scholarly journals A Potential Association Between Retinal Changes, Subjective Memory Impairment, and Anxiety in Older Adults at Risk for Alzheimer’s Disease: A 27-Month Pilot Study

2019 ◽  
Vol 11 ◽  
Author(s):  
Derrick L. Cheng ◽  
Louisa Thompson ◽  
Peter J. Snyder
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Pilot Study ◽  
Memory Impairment ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Potential Association

scholarly journals Family History of Alzheimer’s Disease and Subjective Memory Performance

2018 ◽  
Vol 33 (7) ◽  
pp. 458-462 ◽  
Author(s):  
Robert Haussmann ◽  
Steffi Ganske ◽  
Antonia Gruschwitz ◽  
Annett Werner ◽  
Antje Osterrath ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Family History ◽  
Cognitive Deficits ◽  
Memory Impairment ◽  
Subjective Memory ◽  
Healthy Older Adults ◽  
Subjective Memory Impairment ◽  
History Of

People with a first-degree family history of Alzheimer’s disease are at an increased risk of developing dementia. Subjective memory impairment among individuals with no measurable cognitive deficits may also indicate elevated dementia risk. It remains unclear whether nondemented people with a positive family history of Alzheimer’s disease are more likely to experience cognitive deficits and whether such an association reflects underlying neuropathology. We therefore investigated subjective memory impairment and hippocampal cortical thickness in 40 healthy older adults and 35 patients with amnestic mild cognitive impairment. We found greater subjective memory impairment and left hemispheric hippocampal cortical thinning associated with a first-degree family history of Alzheimer’s disease in healthy older adults. This suggests that subjective memory impairment could reflect preclinical stage neurodegeneration among individuals with the family history risk factor.

The Modulatory Effect of Sex on the Association between APOE and Neuropsychiatric Symptom Burden in Older Adults at Risk for Alzheimer's Disease.

2021 ◽  
Vol 29 (4) ◽  
pp. S51
Author(s):  
Andrew Dissanayake ◽  
Cristopher R. Bowie ◽  
Meryl A. Butters ◽  
Alastair Flint ◽  
Damien Gallagher ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Symptom Burden ◽  
Neuropsychiatric Symptom

scholarly journals The Meta-Memory Ratio: A new cohort-independent way to measure cognitive awareness in asymptomatic individuals at risk for Alzheimer’s disease

2020 ◽  
Author(s):  
Geoffroy Pierre Gagliardi ◽  
Marion Houot ◽  
Federica Cacciamani ◽  
Marie-Odile Habert ◽  
Bruno Dubois ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Clinical Care ◽  
Subjective Memory ◽  
Cerebral Amyloidosis ◽  
Cognitive Awareness ◽  
Amyloid Load ◽  
Asymptomatic Individuals ◽  
The Impact

Abstract Background Lack of Awareness for Cognitive Decline (ACD) has been described at the preclinical and prodromal stages of Alzheimer’s disease (AD). In this study, we introduced a meta-memory ratio (MMR), and explored how it is associated with neuroimaging AD biomarkers in asymptomatic individuals at risk for AD. Method 448 cognitively healthy participants from two cohorts of subjective memory complainers (INSIGHT-PreAD and ADNI) were included. Regression models were used to assess the impact of AD biomarkers on the MMR. Result In both cohorts, there was a significant quadratic effect of cerebral amyloidosis on the MMR value. In particular, participants had a high ACD up to the amyloid positivity threshold, above which a decrease of ACD was eventually observed as the amyloid load increased. Conclusion This nonlinear evolution of ACD in very early AD must be taken into account in clinical care and for trial enrollment as well.

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