scholarly journals Nonclassical Monocytes Are Prone to Migrate Into Tumor in Diffuse Large B-Cell Lymphoma

2021 ◽  
Vol 12 ◽  
Author(s):  
Simon Le Gallou ◽  
Faustine Lhomme ◽  
Jonathan M. Irish ◽  
Anna Mingam ◽  
Celine Pangault ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
B Cell ◽  
Peripheral Blood ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Mass Cytometry ◽  
Absolute Count ◽  
Large B Cell Lymphoma ◽  
Inflammatory Phenotype ◽  
Large B Cell

Absolute count of circulating monocytes has been proposed as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, monocyte nomenclature includes various subsets with pro-, anti-inflammatory, or suppressive functions, and their clinical relevance in DLBCL has been poorly explored. Herein, we broadly assessed circulating monocyte heterogeneity in 91 DLBCL patients. Classical- (cMO, CD14pos CD16neg) and intermediate- (iMO, CD14pos CD16pos) monocytes accumulated in DLBCL peripheral blood and exhibited an inflammatory phenotype. On the opposite, nonclassical monocytes (ncMOSlanpos, CD14low CD16pos Slanneg and ncMOSlanneg, CD14low CD16pos, Slanneg) were decreased in peripheral blood. Tumor-conditioned monocytes presented similarities with ncMO phenotype from DLBCL and were prone to migrate in response to CCL5 and CXCL12, and presented similarities with DLBCL-infiltrated myeloid cells, as defined by mass cytometry. Finally, we demonstrated the adverse value of an accumulation of nonclassical monocytes in 2 independent cohorts of DLBCL.

Peripheral blood lymphocyte/monocyte ratio as a useful prognostic factor in dogs with diffuse large B-cell lymphoma receiving chemoimmunotherapy

2015 ◽  
Vol 206 (2) ◽  
pp. 226-230 ◽  
Author(s):  
Laura Marconato ◽  
Valeria Martini ◽  
Damiano Stefanello ◽  
Pierangelo Moretti ◽  
Roberta Ferrari ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
B Cell ◽  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Nonclassical monocytes are prone to migrate into tumor in diffuse large B-cell lymphoma

2021 ◽  
Author(s):  
Simon Le Gallou ◽  
Faustine Lhomme ◽  
Jonathan M. Irish ◽  
Anna Mingam ◽  
Celine Pangault ◽  
...  
Keyword(s):  
B Cell ◽  
Peripheral Blood ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
List Type ◽  
High Count ◽  
Large B Cell Lymphoma ◽  
Key Points ◽  
Inflammatory Phenotype ◽  
Large B Cell

AbstractAbsolute count of circulating monocytes has been proposed as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, monocyte nomenclature includes various subsets with pro-, anti-inflammatory, or suppressive functions, and their clinical relevance in DLBCL has been poorly explored. Herein, we broadly assessed circulating monocyte heterogeneity in 91 DLBCL patients. Classical- (cMO, CD14pos CD16neg) and intermediate- (iMO, CD14pos CD16pos) monocytes accumulated in DLBCL peripheral blood and exhibited an inflammatory phenotype. On the opposite, nonclassical monocytes (ncMO, CD14low CD16pos) were decreased in peripheral blood. Tumor-conditioned monocytes presented similarities with ncMO phenotype from DLBCL and were prone to migrate in response to CCL3, CCL5, and CXCL12, and presented similarities with DLBCL-infiltrated myeloid cells, as defined by mass cytometry. Finally, we demonstrated the adverse value of an accumulation of nonclassical monocytes in 2 independent cohorts of DLBCL.Key pointsNonclassical monocytes are prone to migrate to DLBCL tumorHigh count of circulating nonclassical monocytes is an independent adverse event in DLBCL

Peripheral blood absolute lymphocyte/monocyte ratio as a useful prognostic factor in diffuse large B-cell lymphoma in the rituximab era

2013 ◽  
Vol 92 (3) ◽  
pp. 204-210 ◽  
Author(s):  
Reina Watanabe ◽  
Naoto Tomita ◽  
Megumi Itabashi ◽  
Daisuke Ishibashi ◽  
Eri Yamamoto ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
B Cell ◽  
Peripheral Blood ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Geriatric nutritional risk index as a prognostic factor in patients with diffuse large B cell lymphoma

2018 ◽  
Vol 97 (6) ◽  
pp. 999-1007 ◽  
Author(s):  
Yusuke Kanemasa ◽  
Tatsu Shimoyama ◽  
Yuki Sasaki ◽  
Tsunekazu Hishima ◽  
Yasushi Omuro
Keyword(s):  
Prognostic Factor ◽  
B Cell ◽  
Cell Lymphoma ◽  
Risk Index ◽  
B Cell Lymphoma ◽  
Nutritional Risk ◽  
Geriatric Nutritional Risk Index ◽  
Large B Cell Lymphoma ◽  
Nutritional Risk Index ◽  
Large B Cell

scholarly journals Consecutive Hypoalbuminemia Predicts Inferior Outcome in Patients With Diffuse Large B-Cell Lymphoma

2021 ◽  
Vol 10 ◽  
Author(s):  
Xiaolei Wei ◽  
Jingxia Zheng ◽  
Zewen Zhang ◽  
Qiongzhi Liu ◽  
Minglang Zhan ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Serum Albumin ◽  
B Cell ◽  
Validation Cohort ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Training Cohort ◽  
Large B Cell Lymphoma ◽  
Large B Cell ◽  
Low Serum

The prognostic value of albumin changes between diagnosis and end-of-treatment (EoT) in diffuse large B-cell lymphoma (DLBCL) remains unknown. We retrospectively analyzed 574 de novo DLBCL patients treated with R-CHOP from our and two other centers. All patients were divided into a training cohort (n = 278) and validation cohort (n = 296) depending on the source of the patients. Overall survival (OS) and progression-free survival (PFS) were analyzed by the method of Kaplan–Meier and Cox proportional hazard regression model. In the training cohort, 163 (58.6%) patients had low serum albumin at diagnosis, and 80 of them were present with consecutive hypoalbuminemia at EoT. Patients with consecutive hypoalbuminemia showed inferior OS and PFS (p = 0.010 and p = 0.079, respectively). Similar survival differences were also observed in the independent validation cohort (p = 0.006 and p = 0.030, respectively). Multivariable analysis revealed that consecutive hypoalbuminemia was an independent prognostic factor OS [relative risk (RR), 2.249; 95% confidence interval (CI), 1.441–3.509, p < 0.001] and PFS (RR, 2.001; 95% CI, 1.443–2.773, p < 0.001) in all DLBCL patients independent of IPI. In conclusion, consecutive hypoalbuminemia is a simple and effective adverse prognostic factor in patients with DLBCL, which reminds us to pay more attention to patients with low serum albumin at EoT during follow-up.

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