scholarly journals Correlation Between Gait and Near-Infrared Brain Functional Connectivity Under Cognitive Tasks in Elderly Subjects With Mild Cognitive Impairment

2021 ◽  
Vol 13 ◽  
Author(s):  
Ying Liu ◽  
Congcong Huo ◽  
Kuan Lu ◽  
Qianying Liu ◽  
Gongcheng Xu ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Prefrontal Cortex ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Motor Cortex ◽  
Low Frequency ◽  
Frequency Interval ◽  
Gait Symmetry ◽  
Brain Functional Connectivity

Older adults with mild cognitive impairment (MCI) have a high risk of developing Alzheimer’s disease. Gait performance is a potential clinical marker for the progression of MCI into dementia. However, the relationship between gait and brain functional connectivity (FC) in older adults with MCI remains unclear. Forty-five subjects [MCI group, n = 23; healthy control (HC) group, n = 22] were recruited. Each subject performed a walking task (Task 01), counting backward–walking task (Task 02), naming animals–walking task (Task 03), and calculating–walking task (Task 04). The gait parameters and cerebral oxygenation signals from the left prefrontal cortex (LPFC), right prefrontal cortex (RPFC), left motor cortex (LMC), right motor cortex (RMC), left occipital leaf cortex (LOL), and right occipital leaf cortex (ROL) were obtained simultaneously. Wavelet phase coherence was calculated in two frequency intervals: low frequency (interval I, 0.052–0.145 Hz) and very low frequency (interval II, 0.021–0.052 Hz). Results showed that the FC of RPFC–RMC is significantly lower in interval I in Task 03 compared with that in Task 02 in the MCI group (p = 0.001). Also, the right relative symmetry index (IDpsR) is significantly lower in Task 03 compared with that in Task 02 (p = 0.000). The IDpsR is positively correlated with the FC of RPFC–RMC in interval I in the MCI group (R = 0.205, p = 0.041). The gait symmetry such as left relative symmetry index (IDpsL) and IDpsR is significantly lower in the dual-task (DT) situation compared with the single task in the two groups (p < 0.05). The results suggested that the IDpsR might reflect abnormal change in FC of RPFC–RMC in interval I in the MCI population during Task 03. The gait symmetry is affected by DTs in both groups. The findings of this study may have a pivotal role in the early monitoring and intervention of brain dysfunction among older adults with MCI.

P1-386: AMYLOID AND CEREBROVASCULAR BURDEN INFLUENCES ON LONGITUDINAL BRAIN FUNCTIONAL CONNECTIVITY CHANGES IN MILD COGNITIVE IMPAIRMENT

2006 ◽  
Vol 14 (7S_Part_8) ◽  
pp. P448-P449
Author(s):  
Joanna Su Xian Chong ◽  
Hyemin Jang ◽  
Hee Jin Kim ◽  
Duk L. Na ◽  
Jae-Hong Lee ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Brain Functional Connectivity

scholarly journals Brain Functional Connectivity Changes in Middle-Aged Hong Chuan Tai Chi Players

2021 ◽  
Author(s):  
Zhenguo Shi ◽  
Lei Xu ◽  
Hui Xie ◽  
Xiangliang Zhang ◽  
Qiang He
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Motor Cortex ◽  
Tai Chi ◽  
Cerebral Oxygenation ◽  
Occipital Cortex ◽  
Middle Aged ◽  
Left And Right ◽  
Global Cognition ◽  
Brain Functional Connectivity

Abstract Tai Chi has been shown an effective strategy to improve cognitive function in older populations while the underlying mechanism remains unclear. This cross-sectional study was performed to examine the brain functional connectivity changes in middle-aged Hong Chuan Tai Chi practitioners. The changes in cerebral oxygenation were measured by functional near-infrared spectroscopy. NIRS signals were obtained from left and right prefrontal cortex, motor cortex and occipital cortex in 18 Hong chuan Tai Chi practitioners (age:55.78 ± 2.64y) and 22 demographically matched healthy Tai Chi-naïve controls (age:54.69 ± 3.10y). Global cognition was measured by the Montreal Cognitive Assessment Scale, and spontaneous oscillations in cerebral oxygenation between three cortexes in five frequency intervals (I, 0.6-2Hz; II, 0.145-0.6Hz; III, 0.052-0.145Hz; IV, 0.021-0.052Hz; V, 0.0095-0.021Hz) was analyzed by wavelet phase coherence. Compared with age-matched Tai Chi-naïve controls, Hong Chuan Tai Chi practitioners had better global cognition, showed higher functional connectivity between left and right prefrontal cortex, motor cortex, occipital cortex in intervals I, III, VI and V. These findings showed that middle-aged Hong Chuan Tai Chi practitioners had higher functional connectivity between prefrontal cortex, motor cortex and occipital cortex, as well as the coordination of left and right brain, which maybe the contributing factors to higher global cognition.

Functional connectivity underpinning changes in life-space mobility in older adults with mild cognitive impairment: A 12-month prospective study

2020 ◽  
Vol 378 ◽  
pp. 112216 ◽  
Author(s):  
Chun Liang Hsu ◽  
Rachel Crockett ◽  
Patrick Chan ◽  
Lisanne ten Brinke ◽  
Stephanie Doherty ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Prospective Study ◽  
Life Space

scholarly journals Preventing Loss of Independence through Exercise (PLIÉ): A Pilot Trial in Older Adults with Subjective Memory Decline and Mild Cognitive Impairment

2021 ◽  
pp. 1-15
Author(s):  
Linda L. Chao ◽  
Jennifer A. Lee ◽  
Steven Martinez ◽  
Cody Barlow ◽  
Margaret A. Chesney ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Social Isolation ◽  
Self Regulation ◽  
Pilot Trial ◽  
Well Being ◽  
Subjective Memory ◽  
Memory Decline

Background: Preventing Loss of Independence through Exercise (PLIÉ) is a group movement program initially developed for people with mild-to-moderate dementia that integrates principles from several well-established traditions to specifically addresses the needs of people with cognitive impairment. Objective: To investigate whether PLIÉ would benefit cognitive and behavioral outcomes and functional brain connectivity in older adults with milder forms of cognitive impairment. Methods: Participants (≥55 y) with subjective memory decline (SMD) or mild cognitive impairment (MCI) were assessed with tests of cognitive and physical function, self-report questionnaires, and resting state functional magnetic resonance imaging (rs-fMRI) on a 3 Tesla scanner before and after participating in twice weekly PLIÉ classes for 12 weeks at the San Francisco Veterans Affairs Medical Center. Results: Eighteen participants completed the pre-post intervention pilot trial. We observed significant improvements on the Alzheimer’s Disease Assessment Scale cognitive subscale (ADAS-cog; effect size 0.34, p = 0.002) and enhanced functional connections between the medial prefrontal cortex (mPFC) and other nodes of the default mode network (DMN) after PLIÉ. Improvements (i.e., lower scores) on ADAS-cog were significantly correlated with enhanced functional connectivity between the mPFC and left lateral parietal cortex (Spearman’s ρ= –0.74, p = 0.001) and between the mPFC and right hippocampus (Spearman’s ρ= –0.83, p = 0.001). After completing PLIÉ, participants reported significant reductions in feelings of social isolation and improvements in well-being and interoceptive self-regulation. Conclusion: These preliminary findings of post-PLIÉ improvements in DMN functional connectivity, cognition, interoceptive self-regulation, well-being and reduced feelings of social isolation warrant larger randomized, controlled trials of PLIÉ in older adults with SMD and MCI.

Sign in / Sign up

Export Citation Format

Share Document