scholarly journals Recent Advances Towards Point-Of-Care Applications of Surface-Enhanced Raman Scattering Sensing

2021 ◽  
Vol 9 ◽  
Author(s):  
Steven Quarin ◽  
Pietro Strobbia
Keyword(s):  
Raman Scattering ◽  
Point Of Care ◽  
Simultaneous Detection ◽  
Surface Enhanced Raman Scattering ◽  
Diagnostic Methods ◽  
Current Standard ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Sers Sensing

The ability to accurately diagnose at the point of care is crucial in many pathologies. However, current standard diagnostic practices can only be performed in specialized health or laboratory settings. To move diagnostic methods from a specialized lab to the point of care many alternate methods have been developed and proposed. Among them surface-enhanced Raman scattering (SERS) sensing offers advantageous features, such as simultaneous detection of multiple biotargets and increased accuracy. Many groups have been working towards the translation of SERS sensing methods from the lab to the point of need. In this mini review, we discuss interesting and recent developments in this effort, focusing on how different sensing mechanism can be used in point-of-care testing applications of SERS.

scholarly journals Duplex Surface Enhanced Raman Scattering-Based Lateral Flow Immunosensor for the Low-Level Detection of Antibiotic Residues in Milk

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5249
Author(s):  
Ruiqi Fan ◽  
Shusheng Tang ◽  
Sunlin Luo ◽  
Hu Liu ◽  
Wanjun Zhang ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Simultaneous Detection ◽  
Surface Enhanced Raman Scattering ◽  
Lateral Flow ◽  
Antibiotic Residues ◽  
Relative Standard ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Analytical Approaches

A duplex surface enhanced Raman scattering (SERS)-based lateral flow immunosensor was established for the simultaneous detection of two common antibiotic residues including tetracycline and penicillin in milk. The newly synthesized Au@Ag nanoparticles were labeled with different Raman molecules including 5,5-dithiobis-2-nitrobenzoic acid (DTNB) or 4-mercaptobenzoic acid (MBA), followed by the conjugation of anti-tetracycline monoclonal antibody or anti-penicillin receptor, forming two kinds of SERS nanoprobes. The two nanoprobes can recognize tetracycline-BSA and ampicillin-BSA, respectively, which facilitates the simultaneous detection of the two types of antibiotics on a single test line. After optimization, detection limits of tetracycline and penicillin as low as 0.015 ng/mL and 0.010 ng/mL, respectively, were achieved. These values were far below those of most of other documented bio-analytical approaches. Moreover, the spiking test demonstrates an excellent assay accuracy with recoveries of 88.8% to 111.3%, and satisfactory assay precision with relative standard deviation below 16%. Consequently, the results demonstrate that the SERS-based lateral flow immunosensor developed in this study has the advantages of excellent assay sensitivity and remarkable multiplexing capability, thus it will have great application potential in food safety monitoring.

scholarly journals Surface-Enhanced Raman Scattering-Based Lateral-Flow Immunoassay

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2228
Author(s):  
Boris Khlebtsov ◽  
Nikolai Khlebtsov
Keyword(s):  
Raman Scattering ◽  
Point Of Care ◽  
Surface Enhanced Raman Scattering ◽  
Environmental Safety ◽  
Lateral Flow ◽  
Wide Range ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Low Sensitivity

Lateral flow immunoassays (LFIAs) have been developed and used in a wide range of applications, in point-of-care disease diagnoses, environmental safety, and food control. However, in its classical version, it has low sensitivity and can only perform semiquantitative detection, based on colorimetric signals. Over the past decade, surface-enhanced Raman scattering (SERS) tags have been developed in order to decrease the detection limit and enable the quantitative analysis of analytes. Of note, these tags needed new readout systems and signal processing algorithms, while the LFIA design remained unchanged. This review highlights SERS strategies of signal enhancement for LFIAs. The types of labels used, the possible gain in sensitivity from their use, methods of reading and processing the signal, and the prospects for use are discussed.

Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review

2022 ◽  
Author(s):  
Yingjie Hang ◽  
Jennifer Boryczka ◽  
Nianqiang Wu
Keyword(s):  
Raman Scattering ◽  
Visible Light ◽  
Near Infrared ◽  
Point Of Care ◽  
Surface Enhanced Raman Scattering ◽  
Near Infrared Fluorescence ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Bio Imaging ◽  
Enhanced Raman Scattering

This article reviews the principles, design and applications of visible-light and near-infrared fluorescence and surface-enhanced Raman scattering in point-of-care testing and bio-imaging.

Simply controllable growth of single crystal plasmonic Au–Ag nano-spines with anisotropic multiple sites for highly sensitive and uniform surface-enhanced Raman scattering sensing

RSC Advances ◽  
2016 ◽  
Vol 6 (70) ◽  
pp. 66056-66065 ◽  
Author(s):  
Dongzhen Chen ◽  
Zhongxiao Song ◽  
Feng Chen ◽  
Jian Huang ◽  
Jing Wei ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Single Crystal ◽  
Hot Spots ◽  
Surface Enhanced Raman Scattering ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Controllable Growth ◽  
Enhanced Raman Scattering ◽  
Sers Sensing

Simply synthesizing Au core@Au–Ag alloy spine nanostructures with a highly tunable LSPR band and dense “hot spots” for SERS sensing.

Graphene-based nanoplatforms for surface-enhanced Raman scattering sensing

The Analyst ◽  
2018 ◽  
Vol 143 (21) ◽  
pp. 5074-5089 ◽  
Author(s):  
Zhuqing Wang ◽  
Shasha Wu ◽  
Lucio Colombi Ciacchi ◽  
Gang Wei
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Sensing Applications ◽  
Recent Advances ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Sers Sensing

We demonstrate recent advances in the fabrication and SERS sensing applications of graphene-based nanoplatforms.

Simultaneous detection of clenbuterol and ractopamine based on multiplexed competitive surface enhanced Raman scattering (SERS) immunoassay

2017 ◽  
Vol 41 (18) ◽  
pp. 10407-10414 ◽  
Author(s):  
Meng Yu ◽  
Yongjun Hu ◽  
Jianzhi Liu
Keyword(s):  
Raman Scattering ◽  
Simultaneous Detection ◽  
Surface Enhanced Raman Scattering ◽  
Multiplexed Detection ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

In this work, we demonstrate a competitive surface-enhanced Raman scattering (SERS) immunoassay for multiplexed detection of clenbuterol and ractopamine.

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