scholarly journals Psychological Stresses in Children Trigger Cytokine- and Kynurenine Metabolite-Mediated Abdominal Pain and Proinflammatory Changes

2021 ◽  
Vol 12 ◽  
Author(s):  
Kyaimon Myint ◽  
Kelly Jacobs ◽  
Aye-Mu Myint ◽  
Sau Kuen Lam ◽  
Yvonne Ai-Lian Lim ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
High Performance ◽  
Medically Unexplained Symptoms ◽  
Recurrent Abdominal Pain ◽  
Kynurenine Pathway ◽  
Parasitic Infections ◽  
Inflammatory State ◽  
Medically Unexplained ◽  
Tryptophan Catabolites ◽  
Factor Α

Recurrent abdominal pain (RAP) is a common medically unexplained symptom among children worldwide. However, the biological mechanisms behind the development of functional and behavioral symptoms and changes in blood markers have not been well explored. This study aimed to assess changes in the concentrations of inflammatory markers, including cytokines and tryptophan catabolites, in the serum of children with RAP compared to those with subclinical infections. Children with RAP but without organic diseases were included, and those with asymptomatic intestinal parasitic infections were used as a subclinical infection cohort. Blood samples were collected and used to measure the cytokine profile using Multiplex Immunoassay and tryptophan catabolites using high performance liquid chromatography. Children with RAP showed significantly higher concentrations of serum tumor necrotic factor-α, p<0.05, but lower concentrations of IL-10, p<0.001, IL-6, p<0.001 and brain-derived neurotrophic factors (BDNF) p<0.01. In addition, a significant increase in the metabolite of the kynurenine pathway, 3-hydroxyanthranilic acid (3-HAA) p<0.01, a significant decrease in the concentrations of anthranilic acid (AA) p<0.001, together with an increased ratio of serum 3-HAA to AA (3-HAA/AA) p<0.001, was found in this cohort. These findings indicate the significant activation of the immune system and presence of inflammation in children with RAP than those with subclinical parasitic infections. Moreover, children with RAP tested with the Strengths and Difficulties Questionnaire (SDQ), displayed high psychological problems though these SDQ scores were not statistically associated with measured cytokines and kynurenine metabolites. We however could hypothesize that the pro-inflammatory state together with concomitant low concentrations of BDNF in those children with RAP could play a role in psychological stress and experiencing medically unexplained symptoms.

scholarly journals Recurent Abdominal Pain and Intestinal Parasitosis. Our Results in a one Year Study.

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Ferizat Dika – Haxhirexha ◽  
Violeta Shehu ◽  
Ledia Qatipi ◽  
Aulona Haxhirexha ◽  
Aferdita Ademi
Keyword(s):  
Abdominal Pain ◽  
Intestinal Parasites ◽  
Recurrent Abdominal Pain ◽  
Parasitic Infections ◽  
Lower Socioeconomic ◽  
Intestinal Parasitosis ◽  
Bowel Diseases ◽  
Stool Samples ◽  
One Year ◽  
Organic Disorder

Background: Abdominal pain in children is the most common problem with which the pediatricians faces in their practice. Recurrent abdominal pain is defined as " the presence of at least three episodes of abdominal pain over a period longer than three months and severe enough to affect the activities of the children". Even though it is considered that functional bowel diseases are the most common cause of recurrent abdominal pain several studies have recognized that numerous organic disorder such as intestinal parasitic infections may lead to abdominal pain. Aim: The aim of this study is to observe the prevalence and the type of intestinal parasites in a representative sample of children living in the municipalities of Tetova and Dibra. Materials and methods: Our study was done in a period between January 2018-2019 in the municipalities of Tetova and Dibra. Totally 470 children examined due to recurrent abdominal pain from the pediatrician was subject of this study.Collected stool samples was checked for the presence of intestinal parasites in microbiological laboratories in Tetova and Dibra. Results: 470 children were included in our study. 248 of them were girls and 222 boys with a median age of 8.2 years. 67 of the children were positive (14.25 %) for intestinal parasites.  Conclusions: Our study reveals that intestinal parasites were frequent among children in our country. The incidence of intestinal parasitosis is higher among the children who come from families with lower socioeconomic status compared to children who come from families with good conditions. The same situation is related to education, respectively children of educated parents are least vulnerable to intestinal parasitosis.

scholarly journals Recurrent abdominal pain in children and adolescents: a hospital based study

2017 ◽  
Vol 4 (3) ◽  
pp. 726
Author(s):  
Arindam Bandyopadhyay ◽  
Pijush Kanti Mondal
Keyword(s):  
Abdominal Pain ◽  
Family History ◽  
Physical Examination ◽  
Children And Adolescents ◽  
Patient Population ◽  
Recurrent Abdominal Pain ◽  
Parasitic Infections ◽  
Age Group ◽  
Male Predominance ◽  
The Common

Background: Recurrent abdominal pain (RAP) is very common in children of age group below 15 years. It affects about 10-20% of school going children. It is comprised of both organic and nonorganic causes and is therefore very challenging in diagnosing and treating the disorder. Hence this study was aimed to determine causes of RAP in the patients involved in the study.Methods: This was a hospital based study and includes 100 patients of age group of 2 to 15 years attending the pediatric and medicine OPD of College of medicine and Sagore Dutta Hospital, from May 2014 to April 2015. These children were subjected to thorough physical examination, systemic and clinical examinations, lab investigations and finally categorized the causes for RAP either as organic or nonorganic.Results: Out of 100 patients of RAP, male predominance (67%) was seen and forty-four (44%) of the patient population belonged to age group of 4 to 6 years. Organic RAP was found in 88% of patients and RAP due to non-organic causes was found in 12% of patients.Conclusions: Organic cause predominantly parasitic infections were found to be the common etiological factor for RAP in most of the children. Family history associated RAP was dominated in nonorganic etiology. 

Internal Medicine Physicians and Social Media: Knowledge, Skills, and Attitudes (Preprint)

2020 ◽  
Author(s):  
Mohaammed Nadir Bhuiyan ◽  
Jose R Medina-Inojosa ◽  
Ivana Croghan ◽  
Jasmine R Marcelin ◽  
Karthik Ghosh ◽  
...  
Keyword(s):  
Social Media ◽  
Medical Education ◽  
Healthcare Delivery ◽  
Medically Unexplained Symptoms ◽  
Audience Response ◽  
Cross Sectional ◽  
Physician Awareness ◽  
Medically Unexplained ◽  
Use Of Social Media ◽  
Continued Medical Education

UNSTRUCTURED This research study was designed to understand physician awareness and engagement with social media (sometimes referred to as #SoMe) within the digital landscape of healthcare delivery. An audience-response survey focused on social media “Social media in Healthcare: Physician Survey”, was administered during the “A Systematic Approach to Medically Unexplained Symptoms” continuing medical education conference. The Conference took place between August 22, 2019 and August 24, 2019. Data was collected on August 23, 2019. A range of 103 (59.5%) to 112 (64.7%) of the total 173 attendees participated in this cross-sectional audience-response survey, depending on the questions answered. Most responders were between the ages of 35 and 65 years (79.6%) and female (60.2%). A majority of responders were aware of social media terminology (88.7%), and many had used it personally (46.7%), but only 12% knew how to use social media to search medical topics, 18% used it to network professionally and most (68.9%) had a distrust of social media when it came to the protection of their privacy or their patients’ privacy. Overall, about 29.6% indicated an interest in future continued medical education focused on social media (and 27.4% were neutral). Awareness of social media’s role in healthcare has increased among physicians in practice, however their participation and knowledge of opportunities remains limited. Distance from academic institutions and concerns about privacy play the largest roles in the aversion towards professional use of social media.

A RARE CAUSE OF SEVERE RECURRENT ABDOMINAL PAIN

2013 ◽  
Vol 68 (1) ◽  
pp. 68-70
Author(s):  
C Isen ◽  
C Ivens ◽  
SFJ Callens ◽  
J Meeuwissen ◽  
A Vonck ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Recurrent Abdominal Pain
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