scholarly journals Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Katrien Van der Borght ◽  
Charlotte L. Scott ◽  
Liesbet Martens ◽  
Dorine Sichien ◽  
Gert Van Isterdael ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Antigen Presentation ◽  
Self Antigen ◽  
Conventional Type

scholarly journals IRF4 Expression Is Required for the Immunoregulatory Activity of Conventional Type 2 Dendritic Cells in Settings of Chronic Bacterial Infection and Cancer

2020 ◽  
Vol 205 (7) ◽  
pp. 1933-1943
Author(s):  
Xiaozhou Zhang ◽  
Mariela Artola-Boran ◽  
Angela Fallegger ◽  
Isabelle C. Arnold ◽  
Achim Weber ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Bacterial Infection ◽  
Conventional Type

scholarly journals Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses

2019 ◽  
Author(s):  
Jihyung Lee ◽  
Junyan Zhang ◽  
Young-Jun Chung ◽  
Jun Hwan Kim ◽  
Chae Min Kook ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Dendritic Cells ◽  
Molecular Basis ◽  
Camp Signaling ◽  
Biological Processes ◽  
The Novel ◽  
Microbial Product ◽  
Conventional Type ◽  
Recognition Receptor

AbstractCyclic AMP (cAMP) is involved in multiple biological processes. However, little is known about its role in shaping immunity. Here we show that cAMP-PKA-CREB signaling (a pattern recognition receptor [PRR]-independent) regulates conventional type-2 Dendritic Cells (cDC2s), but not cDC1s and reprograms their Th17-inducing properties via repression of IRF4 and KLF4, transcription factors (TFs) for Th2 induction. Genetic loss of IRF4 phenocopies the effects of cAMP signaling on Th17-induction, indicating that the cAMP effect is secondary to repression of IRF4. Moreover, signaling in cDC2s by a PRR-dependent microbial product, curdlan, represses IRF4 and KLF4, resulting in a pro-Th17 phenotype. These results define a novel signaling pathway by which cDC2s display plasticity and provide a new molecular basis for the novel cDC2 and cDC17 classification. In addition, the data reveal that cAMP signaling can alter DCs function and fate by repressing IRF4 and KLF4, a pathway that can be harnessed for immuno-regulation.

scholarly journals Self-Antigen Presentation by Dendritic Cells in Autoimmunity

2014 ◽  
Vol 5 ◽  
Author(s):  
Ann-Katrin Hopp ◽  
Anne Rupp ◽  
Veronika Lukacs-Kornek
Keyword(s):  
Dendritic Cells ◽  
Antigen Presentation ◽  
Self Antigen

scholarly journals A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

Cell Reports ◽  
2017 ◽  
Vol 21 (5) ◽  
pp. 1203-1214 ◽  
Author(s):  
Jianpeng Sheng ◽  
Qi Chen ◽  
Irene Soncin ◽  
See Liang Ng ◽  
Klaus Karjalainen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Discrete Subset ◽  
Conventional Type

scholarly journals Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin

Immunology ◽  
2009 ◽  
Vol 128 (1pt2) ◽  
pp. e237-e249 ◽  
Author(s):  
Meixiang Yang ◽  
Chunhong Ma ◽  
Shuxun Liu ◽  
Jintang Sun ◽  
Qianqian Shao ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Tumour Cell ◽  
T Helper ◽  
Helper Type

scholarly journals Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Jihyung Lee ◽  
Junyan Zhang ◽  
Young-Jun Chung ◽  
Jun Hwan Kim ◽  
Chae Min Kook ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Biological Processes ◽  
Microbial Product ◽  
Independent Mechanism ◽  
Conventional Type ◽  
Recognition Receptor

Cyclic AMP (cAMP) is involved in many biological processes but little is known regarding its role in shaping immunity. Here we show that cAMP-PKA-CREB signaling (a pattern recognition receptor [PRR]-independent mechanism) regulates conventional type-2 Dendritic Cells (cDC2s) in mice and reprograms their Th17-inducing properties via repression of IRF4 and KLF4, transcription factors essential for cDC2-mediated Th2 induction. In mice, genetic loss of IRF4 phenocopies the effects of cAMP on Th17 induction and restoration of IRF4 prevents the cAMP effect. Moreover, curdlan, a PRR-dependent microbial product, activates CREB and represses IRF4 and KLF4, resulting in a pro-Th17 phenotype of cDC2s. These in vitro and in vivo results define a novel signaling pathway by which cDC2s display plasticity and provide a new molecular basis for the classification of novel cDC2 and cDC17 subsets. The findings also reveal that repressing IRF4 and KLF4 pathway can be harnessed for immuno-regulation.

scholarly journals Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventional Type 1 Dendritic Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 158 ◽  
Author(s):  
João Calmeiro ◽  
Mylène A. Carrascal ◽  
Adriana Ramos Tavares ◽  
Daniel Alexandre Ferreira ◽  
Célia Gomes ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Cancer Immunotherapy ◽  
Natural Killer ◽  
Ex Vivo ◽  
Great Effort ◽  
Tumor Vaccines ◽  
Conventional Type

Throughout the last decades, dendritic cell (DC)-based anti-tumor vaccines have proven to be a safe therapeutic approach, although with inconsistent clinical results. The functional limitations of ex vivo monocyte-derived dendritic cells (MoDCs) commonly used in these therapies are one of the pointed explanations for their lack of robustness. Therefore, a great effort has been made to identify DC subsets with superior features for the establishment of effective anti-tumor responses and to apply them in therapeutic approaches. Among characterized human DC subpopulations, conventional type 1 DCs (cDC1) have emerged as a highly desirable tool for empowering anti-tumor immunity. This DC subset excels in its capacity to prime antigen-specific cytotoxic T cells and to activate natural killer (NK) and natural killer T (NKT) cells, which are critical factors for an effective anti-tumor immune response. Here, we sought to revise the immunobiology of cDC1 from their ontogeny to their development, regulation and heterogeneity. We also address the role of this functionally thrilling DC subset in anti-tumor immune responses and the most recent efforts to apply it in cancer immunotherapy.

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