scholarly journals Immune Responses of Chickens Infected with Wild Bird-Origin H5N6 Avian Influenza Virus

2017 ◽  
Vol 8 ◽  
Author(s):  
Shimin Gao ◽  
Yinfeng Kang ◽  
Runyu Yuan ◽  
Haili Ma ◽  
Bin Xiang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Immune Responses ◽  
Avian Influenza Virus ◽  
Wild Bird

scholarly journals Characterization of Host Responses against a Recombinant Fowlpox Virus-Vectored Vaccine Expressing the Hemagglutinin Antigen of an Avian Influenza Virus

2010 ◽  
Vol 17 (3) ◽  
pp. 454-463 ◽  
Author(s):  
Hamid R. Hghihghi ◽  
Leah R. Read ◽  
Hakimeh Mohammadi ◽  
Yanlong Pei ◽  
Claudia Ursprung ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Immune Responses ◽  
Avian Influenza Virus ◽  
Cultured Cells ◽  
Type I Interferons ◽  
Host Responses ◽  
Type I ◽  
Fowlpox Virus ◽  
Time Points

ABSTRACT There currently are commercial fowlpox virus (FPV)-vectored vaccines for use in chickens, including TROVAC-AIV H5, which expresses the hemagglutinin (HA) antigen of an avian influenza virus and can confer immunity against avian influenza in chickens. Despite the use of recombinant FPV (rFPV) for vaccine delivery, very little is known about the immune responses generated by these viruses in chickens. The present study was designed to investigate host responses to rFPV in vivo and in vitro. In cultured cells infected with TROVAC-AIV H5, there was an early increase in the expression of type I interferons (IFN), Toll-like receptors 3 and 7 (TLR3 and TLR7, respectively), TRIF, and MyD88, which was followed by a decrease in the expression of these genes at later time points. There also was an increase in the expression of interleukin-1β (IL-1β), IL-8, and beta-defensin genes at early time points postinfection. In chickens immunized with TROVAC-AIV H5, there was higher expression of IFN-γ and IL-10 at day 5 postvaccination in spleen of vaccinated birds than in that of control birds. We further investigated the ability of the vaccine to induce immune responses against the HA antigen and discovered that there was a cell-mediated response elicited in vaccinated chickens against this antigen. The findings of this study demonstrate that FPV-vectored vaccines can elicit a repertoire of responses marked by the early expression of TLRs, type I interferons, and proinflammatory cytokines, as well as cytokines associated with adaptive immune responses. This study provides a platform for designing future generations of rFPV-vectored vaccines.

scholarly journals Characterization of an Avian Influenza Virus H9N2 Strain Isolated from Dove in Southern China

2018 ◽  
Vol 6 (18) ◽  
pp. e00369-18 ◽  
Author(s):  
Dan Li ◽  
ZhengTing Li ◽  
Zhixun Xie ◽  
Meng Li ◽  
Zhiqin Xie ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Wild Bird ◽  
Southern China

ABSTRACT We report here the complete genome sequence of strain H9N2, an avian influenza virus (AIV) isolated from dove in Guangxi, China. Phylogenetic analysis showed that it was a novel reassortant AIV derived from chicken, duck, and wild bird. This finding provides useful information for understanding the H9N2 subtype of AIV circulating in southern China.

Increased Pathogenicity and Shedding in Chickens of a Wild Bird–Origin Low Pathogenicity Avian Influenza Virus of the H7N3 Subtype Following MultipleIn VivoPassages in Quail and Turkey

2010 ◽  
Vol 54 (s1) ◽  
pp. 555-557 ◽  
Author(s):  
Filippo Cilloni ◽  
Anna Toffan ◽  
Simone Giannecchini ◽  
Valeria Clausi ◽  
Alberta Azzi ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Wild Bird

scholarly journals Molecular analysis of highly pathogenic avian influenza virus of subtype H5N1 isolated from wild birds and mammals in northern Germany

2007 ◽  
Vol 88 (2) ◽  
pp. 554-558 ◽  
Author(s):  
Siegfried Weber ◽  
Timm Harder ◽  
Elke Starick ◽  
Martin Beer ◽  
Ortrud Werner ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Amino Acid ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Wild Bird ◽  
Highly Pathogenic Avian Influenza ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
H5n1 Isolate ◽  
Pathogenic Avian Influenza Virus

Analysis of the full-length sequences of all eight segments of the German wild-bird H5N1 highly pathogenic avian influenza virus index isolate, A/Cygnus cygnus/Germany/R65/2006, and an H5N1 isolate from a cat (A/cat/Germany/R606/2006) obtained during an outbreak in February 2006 revealed a very high similarity between these two sequences. One amino acid substitution in the PA gene, encoding a protein involved in virus RNA replication, and one amino acid substitution in the haemagglutinin (HA) protein were observed. Phylogenetic analyses of the HA and neuraminidase nucleotide sequences showed that avian influenza H5N1 isolates from the Astrakhan region located in southern Russia were the closest relatives. Reassortment events could be excluded in comparison with other ‘Qinghai-like’ H5N1 viruses. In addition, an H5N1 isolate originating from a single outbreak in poultry in Germany was found to be related closely to the H5N1 viruses circulating at that time in the wild-bird population.

Spatial Modeling of Wild Bird Risk Factors for Highly Pathogenic A(H5N1) Avian Influenza Virus Transmission

2016 ◽  
Vol 60 (1s) ◽  
pp. 329-336 ◽  
Author(s):  
Diann J. Prosser ◽  
Laura L. Hungerford ◽  
R. Michael Erwin ◽  
Mary Ann Ottinger ◽  
John Y. Takekawa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Spatial Modeling ◽  
Wild Bird ◽  
Virus Transmission ◽  
Highly Pathogenic ◽  
H5n1 Avian Influenza Virus ◽  
H5n1 Avian Influenza

Application of DNA Barcoding Technique in Avian Influenza Virus Surveillance of Wild Bird Habitats in Korea and Mongolia

2010 ◽  
Vol 5 (s1) ◽  
pp. e160-e161
Author(s):  
Dong-Hun Lee ◽  
Hyun-Jeong Lee ◽  
Yu-Na Lee ◽  
Youn-Jeong Lee ◽  
Ok-Mi Jeong ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Dna Barcoding ◽  
Wild Bird ◽  
Virus Surveillance

scholarly journals Isolation and characterization of low pathogenic H7N7 avian influenza virus from a red-crowned crane in a zoo in South Korea

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Young-Jae Si ◽  
Yu-Na Lee ◽  
Sun-Ha Cheon ◽  
Yu-Ri Park ◽  
Yoon-Gi Baek ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
South Korea ◽  
Avian Influenza Virus ◽  
Wild Bird ◽  
Wild Birds ◽  
Nucleotide Sequencing ◽  
Isolation And Characterization ◽  
Constellation Analysis ◽  
Surveillance Programs

Abstract Background South Korea conducts annual national surveillance programs to detect avian influenza (AI) in domestic poultry, live bird markets, and wild birds. In March 2017, an AIV was isolated from fecal samples in an outdoor aviary flight cage in a zoo in Korea. Results Nucleotide sequencing identified the isolate as low pathogenic avian influenza virus (LPAIV) H7N7, and DNA barcoding analysis identified the host species as red-crowned crane. This isolate was designated A/red-crowned crane/Korea/H1026/2017 (H7N7). Genetic analysis and gene constellation analysis revealed that A/red-crowned crane/Korea/H1026/2017 (H7N7) showed high similarity with four H7N7 LPAIVs isolated from wild bird habitats in Seoul and Gyeonggi in early 2017. Conclusions Considering the genetic similarity and similar collection dates of the viruses, and the fact that zoo bird cages are vulnerable to AIV, it is likely that fecal contamination from wild birds might have introduced LPAIV H7N7 into the red-crowned crane at the zoo. Therefore, our results emphasize that enhanced biosecurity measures should be employed during the wild bird migration season, and that continued surveillance should be undertaken to prevent potential threats to avian species in zoos and to humans.

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