scholarly journals Identify Inflammatory Bowel Disease-Related Genes Based on Machine Learning

2021 ◽  
Vol 9 ◽  
Author(s):  
Lili Ye ◽  
Yongwei Lin ◽  
Xing-di Fan ◽  
Yaoming Chen ◽  
Zengli Deng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Genetic Factors ◽  
Cross Validation ◽  
Gene Interactions ◽  
High Risk Factors ◽  
Inflammatory Bowel ◽  
Disease Related Genes

The patients of Inflammatory bowel disease (IBD) are increasing worldwide. IBD has the characteristics of recurring and difficult to cure, and it is also one of the high-risk factors for colorectal cancer (CRC). The occurrence of IBD is closely related to genetic factors, which prompted us to identify IBD-related genes. Based on the hypothesis that similar diseases are related to similar genes, we purposed a SVM-based method to identify IBD-related genes by disease similarities and gene interactions. One hundred thirty-five diseases which have similarities with IBD and their related genes were obtained. These genes are considered as the candidates of IBD-related genes. We extracted features of each gene and implemented SVM to identify the probability that it is related to IBD. Ten-cross validation was applied to verify the effectiveness of our method. The AUC is 0.93 and AUPR is 0.97, which are the best among four methods. We prioritized the candidate genes and did case studies on top five genes.

scholarly journals Risk factors for developing high-output ileostomy: a retrospective study

2021 ◽  
Author(s):  
Xiao Jian'an ◽  
Dongxiao Bai ◽  
Lei Li ◽  
Zhiling Shen ◽  
Tianchen Huang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Total Colectomy ◽  
Neoadjuvant Chemoradiotherapy ◽  
Clear Correlation ◽  
Abdominal Infection ◽  
Inflammatory Bowel

Abstract Background Prophylactic ileostomy and colostomy have been widely used to reduce the risk and complications of anastomotic leakage with high-risk colorectal cancer after operation. However, prophylactic ileostomy itself has some complications, and ileostomy high out-put syndrome is one of them. This study was performed to explore the risk factors of HOS in ileostomy.Methods A total of 114 patients with HOS were screened out from 494 eligible ileostomy patients in the last five years. The clinical and pathological data were analyzed. The relationship between HOS and clinicopathological data was analyzed. Multivariate analysis was performed by logistic regression.Results There was no clear correlation between the occurrence of HOS with sex, age, gross typing, histological grade, location of tumors, lymph node metastasis and TNM stage (p>0.05). Preoperative complications including inflammatory bowel disease, diabetes mellitus and neoadjuvant chemoradiotherapy were risk factors for HOS (p<0.05). Total colectomy and abdominal infection were risk factors for HOS (p<0.05) during operation.Conclusion Inflammatory bowel disease, diabetes mellitus and neoadjuvant radiotherapy and chemotherapy in patients with colorectal cancer are the preoperative risk factors for HOS. Total colectomy and postoperative abdominal infection are the postoperative risk factors for HOS.

Colorectal cancer

2016 ◽  
pp. 444-477
Author(s):  
Alex Boussioutas ◽  
Stephen Fox ◽  
Iris Nagtegaal ◽  
Alexander Heriot ◽  
Jonathan Knowles ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Colon Cancer ◽  
Bowel Disease ◽  
Colonic Cancer ◽  
Early Stage ◽  
Inflammatory Bowel ◽  
Resected Stage ◽  
Stage Ii Colon Cancer

This chapter covers colorectal cancer, and includes information on epidemiology, risk factors (chronic inflammation/inflammatory bowel disease, radiation, diet and lifestyle, post cholecystectomy, diabetes, obesity and insulin resistance, cigarette smoking, alcohol, ureterocolic anastamosis, and genetic risk factors, screening, and chemoprevention (aspirin, and NSAIDS), the molecular biology and pathology of colorectal cancer, colorectal carcinoma (location, pathologic prognostic markers, and predictive markers), surgical management (colonic cancer and inflammatory bowel disease, hereditary non-polyposis colonic cancer or HNPCC, presenting as an emergency, treatment of polyp or early cancers, liver and lung metastasis, peritoneal disease, results of surgery and treatment for colon cancer, medical management of early stage disease, adjuvant chemotherapy for stage III disease (T1-4, N1-2M0), adjuvant therapy of patients with resected stage II colon cancer, radiotherapy, multidisciplinary care and special groups, the role of allied teams, and surveillance and follow-up.

scholarly journals S0774 Risk Factors for Colorectal Cancer in Inflammatory Bowel Disease: Observations From a Single Center

2020 ◽  
Vol 115 (1) ◽  
pp. S395-S395
Author(s):  
Subash Ghimire ◽  
Amlish Gondal ◽  
Swapna Talluri ◽  
Rasmita Budhathoki ◽  
Sachit Sharma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Single Center ◽  
Inflammatory Bowel

scholarly journals Risk factors for developing high-output ileostomy: a retrospective study

2020 ◽  
Author(s):  
Xiao Jian'an ◽  
Dongxiao Bai ◽  
Lei Li ◽  
Zhiling Shen ◽  
Tianchen Huang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Total Colectomy ◽  
Neoadjuvant Chemoradiotherapy ◽  
Clear Correlation ◽  
Abdominal Infection ◽  
Inflammatory Bowel

Abstract Background: Prophylactic ileostomy and colostomy have been widely used to reduce the risk and complications of anastomotic leakage with high-risk colorectal cancer after operation. However, prophylactic ileostomy itself has some complications, and ileostomy high out-put syndrome is one of them. This study was performed to explore the risk factors of HOS in ileostomy.Methods: A total of 114 patients with HOS were screened out from 494 eligible ileostomy patients in the last five years. The clinical and pathological data were analyzed. The relationship between HOS and clinicopathological data was analyzed. Multivariate analysis was performed by logistic regression.Results: There was no clear correlation between the occurrence of HOS with sex, age, gross typing, histological grade, location of tumors, lymph node metastasis and TNM stage (p > 0.05). Preoperative complications including inflammatory bowel disease, diabetes mellitus and neoadjuvant chemoradiotherapy were risk factors for HOS (p < 0.05). Total colectomy and abdominal infection were risk factors for HOS (p < 0.05) during operation.Conclusion: Inflammatory bowel disease, diabetes mellitus and neoadjuvant radiotherapy and chemotherapy in patients with colorectal cancer are the preoperative risk factors for HOS. Total colectomy and postoperative abdominal infection are the postoperative risk factors for HOS.

Colorectal cancer

2016 ◽  
pp. 444-477
Author(s):  
Alex Boussioutas ◽  
Stephen Fox ◽  
Iris Nagtegaal ◽  
Alexander Heriot ◽  
Jonathan Knowles ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Colon Cancer ◽  
Bowel Disease ◽  
Colonic Cancer ◽  
Early Stage ◽  
Inflammatory Bowel ◽  
Resected Stage ◽  
Stage Ii Colon Cancer

This chapter covers colorectal cancer, and includes information on epidemiology, risk factors (chronic inflammation/inflammatory bowel disease, radiation, diet and lifestyle, post cholecystectomy, diabetes, obesity and insulin resistance, cigarette smoking, alcohol, ureterocolic anastamosis, and genetic risk factors, screening, and chemoprevention (aspirin, and NSAIDS), the molecular biology and pathology of colorectal cancer, colorectal carcinoma (location, pathologic prognostic markers, and predictive markers), surgical management (colonic cancer and inflammatory bowel disease, hereditary non-polyposis colonic cancer or HNPCC, presenting as an emergency, treatment of polyp or early cancers, liver and lung metastasis, peritoneal disease, results of surgery and treatment for colon cancer, medical management of early stage disease, adjuvant chemotherapy for stage III disease (T1-4, N1-2M0), adjuvant therapy of patients with resected stage II colon cancer, radiotherapy, multidisciplinary care and special groups, the role of allied teams, and surveillance and follow-up.

Detection of possible inflammatory bowel disease-related genes using microarray analysis

2001 ◽  
Vol 120 (5) ◽  
pp. A455-A455
Author(s):  
E MANNICK ◽  
M SERRANO ◽  
J BONOMOLO ◽  
M LAU ◽  
J UDALLJR ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Microarray Analysis ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Disease Related Genes
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