scholarly journals Skin Cancer May Delay Onset but Not Progression of Parkinson's Disease: A Nested Case-Control Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Abhimanyu Mahajan ◽  
Martina Chirra ◽  
Alok K. Dwivedi ◽  
Andrea Sturchio ◽  
Elizabeth G. Keeling ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Skin Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Prodromal symptoms and early detection of Parkinson's disease in general practice: a nested case-control study

2014 ◽  
Vol 31 (4) ◽  
pp. 373-378 ◽  
Author(s):  
A. O. A. Plouvier ◽  
R. J. M. G. Hameleers ◽  
E. A. J. van den Heuvel ◽  
H. H. Bor ◽  
T. C. Olde Hartman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
General Practice ◽  
Early Detection ◽  
Case Control Study ◽  
Case Control ◽  
Prodromal Symptoms ◽  
Nested Case Control ◽  
Control Study

scholarly journals Use of non-steroidal anti-inflammatory drugs and risk of Parkinson's disease: nested case-control study

BMJ ◽  
2011 ◽  
Vol 342 (jan20 1) ◽  
pp. d198-d198 ◽  
Author(s):  
J. A. Driver ◽  
G. Logroscino ◽  
L. Lu ◽  
J. M. Gaziano ◽  
T. Kurth
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nested Case Control ◽  
Control Study

β-Adrenoceptor Drugs and Parkinson’s Disease: A Nationwide Nested Case–Control Study

CNS Drugs ◽  
2020 ◽  
Vol 34 (7) ◽  
pp. 763-772
Author(s):  
Sibylle de Germay ◽  
Cécile Conte ◽  
Olivier Rascol ◽  
Jean-Louis Montastruc ◽  
Maryse Lapeyre-Mestre
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Non-motor features of Parkinson’s disease in a nested case–control study of US men

2018 ◽  
Vol 89 (12) ◽  
pp. 1288-1295 ◽  
Author(s):  
Katherine C Hughes ◽  
Xiang Gao ◽  
Jessica M Baker ◽  
Christopher Stephen ◽  
Iris Y Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Rapid Eye Movement Sleep ◽  
Sleep Behaviour ◽  
Nested Case Control ◽  
Control Study ◽  
Smell Identification

BackgroundSeveral non-motor features may individually contribute to identify prodromal Parkinson’s disease (PD), but little is known on how they interact.MethodsWe conducted a case–control study nested within the Health Professionals Follow-up Study in a large cohort of men age 40–75 at recruitment in 1986. Cases (n=120) had confirmed PD, were<85 in January 2012, returned a 2012 questionnaire with questions on probable rapid eye movement sleep behaviour disorder (RBD) and constipation sent to all cohort participants and completed in 2014 the Brief Smell Identification Test and a questionnaire assessing parkinsonism and other non-motor PD features (including depressive symptoms, excessive daytime sleepiness, impaired colour vision and body pain). Controls (n=6479) met the same criteria as cases, except for the PD diagnosis.ResultsConcurrent constipation, probable RBD and hyposmia were present in 29.3% of cases and 1.1% of controls, yielding an age-adjusted OR of 160(95%CI 72.8to353) for three features versus none. The odds of PD increased exponentially with additional non-motor features (OR for 6–7 features versus none: 1325; 95%CI333to5279). Among men without PD, the number of non-motor features was associated with odds of parkinsonism (OR for 6–7 features versus none: 89; 95%CI21.2to375). We estimated that in a population with a prodromal PD prevalence of 2%, concurrent constipation, probable RBD and hyposmia would have a maximum sensitivity of 29% and a positive predictive value (PPV) of 35%. The PPV could increase up to 70% by including additional features, but with sharply decreased sensitivity.ConclusionsConcurrent constipation, probable RBD and hyposmia are strongly associated with PD. Because these features often precede motor symptoms and their co-occurrence could provide an efficient method for early PD identification.

Recurrent falls in Parkinson’s disease after one year of follow-up: A nested case-control study

2016 ◽  
Vol 65 ◽  
pp. 17-24 ◽  
Author(s):  
Tatjana Gazibara ◽  
Darija Kisic Tepavcevic ◽  
Marina Svetel ◽  
Aleksandra Tomic ◽  
Iva Stankovic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Recurrent Falls ◽  
One Year ◽  
Nested Case Control ◽  
Control Study

scholarly journals Telomere length and Parkinson's disease in men: a nested case−control study

2013 ◽  
Vol 21 (1) ◽  
pp. 93-99 ◽  
Author(s):  
M. Schürks ◽  
J. Buring ◽  
R. Dushkes ◽  
J. M. Gaziano ◽  
R. Y. L. Zee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Telomere Length ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study

2018 ◽  
Vol 15 (8) ◽  
pp. 1587 ◽  
Author(s):  
Chang-Kai Chen ◽  
Jing-Yang Huang ◽  
Yung-Tsan Wu ◽  
Yu-Chao Chang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Protective Effect ◽  
Case Control Study ◽  
Case Control ◽  
Research Database ◽  
Dental Scaling ◽  
Increased Risk ◽  
Nested Case Control ◽  
Control Study

The protective effect of dental scaling in Parkinson’s disease (PD) remains inconclusive. The aim of this study was to analyze the association between dental scaling and the development of PD. A retrospective nested case-control study was performed using the National Health Insurance Research Database of Taiwan. The authors identified 4765 patients with newly diagnosed PD from 2005 to 2013 and 19,060 individuals without PD by matching sex, age, and index year. In subgroup 1, with individuals aged 40–69 years, individuals without periodontal inflammatory disease (PID) showed a protective effect of dental scaling against PD development, especially for dental scaling over five consecutive years (adjusted odds ratio = 0.204, 95% CI = 0.047–0.886, p = 0.0399). In general, the protective effect of dental scaling showed greater benefit for individuals with PID than for those without PID, regardless of whether dental scaling was performed for five consecutive years. In subgroup 2, with patients aged ≥70 years, the discontinued (not five consecutive years) scaling showed increased risk of PD. This was the first study to show that patients without PID who underwent dental scaling over five consecutive years had a significantly lower risk of developing PD. These findings emphasize the value of early and consecutive dental scaling to prevent the development of PD.

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