs for HIV-1 and SIV

1999 ◽  
Vol 19 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Jong J. Kim ◽  
Kenneth A. Simbiri ◽  
Jeong I. Sin ◽  
Kesen Dang ◽  
Jim Oh ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Molecular Adjuvants ◽  
Hiv 1

scholarly journals Improvement of a DNA vaccine against BoHV-1 using chemical and molecular adjuvants

2015 ◽  
Vol 6 ◽  
Author(s):  
Gammella Mariela ◽  
Soria Ivana ◽  
Bellusci Carolina ◽  
Bidart Juan ◽  
Langellotti Cecilia ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Molecular Adjuvants

VHSV G glycoprotein major determinants implicated in triggering the host type I IFN antiviral response as DNA vaccine molecular adjuvants

Vaccine ◽  
2014 ◽  
Vol 32 (45) ◽  
pp. 6012-6019 ◽  
Author(s):  
A. Martinez-Lopez ◽  
P. Garcia-Valtanen ◽  
M. Ortega-Villaizan ◽  
V. Chico ◽  
E. Gomez-Casado ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Antiviral Response ◽  
Type I ◽  
Type I Ifn ◽  
Host Type ◽  
Molecular Adjuvants
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