scholarly journals Critical Role of Tumor Necrosis Factor Signaling in Mesenchymal Stem Cell-Based Therapy for Autoimmune and Inflammatory Diseases

2018 ◽  
Vol 9 ◽  
Author(s):  
Li Yan ◽  
Dejin Zheng ◽  
Ren-He Xu
2016 ◽  
Vol Volume 11 ◽  
pp. 1705-1712 ◽  
Author(s):  
Masaki Fujita ◽  
Ouchi Hiroshi ◽  
Satoshi Ikemage ◽  
Eiji Harada ◽  
Takemasa Matsumoto ◽  
...  

2017 ◽  
Vol 21 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Masae Ritsu ◽  
Kazuyoshi Kawakami ◽  
Emi Kanno ◽  
Hiromasa Tanno ◽  
Keiko Ishii ◽  
...  

1999 ◽  
Vol 190 (11) ◽  
pp. 1697-1710 ◽  
Author(s):  
Fabienne Mackay ◽  
Stephen A. Woodcock ◽  
Pornsri Lawton ◽  
Christine Ambrose ◽  
Manfred Baetscher ◽  
...  

The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases. BAFF, a new member of the TNF family, binds to B cells and costimulates their growth in vitro. Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys. This phenotype is reminiscent of certain human autoimmune disorders and suggests that dysregulation of BAFF expression may be a critical element in the chain of events leading to autoimmunity.


2009 ◽  
Vol 87 (3) ◽  
pp. 812-819 ◽  
Author(s):  
Courtney N. Zeller ◽  
Yue Wang ◽  
Troy A. Markel ◽  
Brent Weil ◽  
Aaron Abarbanell ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document