scholarly journals Berberine Relieves Metabolic Syndrome in Mice by Inhibiting Liver Inflammation Caused by a High-Fat Diet and Potential Association With Gut Microbiota

2022 ◽  
Vol 12 ◽  
Author(s):  
Jinjin Li ◽  
Jialin Li ◽  
Jiajia Ni ◽  
Caibo Zhang ◽  
Jianlei Jia ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Inflammatory Response ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Liver Fat ◽  
Lipid Lowering ◽  
Inflammatory Factor ◽  
High Fat ◽  
Host Inflammatory Response ◽  
Microbiota Structure

Whether berberine mediates its anti-inflammatory and blood sugar and lipid-lowering effects solely by adjusting the structure of the gut microbiota or by first directly regulating the expression of host pro-inflammatory proteins and activation of macrophages and subsequently acting on gut microbiota, is currently unclear. To clarify the mechanism of berberine-mediated regulation of metabolism, we constructed an obese mouse model using SPF-grade C57BL/6J male mice and conducted a systematic study of liver tissue pathology, inflammatory factor expression, and gut microbiota structure. We screened the gut microbiota targets of berberine and showed that the molecular mechanism of berberine-mediated treatment of metabolic syndrome involves the regulation of gut microbiota structure and the expression of inflammatory factors. Our results revealed that a high-fat diet (HFD) significantly changed mice gut microbiota, thereby probably increasing the level of toxins in the intestine, and triggered the host inflammatory response. The HFD also reduced the proportion of short-chain fatty acid (SCFA)-producing genes, thereby hindering mucosal immunity and cell nutrition, and increased the host inflammatory response and liver fat metabolism disorders. Further, berberine could improve the chronic HFD-induced inflammatory metabolic syndrome to some extent and effectively improved the metabolism of high-fat foods in mice, which correlated with the gut microbiota composition. Taken together, our study may improve our understanding of host-microbe interactions during the treatment of metabolic diseases and provide useful insights into the action mechanism of berberine.

scholarly journals Chitosan Oligosaccharide Ameliorates Metabolic Syndrome Induced by Overnutrition via Altering Intestinal Microbiota

2021 ◽  
Vol 8 ◽  
Author(s):  
Yihua Wang ◽  
Shili Liu ◽  
Di Tang ◽  
Rui Dong ◽  
Qiang Feng
Keyword(s):  
Metabolic Syndrome ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Lipid Lowering ◽  
Positive Interactions ◽  
High Fat ◽  
Low Fat ◽  
Low Fat Diet ◽  
Clostridium Paraputrificum

Chitosan oligosaccharides (COS) play a prebiotic role in many ways, whereas its function on microbiota is not fully understood. In this study, the effects of COS on metabolic syndrome were initially investigated by testing changes in the physiological indicators after adding COS to the diet of mice with high fat (group H) and low fat (group L). The results showed that COS markedly inhibited the accumulation of body weight and liver fat induced by high-fat diet, as well as restored the elevated concentration of blood glucose and fasting insulin to normal levels. Next, changes of the murine intestinal microbiota were examined. The results exhibited that COS reduced with-in-sample diversity, while the between-sample microbial diversity enhanced. Specifically, COS enriched Clostridium paraputrificum and Clostridium ramosum in the mice on a high-fat diet, while the abundance of Clostridium cocleatum was reduced. As a comparison, Parabacteroides goldsteinii and Bacteroides uniformis increased their abundance in response to COS in the low-fat diet group. Noticeably, a large amount of Akkermansia muciniphila was enriched in both high-fat or low-fat diet groups. Among the differential fecal bacteria, Clostridium ramosume was found to be positively interacted with Faecalibacterim prausnitzii and Clostridium paraputrificum; Clostridium paraputrificum had a positive interactions with Lactococcus chungangensis and Bifidobacterium mongoliense, suggesting that COS probably ameliorate metabolic syndrome through the microbiota in view of the lipid-lowering effects of these interacted bacteria. Furthermore, the gene expression data revealed that COS improved the functions related to intestinal barrier and glucose transport, which could be the trigger and consequence of the variations in gut microbiota induced by COS. Additionally, correlation analysis found that intestinal bacteria are related to physiological parameters, which further supports the mediating role of gut microbiota in the beneficial effect of COS. In summary, our research results provide new evidence for the prebiotic effects of COS.

Polysaccharide from Flammulina velutipes Attenuates Markers of Metabolic Syndrome by modulating the Gut Microbiota and Lipid Metabolism in High fat Diet-fed Mice

2021 ◽  
Author(s):  
Ruiqiu Zhao ◽  
Yang Ji ◽  
Xin Chen ◽  
Qiuhui Hu ◽  
Liyan Zhao
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Flammulina Velutipes ◽  
Biological Macromolecules ◽  
High Fat

Natural biological macromolecules with putative functions of gut microbiota regulation possesses the advantage in improving metabolic syndrome (MS). In this research, we aimed to determine the effects of Flammulina velutipes...

scholarly journals Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice

2014 ◽  
Vol 9 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Jingjing Wang ◽  
Huang Tang ◽  
Chenhong Zhang ◽  
Yufeng Zhao ◽  
Muriel Derrien ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
High Fat

Low molecular weight chitosan oligosaccharides (LMW-COSs) prevent obesity-related metabolic abnormalities in association with the modification of gut microbiota in high-fat diet (HFD)-fed mice

2020 ◽  
Vol 11 (11) ◽  
pp. 9947-9959
Author(s):  
Ningning He ◽  
Shuo Wang ◽  
Zhiyuan Lv ◽  
Wandong Zhao ◽  
Shangyong Li
Keyword(s):  
Molecular Weight ◽  
Inflammatory Response ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Parameters ◽  
Low Molecular Weight ◽  
Metabolic Abnormalities ◽  
High Fat ◽  
Chitosan Oligosaccharides ◽  
Low Molecular Weight Chitosan

Enzymatic LMW-COSs ameliorate obesity and obesity-related metabolic abnormalities. The overall change in gut microbiota was associated with metabolic parameters and its prebiotic functions by regulating gut microbiota and inflammatory response.

Ophiopogonin D alleviates high‐fat diet‐induced metabolic syndrome and changes the structure of gut microbiota in mice

2018 ◽  
Vol 32 (3) ◽  
pp. 1139-1153 ◽  
Author(s):  
Siyu Chen ◽  
Xiao Li ◽  
Li Liu ◽  
Chang Liu ◽  
Xiao Han
Keyword(s):  
Metabolic Syndrome ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
High Fat
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