scholarly journals Role of cutatneous regulatory T cells in regulation of immune homeostasis and contact hypersensitivity reaction in the skin

2013 ◽  
Vol 4 ◽  
Author(s):  
Hanakawa Sho ◽  
Kitoh Akihiko ◽  
Miyachi Yoshiki ◽  
Kabashima Kenji
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Hypersensitivity Reaction ◽  
Contact Hypersensitivity ◽  
Immune Homeostasis

The Role of Regulatory T Cells in Contact Hypersensitivity

2010 ◽  
Vol 4 (2) ◽  
pp. 85-89 ◽  
Author(s):  
Tetsuya Honda ◽  
Yoshiki Miyachi ◽  
Kenji Kabashima
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity

scholarly journals IL18 signaling promotes homing of mature Tregs into the thymus

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Cristina Peligero-Cruz ◽  
Tal Givony ◽  
Arnau Sebé-Pedrós ◽  
Jan Dobeš ◽  
Noam Kadouri ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Chemokine Receptor ◽  
Suppressor Cells ◽  
Molecular Characteristics ◽  
Immune Homeostasis ◽  
Detailed Characterization ◽  
Major Subset

Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs populate the thymus and constitute a major subset of yet poorly understood cells. Here we describe a subset of thymus recirculating IL18R+ Tregs with molecular characteristics highly reminiscent of tissue-resident effector Tregs. Moreover, we show that IL18R+ Tregs are endowed with higher capacity to populate the thymus than their IL18R– or IL18R–/– counterparts, highlighting the key role of IL18R in this process. Finally, we demonstrate that IL18 signaling is critical for the induction of the key thymus-homing chemokine receptor – CCR6 on Tregs. Collectively, this study provides a detailed characterization of the mature Treg subsets in the mouse thymus and identifies a key role of IL18 signaling in controlling the CCR6-CCL20-dependent migration of Tregs into the thymus.

scholarly journals The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma – an immunohistochemical study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Satu Salmi ◽  
Anton Lin ◽  
Benjamin Hirschovits-Gerz ◽  
Mari Valkonen ◽  
Niina Aaltonen ◽  
...  
Keyword(s):  
T Cells ◽  
Prognostic Factors ◽  
Regulatory T Cells ◽  
Tumor Cells ◽  
Immune Cells ◽  
Positive Association ◽  
Tumor Stage ◽  
Melanoma Cells ◽  
Melanoma Progression

Abstract Background FoxP3+ Regulatory T cells (Tregs) and indoleamine-2,3-dioxygenase (IDO) participate in the formation of an immunosuppressive tumor microenvironment (TME) in malignant cutaneous melanoma (CM). Recent studies have reported that IDO expression correlates with poor prognosis and greater Breslow’s depth, but results concerning the role of FoxP3+ Tregs in CM have been controversial. Furthermore, the correlation between IDO and Tregs has not been substantially studied in CM, although IDO is known to be an important regulator of Tregs activity. Methods We investigated the associations of FoxP3+ Tregs, IDO+ tumor cells and IDO+ stromal immune cells with tumor stage, prognostic factors and survival in CM. FoxP3 and IDO were immunohistochemically stained from 29 benign and 29 dysplastic nevi, 18 in situ -melanomas, 48 superficial and 62 deep melanomas and 67 lymph node metastases (LNMs) of CM. The number of FoxP3+ Tregs and IDO+ stromal immune cells, and the coverage and intensity of IDO+ tumor cells were analysed. Results The number of FoxP3+ Tregs and IDO+ stromal immune cells were significantly higher in malignant melanomas compared with benign lesions. The increased expression of IDO in melanoma cells was associated with poor prognostic factors, such as recurrence, nodular growth pattern and increased mitotic count. Furthermore, the expression of IDO in melanoma cells was associated with reduced recurrence˗free survival. We further showed that there was a positive correlation between IDO+ tumor cells and FoxP3+ Tregs. Conclusions These results indicate that IDO is strongly involved in melanoma progression. FoxP3+ Tregs also seems to contribute to the immunosuppressive TME in CM, but their significance in melanoma progression remains unclear. The positive association of FoxP3+ Tregs with IDO+ melanoma cells, but not with IDO+ stromal immune cells, indicates a complex interaction between IDO and Tregs in CM, which demands further studies.

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