Striking Dependence of Protein Sweetness on Water Quality: The Role of the Ionic Strength

Frontiers in Molecular Biosciences ◽

10.3389/fmolb.2021.705102 ◽

2021 ◽

Vol 8 ◽

Author(s):

Masoud Delfi ◽

Alessandro Emendato ◽

Piero Andrea Temussi ◽

Delia Picone

Keyword(s):

Water Quality ◽

Ionic Strength ◽

Mechanism Of Action ◽

Experimental Validation ◽

Food Additives ◽

Water Salinity ◽

Sweet Proteins

Sweet proteins are the sweetest natural molecules. This aspect prompted several proposals for their use as food additives, mainly because the amounts to be added to food would be very small and safe for people suffering from sucrose-linked diseases. During studies of sweet proteins as food additives we found that their sweetness is affected by water salinity, while there is no influence on protein’s structure. Parallel tasting of small size sweeteners revealed no influence of the water quality. This result is explained by the interference of ionic strength with the mechanism of action of sweet proteins and provides an experimental validation of the wedge model for the interaction of proteins with the sweet receptor.

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SOME ASPECTS OF THE FUNCTION OF FSH- AND LH-LIKE HORMONES IN NORMAL AND HYPOPHYSECTOMIZED FEMALE RATS, IN CONNECTION WITH RESERPINE ADMINISTRATION

Acta Endocrinologica ◽

10.1530/acta.0.0490028 ◽

1965 ◽

Vol 49 (1) ◽

pp. 28-38

Author(s):

M. Grönroos ◽

E. Mäkinen ◽

K. Lahtinen ◽

R. Tirri

Keyword(s):

Mechanism Of Action ◽

Biological Effect ◽

Female Rats ◽

Histological Picture ◽

Peripheral Effect ◽

Pituitary Secretion

ABSTRACT The effect of reserpine on the secretion of FSH and LH was studied as well as the role of the peripheral effect of reserpine after hypophysectomy. The results in the unoperated animals suggest that reserpine inhibits the pituitary secretion of both FSH and LH. Both these hormones combined with reserpine had a very different biological effect than was seen without reserpine. HCG (LH-like) and particularly PMS (FSH-like) hormones combined with reserpine caused definite enlargement of the ovaries. In the hypophysectomized groups, the effect of the PMS and HCG hormones administered together with reserpine or without it was the same with regard to the weight of the ovaries, but not with regard to their histological picture. On the basis of these results, reserpine may be said to have a peripheral effect although the nature of its mechanism of action is difficult to state. Reserpine probably affects the ovaries by inhibiting the follicular cycle and, consequently, the formation of new and more mature follicles.

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THE ROLE OF PATCH TESTING FOR FOOD ADDITIVES IN CHILDREN WITH ATOPIC DERMATITIS

10.26226/morressier.5afda3c8d64f25002cfc3cc8 ◽

2018 ◽

Author(s):

A. Kocak

Keyword(s):

Atopic Dermatitis ◽

Patch Testing ◽

Food Additives

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Role of Flavonoids in Neurodegenerative Disorders with Special Emphasis on Tangeritin

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527318666190916141934 ◽

2019 ◽

Vol 18 (8) ◽

pp. 581-597 ◽

Cited By ~ 1

Author(s):

Ambreen Fatima ◽

Yasir Hasan Siddique

Keyword(s):

Medicinal Plants ◽

Mechanism Of Action ◽

Neurodegenerative Disorders ◽

Treatment Strategies ◽

Dietary Supplementation ◽

Plant Polyphenols ◽

Promising Candidate ◽

Naturally Occurring ◽

The Brain

Flavonoids are naturally occurring plant polyphenols found universally in all fruits, vegetables and medicinal plants. They have emerged as a promising candidate in the formulation of treatment strategies for various neurodegenerative disorders. The use of flavonoid rich plant extracts and food in dietary supplementation have shown favourable outcomes. The present review describes the types, properties and metabolism of flavonoids. Neuroprotective role of various flavonoids and the possible mechanism of action in the brain against the neurodegeneration have been described in detail with special emphasis on the tangeritin.

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