Risk factors for developing high-output ileostomy: a retrospective study

Abstract Background: Prophylactic ileostomy and colostomy have been widely used to reduce the risk and complications of anastomotic leakage with high-risk colorectal cancer after operation. However, prophylactic ileostomy itself has some complications, and ileostomy high out-put syndrome is one of them. This study was performed to explore the risk factors of HOS in ileostomy.Methods: A total of 114 patients with HOS were screened out from 494 eligible ileostomy patients in the last five years. The clinical and pathological data were analyzed. The relationship between HOS and clinicopathological data was analyzed. Multivariate analysis was performed by logistic regression.Results: There was no clear correlation between the occurrence of HOS with sex, age, gross typing, histological grade, location of tumors, lymph node metastasis and TNM stage (p > 0.05). Preoperative complications including inflammatory bowel disease, diabetes mellitus and neoadjuvant chemoradiotherapy were risk factors for HOS (p < 0.05). Total colectomy and abdominal infection were risk factors for HOS (p < 0.05) during operation.Conclusion: Inflammatory bowel disease, diabetes mellitus and neoadjuvant radiotherapy and chemotherapy in patients with colorectal cancer are the preoperative risk factors for HOS. Total colectomy and postoperative abdominal infection are the postoperative risk factors for HOS.

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Risk factors for developing high-output ileostomy: a retrospective study

10.21203/rs.3.rs-22014/v2 ◽

2021 ◽

Author(s):

Xiao Jian'an ◽

Dongxiao Bai ◽

Lei Li ◽

Zhiling Shen ◽

Tianchen Huang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Colorectal Cancer ◽

Risk Factors ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Total Colectomy ◽

Neoadjuvant Chemoradiotherapy ◽

Clear Correlation ◽

Abdominal Infection ◽

Inflammatory Bowel

Abstract Background Prophylactic ileostomy and colostomy have been widely used to reduce the risk and complications of anastomotic leakage with high-risk colorectal cancer after operation. However, prophylactic ileostomy itself has some complications, and ileostomy high out-put syndrome is one of them. This study was performed to explore the risk factors of HOS in ileostomy.Methods A total of 114 patients with HOS were screened out from 494 eligible ileostomy patients in the last five years. The clinical and pathological data were analyzed. The relationship between HOS and clinicopathological data was analyzed. Multivariate analysis was performed by logistic regression.Results There was no clear correlation between the occurrence of HOS with sex, age, gross typing, histological grade, location of tumors, lymph node metastasis and TNM stage (p>0.05). Preoperative complications including inflammatory bowel disease, diabetes mellitus and neoadjuvant chemoradiotherapy were risk factors for HOS (p<0.05). Total colectomy and abdominal infection were risk factors for HOS (p<0.05) during operation.Conclusion Inflammatory bowel disease, diabetes mellitus and neoadjuvant radiotherapy and chemotherapy in patients with colorectal cancer are the preoperative risk factors for HOS. Total colectomy and postoperative abdominal infection are the postoperative risk factors for HOS.

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Risk factors for developing high-output ileostomy in CRC patients: a retrospective study

BMC Surgery ◽

10.1186/s12893-021-01288-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Dongxiao Bai ◽

Lei Li ◽

Zhiling Shen ◽

Tianchen Huang ◽

Qingbing Wang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Inflammatory Bowel Disease ◽

Multivariate Analysis ◽

Anastomotic Leakage ◽

Bowel Disease ◽

Total Colectomy ◽

Abdominal Infection ◽

Inflammatory Bowel ◽

High Output

Abstract Background Anastomotic leakage is one of the most serious postoperative complications of rectal cancer. Prophylactic ileostomy has been widely used to reduce the risk and severity of complications of anastomotic leakage. However, prophylactic ileostomy itself has some complications, and ileostomy high output syndrome (HOS) is one of them. This study was performed to explore the risk factors of HOS in ileostomy. Methods A total of 114 patients with HOS were screened out from 494 eligible ileostomy patients in the last 5 years. The relationship between HOS and the clinicopathological data was analyzed using the Chi-square test and Fisher’s exact probability. Multivariate analysis was performed by logistic regression. Results The incidence of HOS was 23.07% in this study. Dehydration was the most common symptom of HOS (37.7%). There was no clear correlation between HOS occurrence with sex, age, gross typing, histological grade, tumor location, lymph node metastasis, and TNM stage (p > 0.05). The incidence of HOS was 14/18 in inflammatory bowel disease patients, 18/28 in diabetes mellitus patients, and 23/72 in neoadjuvant chemoradiotherapy patients, 13/17 in total colectomy and abdominal infection patients. Multivariate analysis showed that they are risk factors for HOS (p < 0.05). Conclusion HOS occurred occasionally but rarely studied and lacks attention. Inflammatory bowel disease, diabetes mellitus, neoadjuvant radiotherapy chemotherapy, total colectomy and abdominal infection are the risk factors for HOS.

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Clostridioides difficile Enteritis in Patients Following Total Colectomy—a Rare but Genuine Clinical Entity

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz409 ◽

2019 ◽

Vol 6 (11) ◽

Author(s):

Robert J Ulrich ◽

Jonathan Bott ◽

Hannah Imlay ◽

Kerri Lopez ◽

Sandro Cinti ◽

...

Keyword(s):

Risk Factors ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Total Colectomy ◽

Severe Disease ◽

Clinical Entity ◽

Acid Suppression ◽

Clostridioides Difficile ◽

Inflammatory Bowel ◽

One Year

Clostridioides difficile enteritis (CDE) after colectomy is an understudied infectious syndrome. We reviewed 20 years of post-colectomy data and found CDE in 44/855 (5.1%) patients, usually within one year of surgery. Risk factors include acid suppression, inflammatory bowel disease, and antibiotics with enteral feeds. Clostridioides difficile enteritis often presents with severe disease requiring hospitalization.

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Risk factors of colorectal cancer in inflammatory bowel disease

Journal of Pediatric Surgery ◽

10.1016/s0022-3468(97)90054-3 ◽

1997 ◽

Vol 32 (5) ◽

pp. 793

Author(s):

Richard R. Ricketts

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Inflammatory Bowel

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S909 Risk Factors for Colorectal Dysplasia and Colorectal Cancer (CRC) Among Patients With Inflammatory Bowel Disease (IBD) Undergoing Surveillance Colonoscopy in a Tertiary Care Center

The American Journal of Gastroenterology ◽

10.14309/01.ajg.0000777168.32638.87 ◽

2021 ◽

Vol 116 (1) ◽

pp. S430-S430

Author(s):

Jaclyn Tuck ◽

Hally Chaffin ◽

Jacqueline Cai ◽

Molly Klanderman ◽

Nan Zhang ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Care Center ◽

Tertiary Care ◽

Tertiary Care Center ◽

Surveillance Colonoscopy ◽

Inflammatory Bowel

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Colorectal cancer

Oxford Textbook of Oncology ◽

10.1093/med/9780199656103.003.0039_update_001 ◽

2016 ◽

pp. 444-477

Author(s):

Alex Boussioutas ◽

Stephen Fox ◽

Iris Nagtegaal ◽

Alexander Heriot ◽

Jonathan Knowles ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Inflammatory Bowel Disease ◽

Colon Cancer ◽

Bowel Disease ◽

Colonic Cancer ◽

Early Stage ◽

Inflammatory Bowel ◽

Resected Stage ◽

Stage Ii Colon Cancer

This chapter covers colorectal cancer, and includes information on epidemiology, risk factors (chronic inflammation/inflammatory bowel disease, radiation, diet and lifestyle, post cholecystectomy, diabetes, obesity and insulin resistance, cigarette smoking, alcohol, ureterocolic anastamosis, and genetic risk factors, screening, and chemoprevention (aspirin, and NSAIDS), the molecular biology and pathology of colorectal cancer, colorectal carcinoma (location, pathologic prognostic markers, and predictive markers), surgical management (colonic cancer and inflammatory bowel disease, hereditary non-polyposis colonic cancer or HNPCC, presenting as an emergency, treatment of polyp or early cancers, liver and lung metastasis, peritoneal disease, results of surgery and treatment for colon cancer, medical management of early stage disease, adjuvant chemotherapy for stage III disease (T1-4, N1-2M0), adjuvant therapy of patients with resected stage II colon cancer, radiotherapy, multidisciplinary care and special groups, the role of allied teams, and surveillance and follow-up.

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