scholarly journals De Novo Design of Type II Topoisomerase Inhibitors as Potential Antimicrobial Agents Targeting a Novel Binding Region

2021 ◽  
Author(s):  
Kyle Orritt ◽  
Juliette Newell ◽  
Thomas Germe ◽  
Lauren Abbott ◽  
Holly Jackson ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
De Novo ◽  
De Novo Design ◽  
Type Ii ◽  
Topoisomerase Inhibitors ◽  
Binding Region

Synthesis of novel PPARα/γ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design programprotobuild

2011 ◽  
Vol 9 (4) ◽  
pp. 1169-1188 ◽  
Author(s):  
Yushma Bhurruth-Alcor ◽  
Therese Røst ◽  
Michael R. Jorgensen ◽  
Christos Kontogiorgis ◽  
Jon Skorve ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
De Novo ◽  
De Novo Design ◽  
Diabetes Type ◽  
Type Ii ◽  
Diabetes Type Ii ◽  
The Metabolic Syndrome

scholarly journals Template-Based de Novo Design for Type II Kinase Inhibitors and Its Extended Application to Acetylcholinesterase Inhibitors

Molecules ◽  
2013 ◽  
Vol 18 (11) ◽  
pp. 13487-13509 ◽  
Author(s):  
Bo-Han Su ◽  
Yi-Syuan Huang ◽  
Chia-Yun Chang ◽  
Yi-Shu Tu ◽  
Yufeng Tseng
Keyword(s):  
Kinase Inhibitors ◽  
De Novo ◽  
Acetylcholinesterase Inhibitors ◽  
De Novo Design ◽  
Type Ii ◽  
Extended Application

Towards the de novo design of DNA based catalytic sites using a combined NMR and in silico approach

2014 ◽  
Author(s):  
Dieter Buyst ◽  
V. Gheerardijn ◽  
J. Van Den Begin ◽  
A. Madder ◽  
J. C. Martins
Keyword(s):  
In Silico ◽  
De Novo ◽  
De Novo Design ◽  
Catalytic Sites

scholarly journals De Novo Design of Selective Quadruplex‐Duplex Junction Ligands and Structural Characterisation of their Binding Mode: Targeting the G4 Hot‐Spot

2020 ◽  
Author(s):  
Laura Díaz-Casado ◽  
Israel Serrano-Chacón ◽  
Laura Montalvillo-Jiménez ◽  
Francisco Corzana ◽  
Agatha Bastida ◽  
...  
Keyword(s):  
De Novo ◽  
Hot Spot ◽  
Binding Mode ◽  
De Novo Design ◽  
Structural Characterisation

scholarly journals De novo design of modular and tunable protein biosensors

Nature ◽  
2021 ◽  
Author(s):  
Alfredo Quijano-Rubio ◽  
Hsien-Wei Yeh ◽  
Jooyoung Park ◽  
Hansol Lee ◽  
Robert A. Langan ◽  
...  
Keyword(s):  
De Novo ◽  
De Novo Design

scholarly journals Front Cover: De Novo Design of Selective Quadruplex–Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot‐Spot (Chem. Eur. J. 20/2021)

2021 ◽  
Vol 27 (20) ◽  
pp. 6101-6101
Author(s):  
Laura Díaz‐Casado ◽  
Israel Serrano‐Chacón ◽  
Laura Montalvillo‐Jiménez ◽  
Francisco Corzana ◽  
Agatha Bastida ◽  
...  
Keyword(s):  
De Novo ◽  
Hot Spot ◽  
Binding Mode ◽  
De Novo Design ◽  
Front Cover ◽  
Structural Characterisation

scholarly journals De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects

2021 ◽  
pp. 2101716
Author(s):  
Lizhen Xu ◽  
Heng Zhang ◽  
Yunfei Wang ◽  
Xiancui Lu ◽  
Zhenye Zhao ◽  
...  
Keyword(s):  
De Novo ◽  
De Novo Design ◽  
Allosteric Modulators ◽  
Analgesic Effects ◽  
Positive Allosteric Modulators
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