Association Between Thyroid Hormones, Thyroid Antibodies, and Cardiometabolic Factors in Non-Obese Individuals With Normal Thyroid Function

BackgroundThyroid dysfunction is relatively common in patients with schizophrenia.This study seeks to determine the prevalence and pattern of thyroid dysfunction and thyroid antibodies presence in a group of adult psychiatric inpatients with chronic schizophrenia.MethodsThyroid function tests and thyroid antibodies measurement were performed on 88 patients hospitalized in Psichiatric Clinic of UHC “Mother Teresa” from december 2006 to december 2007.55 of them (62,5%) were females and 33 of them (37,5%) males. A median age of 43 years (range16 to 70 years) and a median duration of hospitalization of 10 years (range 1 to 30 years) was assessed.ResultsTAb were found in 22 patients (25%), of which 18 females and 4 males. 16% of them resulted with positive anticorps for Hashimoto Thyroiditis; 9% for Graves‘disease.According to thyroid function tests70% had normal test, 8% had elevated TSH: 3% of them with low thyroid hormones and 5% with normal thyroid hormones. 20% of cases had low TSH: 5% of them with high level of thyroid hormones, 15% with normal thyroid hormones. Hypothyroidism was more frequent in elderly patients ( > 60 years old), and in those treated with Risperidone. Most of cases (73%) with thyroid disorders resulted from endemic geographic areas. 37% of them mentioned familial history for thyroid pathology, and 23% for diabetes mellitus type 1.ConclusionThyroid abnormalities are common in patients with chronic schizophrenia.This fact call for caution in the use and interpretation of thyroid function tests in these patients.

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Inter relationship between thyroid hormones and selenium in individuals with normal thyroid function

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2011.08.256 ◽

2011 ◽

Vol 44 (13) ◽

pp. S107-S108

Author(s):

Rahim Rostami ◽

Asghar Beiranvand ◽

Jaffar Nourooz-zadeh

Keyword(s):

Thyroid Hormones ◽

Thyroid Function ◽

Normal Thyroid ◽

Normal Thyroid Function

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Weight Loss Through Gastric Banding: Effects on TSH and Thyroid Hormones in Obese Subjects With Normal Thyroid Function

Obesity ◽

10.1038/oby.2009.320 ◽

2010 ◽

Vol 18 (4) ◽

pp. 854-857 ◽

Cited By ~ 38

Author(s):

Chiara Dall'Asta ◽

Michele Paganelli ◽

Alberto Morabito ◽

Paola Vedani ◽

Michelangela Barbieri ◽

...

Keyword(s):

Weight Loss ◽

Thyroid Hormones ◽

Gastric Banding ◽

Thyroid Function ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Obese Subjects

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Relationship between thyroid hormones and metabolic syndrome in a normal thyroid function population in Western China

Chinese Medical Journal ◽

10.1097/cm9.0000000000001553 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Sheng-Ru Liang ◽

Jing Cai ◽

Yang Yang ◽

Lei Zhang ◽

Peter Taylor ◽

...

Keyword(s):

Metabolic Syndrome ◽

Thyroid Hormones ◽

Thyroid Function ◽

Western China ◽

Normal Thyroid ◽

Normal Thyroid Function

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High Prevalence of Anti Thyroid Antibodies in an Albanian Cohort of Patients

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.1693 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A830-A831

Author(s):

Dorina Minxuri ◽

Anila Mitre ◽

Silva Bino ◽

Ina Toska ◽

Ina Mulla

Keyword(s):

Thyroid Function ◽

Subclinical Hypothyroidism ◽

Thyroid Dysfunction ◽

Thyroid Disorders ◽

Thyroid Antibodies ◽

Positive Group ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Significant Difference ◽

High Prevalence

Abstract Introduction: Albania is classified as iodine deficient region and endemic goiter in this country has been a concern for public health. A salt iodization program has been implemented in Albania since 2008. Most of regions still remain with a mild or moderate iodine deficiency there are no studies on prevalence of thyroid autoimmune disorders. The purpose of this study was to assess thyroid function and the presence of thyroid antibodies in subjects that were not previously diagnosed or treated for thyroid disorders. Methods: This is a cross-sectional study performed in a cohort of patients in Albania during a 2 year period (january 2018-january 2020). We assessed the prevalence of thyroid function disorders and presence of thyroid antibodies in 5047 subjects (81% females and 19% males). Individuals previously diagnosed or treated for thyroid disease were excluded from the study. TSH, Free T4, total T3, Anti TPO(thyroid peroxidase) and anti TG (thyroglobulin) were measured with electrochemiluminescence method with Cobas 6000 Roche Diagnostics. We calculated the frequency of thyroid antibodies and the abnormal thyroid function. Statistical analysis was performed to see if there was a difference between individuals with positive antibodies and those negative for antibodies. Results: 91 % (4596) of subjects resulted euthyroid. We found a low prevalence of overt thyroid dysfunction (hyperthyroidism 0.48% and hypothyroidism 1.69%). The rates of subclinical hypothyroidism and hyperthyroidism were 5.5% and 1.4% respectively. The prevalence of positive thyroid antibodies, at least one of them was 28% in females and 14% in males (2:1 ratio). 97.3 % of subjects who testet negative for antibodies had normal thyroid function compared to 73.5% in antibodies positive group. There was a significant difference for subclinical hypothyroidism and other thyroid disorders between antibodies positive group and antibodies negative group (p value <0.0000119% of individuals(from 5047 examined) had normal thyroid function and resulted positive for anti TPO or anti TG. Conclusions: Undiagnosed biochemical thyroid dysfunctions were common in subjects living in a mild to moderate iodine-deficient area especially subclinical hypothyroidism. TSH level correlated well with the presence of antibodies resulting in significant difference in thyroid function between 2 groups. We found a high prevalence (19%) of thyroid antibodies in euthyroid subjects. TPO antibodies in euthyroid subjects can be used to identify subjects with increased risk for hypothyroidism such as women who are pregnant (to predict first trimester or postpartum thyroid dysfunction), patients with other autoimmune diseases, subjects on drugs like amiodarone or relatives of patients with autoimmune thyroid diseases.

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Radioiodine treatment of feline hyperthyroidism in Germany

Nuklearmedizin ◽

10.1055/s-0038-1625296 ◽

2002 ◽

Vol 41 (06) ◽

pp. 245-251 ◽

Cited By ~ 3

Author(s):

M. Knietsch ◽

T. Spillmann ◽

E.-G. Grünbaum ◽

R. Bauer ◽

M. Puille

Keyword(s):

Radiation Exposure ◽

Radiation Protection ◽

Thyroid Function ◽

Radioiodine Therapy ◽

Whole Body ◽

Radioiodine Treatment ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Body Activity ◽

Thyroid Uptake

SummaryAim: Establishment of radioiodine treatment of feline hyperthyroidism in veterinary routine in accordance with German radiation protection regulations. Patients and methods: 35 cats with proven hyperthyroidism were treated with 131I in a special ward. Thyroid uptake and effective halflife were determined using gammacamera dosimetry. Patients were released when measured whole body activity was below the limit defined in the German “Strahlenschutzverordnung”. Results: 17/20 cats treated with 150 MBq radioiodine and 15/15 cats treated with 250 MBq had normal thyroid function after therapy, normal values for FT3 and FT4 were reached after two and normal TSH levels after three weeks. In 14 cats normal thyroid function was confirmed by controls 3-6 months later. Thyroidal iodine uptake was 24 ± 10%, effective halflife 2.5 ± 0.7 days. Whole body activity <1 MBq was reached 13 ± 4 days after application of 131I. Radiation exposure of cat owners was estimated as 1.97 Sv/MBq for adults. Conclusion: Radioiodine therapy of feline hyper-thyroidism is highly effective and safe. It can easily be performed in accordance with German radiation protection regulations, although this requires hospitalisation for approximately two weeks. Practical considerations on radiation exposure of cat owners do not justify this long interval. Regulations for the veterinary use of radioactive substances similar to existing regulations for medical use in humans are higly desirable.

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Thyroid dysfunction is associated with the loss of hepatitis B surface antigen in patients with chronic hepatitis B undergoing treatment with α-interferon

Journal of International Medical Research ◽

10.1177/03000605211025139 ◽

2021 ◽

Vol 49 (6) ◽

pp. 030006052110251

Author(s):

Wenfan Luo ◽

Shuai Wu ◽

Hongjie Chen ◽

Yin Wu ◽

Jie Peng

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

Thyroid Function ◽

Thyroid Dysfunction ◽

Hepatitis B Surface Antigen ◽

Hbv Dna ◽

Interferon Treatment ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Hbsag Loss

Objective To investigate the influence of thyroid dysfunction on the antiviral efficacy of α-interferon in adult patients with chronic hepatitis B (CHB). Methods We performed a retrospective study of 342 patients with CHB who underwent interferon treatment for >12 weeks. Patients with thyroid dysfunction before or during treatment were defined as the thyroid dysfunction group (n = 141) and those with normal thyroid function were defined as the normal thyroid function group (n = 201). The prevalences of hepatitis B virus (HBV) DNA undetectability, low hepatitis B surface antigen (HBsAg) titre (<250 IU/mL), HBsAg loss, and hepatitis B envelope antigen loss were compared. Results During interferon treatment, 69 of 270 (25.6%) participants with normal thyroid function at baseline developed thyroid dysfunction, whereas 11 of 72 (15.3%) with thyroid dysfunction at baseline regained normal thyroid function. The thyroid dysfunction group had significantly higher prevalences of low HBsAg titre (29.8% vs. 18.9%) and HBV DNA undetectability (66.0% vs. 40.3%). Multivariate logistic regression analysis showed that thyroid dysfunction was associated with HBsAg loss (odds ratio 4.945, 95% confidence interval 1.325–18.462). Conclusions These results suggest that thyroid dysfunction is not an absolute contraindication, but is associated with HBsAg loss, in patients with CHB undergoing α-interferon treatment.

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Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation

BMC Endocrine Disorders ◽

10.1186/s12902-021-00715-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Tuo Deng ◽

Wenwen Zhang ◽

Yanling Zhang ◽

Mengqi Zhang ◽

Zhikun Huan ◽

...

Keyword(s):

Thyroid Function ◽

Thyroid Stimulating Hormone ◽

Mrna Levels ◽

Dependent Manner ◽

Osteoblast Proliferation ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Gene And Protein Expression ◽

Proliferation And Differentiation ◽

Stimulating Hormone

Abstract Background As the incidence of secretory osteoporosis has increased, bone loss, osteoporosis and their relationships with thyroid-stimulating hormone (TSH) have received increased attention. In this study, the role of TSH in bone metabolism and its possible underlying mechanisms were investigated. Methods We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and TSH and the bone mineral density (BMD) levels of 114 men with normal thyroid function. In addition, osteoblasts from rat calvarial samples were treated with different doses of TSH for different lengths of time. The related gene and protein expression levels were investigated. Results A comparison of the BMD between the high-level and low-level serum TSH groups showed that the TSH serum concentration was positively correlated with BMD. TSH at concentrations of 10 mU/mL and 100 mU/mL significantly increased the mRNA levels of ALP, COI1 and Runx2 compared with those of the control (P < 0.05, P < 0.01). Bone morphogenetic protein (BMP)2 activity was enhanced with both increased TSH concentration and increased time. The protein levels of Runx2 and osterix were increased in a dose-dependent manner. Conclusions The circulating concentrations of TSH and BMD were positively correlated with normal thyroid function in males. TSH promoted osteoblast proliferation and differentiation in rat primary osteoblasts.

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Subtotal thyroidectomy: Treatment of mild or moderate congestive failure in valvular heart disease and normal thyroid function

American Heart Journal ◽

10.1016/0002-8703(48)90484-0 ◽

1948 ◽

Vol 35 (5) ◽

pp. 833

Author(s):

Hecht

Keyword(s):

Heart Disease ◽

Thyroid Function ◽

Valvular Heart Disease ◽

Subtotal Thyroidectomy ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Congestive Failure

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Levothyroxine Augmentation in Clozapine Resistant Schizophrenia: A Case Report and Review

Case Reports in Psychiatry ◽

10.1155/2015/678040 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4

Author(s):

Ruohollah Seddigh ◽

Somayeh Azarnik ◽

Amir-Abbas Keshavarz-Akhlaghi

Keyword(s):

Clinical Trials ◽

Treatment Outcome ◽

Case Report ◽

Thyroid Hormones ◽

Antipsychotic Drugs ◽

Paranoid Schizophrenia ◽

Controlled Clinical Trials ◽

Normal Thyroid ◽

Normal Thyroid Function ◽

Thyroid Abnormalities

There are many reports that show different thyroid abnormalities in schizophrenia without clear establishment of their role in etiology and treatment outcome of schizophrenia. Among these reports, there are only a few that consider a role for thyroid hormones as augmenting agents in the treatment with antipsychotic drugs. This case report outlines symptom subsidence of a patient with clozapine refractory paranoid schizophrenia and normal thyroid function who added levothyroxine to clozapine and found that symptoms of psychosis returned once levothyroxine was discontinued. Although this observation needs to be confirmed in controlled clinical trials, we aimed to discuss possible hypothesized mechanisms underlying this observation.

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