scholarly journals Mild cognitive impairment, poor episodic memory, and late-life depression are associated with cerebral cortical thinning and increased white matter hyperintensities

2014 ◽  
Vol 6 ◽  
Author(s):  
Motonobu Fujishima ◽  
Norihide Maikusa ◽  
Kei Nakamura ◽  
Masahiro Nakatsuka ◽  
Hiroshi Matsuda ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Episodic Memory ◽  
White Matter Hyperintensities ◽  
Late Life ◽  
Late Life Depression ◽  
Cortical Thinning

scholarly journals Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment

2019 ◽  
Vol 75 (7) ◽  
pp. 1382-1392 ◽  
Author(s):  
Marie Caillaud ◽  
Carol Hudon ◽  
Benjamin Boller ◽  
Simona Brambati ◽  
Simon Duchesne ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Episodic Memory ◽  
Cognitive Decline ◽  
White Matter Hyperintensities ◽  
Hippocampal Volume ◽  
Subjective Cognitive Decline

Abstract Objective The concepts of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have been proposed to identify individuals in the early stages of Alzheimer’s disease (AD), or other neurodegenerative diseases. One approach to validate these concepts is to investigate the relationship between pathological brain markers and cognition in those individuals. Method We included 126 participants from the Consortium for the Early Identification of Alzheimer’s disease-Quebec (CIMA-Q) cohort (67 SCD, 29 MCI, and 30 cognitively healthy controls [CH]). All participants underwent a complete cognitive assessment and structural magnetic resonance imaging. Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs). Results Significant differences were found between participants with MCI and CH on episodic and executive tasks, but no differences were found when comparing SCD and CH. Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups. Discussion As expected, the SCD group was shown to be cognitively healthy on tasks where MCI participants showed impairment. However, SCD’s hippocampal volume related to episodic memory performances, and WMH to executive functions. Thus, SCD represents a valid research concept and should be used, alongside MCI, to better understand the preclinical/prodromal phase of AD.

scholarly journals Effects of the coexistence of late-life depression and mild cognitive impairment on white matter microstructure

2014 ◽  
Vol 338 (1-2) ◽  
pp. 46-56 ◽  
Author(s):  
Wenjun Li ◽  
L. Tugan Muftuler ◽  
Gang Chen ◽  
B. Douglas Ward ◽  
Matthew D. Budde ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Late Life ◽  
Late Life Depression ◽  
White Matter Microstructure

SERIAL POSITION PROFILES OF RECALL IN MILD COGNITIVE IMPAIRMENT: INTERPLAY BETWEEN HIPPOCAMPAL VOLUMES AND WHITE MATTER HYPERINTENSITIES

2017 ◽  
Vol 13 (7) ◽  
pp. P548-P550
Author(s):  
Russell J. Chander ◽  
Heidi Emmanuel Foo ◽  
Ting Ting Yong ◽  
Levinia Lim ◽  
Jayne Yi Tan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Serial Position ◽  
White Matter Hyperintensities

T111. Changes in Connectivity Induced by White Matter Hyperintensities Predict Dysexecutive Behaviors in Late-Life Depression

2018 ◽  
Vol 83 (9) ◽  
pp. S171
Author(s):  
Matteo Respino ◽  
Amy Kuceyeski ◽  
Matthew Hoptman ◽  
Lindsay Victoria ◽  
Matthew Scult ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Late Life ◽  
Late Life Depression
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