scholarly journals Neurological Sequela of Acute Pesticide Poisoning Among Adults in Central Taiwan

2021 ◽  
Vol 12 ◽  
Author(s):  
Yen-Chung Chen ◽  
Chin-Hsien Lin ◽  
Shey-Lin Wu
Keyword(s):  
Peripheral Neuropathy ◽  
Cognitive Decline ◽  
Brain Imaging ◽  
Basal Ganglion ◽  
Phosphinic Acid ◽  
Neurological Sequela ◽  
Pesticide Poisoning ◽  
Neurological Sequelae ◽  
Central Taiwan ◽  
Acute Pesticide Poisoning

Background and Purpose: Cases of acute pesticide poisoning account for significant morbidity and mortality in developing countries; however, its burden in Taiwan remains unknown. The study examined acute pesticide poisoning (APP) involving adults in the central region of Taiwan, which is a mainly agricultural sub-urban area.Methods: The retrospective study evaluated the outcome and neurological sequelae of patients with APP in a Taiwanese cohort between April 2002 and February 2019. The pesticides were classified according to the Insecticide Resistance Action Committee Mode of Action (MoA) classification. The clinical characteristics, duration of hospitalization (days), follow-up duration (years), in-hospital mortality, neurological sequela, and imaging findings were recorded. Furthermore, multivariate logistic regression analyses were performed.Results: We identified 299 patients with APP comprising 206 (68.9%) adult men with a mean exposure age of 56.4 ± 16.8 years. Paraquat, organophosphates, pyrethroids, carmabates, and phosphinic acid were the most commonly known reported poisoning agents. The mortality rate was highest in users with paraquat (77.1%), followed by phosphinic acid (22.2%), carbamates (16.7%), and organophosphates (15.8%). After a mean follows up of 3.69 ± 2.26 years, the most common neurological sequela was a cognitive decline (56 among 225 survivors, 24.89%), peripheral neuropathy (11 among 225 survivors, 4.89%), tremor (10 among 225 survivors, 4.44%), ataxia (3/225, 1.33%), and parkinsonism feature (2/225, 0.89%). Brain imaging studies revealed basal ganglion lesions on CT or hyperintensity on T2-weighted MRI images in 26 among 46 patients (56.5%). The basal ganglion lesions on brain imaging had a positive correlation with neurological sequelae.Conclusion: Acute pesticide poisoning (APP)-related mortality is high especially paraquat intoxication, and cognitive decline, as well as peripheral neuropathy, were the most common neurological sequelae among survivors, which is highly correlated with basal ganglia lesions on brain imaging.

Biologic therapy-related demyelinating peripheral neuropathy in a child with juvenile idiopathic arthritis

2018 ◽  
pp. 1-2
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Peripheral Neuropathy ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Biologic Therapy ◽  
Tnf Inhibitor ◽  
Neurological Sequelae ◽  
Demyelinating Peripheral Neuropathy ◽  
Necrosis Factor ◽  
Clinical Worsening

Demyelinating peripheral neuropathy has been described in association with tumor necrosis factor (TNF) inhibitors. It is rarely developed after treatment discontinuation. We present the case of a child with juvenile idiopathic arthritis who developed peripheral neuropathy few months after TNF inhibitor withdrawal with clinical worsening of the neurological sequelae while undergoing treatment with abatacept.

scholarly journals Pesticide Use and Self-Reported Symptoms of Acute Pesticide Poisoning among Aquatic Farmers in Phnom Penh, Cambodia

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Hanne Klith Jensen ◽  
Flemming Konradsen ◽  
Erik Jørs ◽  
Jørgen Holm Petersen ◽  
Anders Dalsgaard
Keyword(s):  
Management Practices ◽  
Cross Sectional Study ◽  
Protective Measure ◽  
Pesticide Poisoning ◽  
Sectional Study ◽  
Cross Sectional ◽  
Phnom Penh ◽  
Pesticide Management ◽  
Handling Practices ◽  
Acute Pesticide Poisoning

Organophosphates and carbamates (OPs/CMs) are known for their acetylcholinesterase inhibiting character. A cross-sectional study of pesticide handling practices and self-perceived symptoms of acute pesticide poisoning was conducted using questionnaire-based interviews with 89 pesticide sprayers in Boeung Cheung Ek (BCE) Lake, Phnom Penh, Cambodia. The study showed that 50% of the pesticides used belonged to WHO class I + II and personal protection among the farmers were inadequate. A majority of the farmers (88%) had experienced symptoms of acute pesticide poisoning, and this was significantly associated with the number of hours spent spraying with OPs/CMs (OR = 1.14, CI 95%: 1.02–1.28). The higher educated farmers reduced their risk of poisoning by 55% for each extra personal protective measure they adapted (OR = 0.45, CI 95%: 0.22–0.91). These findings suggest that improving safe pesticide management practices among the farmers and enforcing the effective banning of the most toxic pesticides will considerably reduce the number of acute pesticide poisoning episodes.

scholarly journals Cases of acute pesticide poisoning in Colonia Puerto Pirapó, Itapúa-Paraguay, february 2014

Biomédica ◽  
2017 ◽  
Vol 37 (2) ◽  
Author(s):  
María Esther Pedrozo ◽  
Sandra Ocampos ◽  
Rosa Galeano ◽  
Andrea Ojeda ◽  
Agueda Cabello ◽  
...  
Keyword(s):  
Pesticide Poisoning ◽  
La Red ◽  
Sobre Todo ◽  
Acute Pesticide Poisoning

De las intoxicaciones reportadas en Paraguay, un 13,7 % tiene como agente causal los plaguicidas, destacándose en primer lugar los compuestos organofosforados. Las intoxicaciones con compuestos organofosforados producen la inhibición de la enzima acetilcolinesterasa y pueden generar tres cuadros clínicos: la intoxicación aguda, el síndrome intermedio y una neurotoxicidad tardía. Se presentan 15 casos de intoxicación aguda, diez mujeres y cinco hombres, entre 5 y 67 años de edad, procedentes de una comunidad rural, quienes iniciaron síntomas luego de haber utilizado el agua de la red comunitaria contaminada con plaguicidas. Los síntomas más frecuentes fueron náuseas y vómitos, seguidas de dolor abdominal, cefalea, fiebre, prurito, inyección conjuntival, sudoración. A cinco casos se les realizó análisis de sangre que incluyeron hemograma, perfil renal, perfil hepático y colinesterasa sérica, con resultados dentro de los valores de referencia, solo uno de los casos presentó enzimas hepáticas alteradas. En dos muestras de agua de la red comunitaria se detectó el compuesto organofosforado con ingrediente activo Profenofos. Es fundamental que el personal de atención primaria de la salud, sobre todo en las zonas rurales, sea capaz de identificar los casos de intoxicaciones agudas por plaguicidas de manera oportuna a fin de brindar el tratamiento adecuado.

scholarly journals P2-385: BRAIN IMAGING OF VASCULAR DYSFUNCTION AS AN EARLY BIOMARKER OF COGNITIVE DECLINE

2019 ◽  
Vol 15 ◽  
pp. P751-P751
Author(s):  
Axel Montagne ◽  
Melanie D. Sweeney ◽  
Abhay P. Sagare ◽  
Daniel A. Nation ◽  
Michael G. Harrington ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Brain Imaging ◽  
Vascular Dysfunction ◽  
Early Biomarker

scholarly journals Neurobehavioural symptoms and acute pesticide poisoning: a cross-sectional study among male pesticide applicators selected from three commercial farming systems in Ethiopia

2018 ◽  
Vol 75 (4) ◽  
pp. 283-289 ◽  
Author(s):  
Beyene Negatu ◽  
Roel Vermeulen ◽  
Yalemtshay Mekonnen ◽  
Hans Kromhout
Keyword(s):  
Large Scale ◽  
Pesticide Exposure ◽  
Farming Systems ◽  
Cumulative Exposure ◽  
Small Scale ◽  
Pesticide Poisoning ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Pesticide Applicators ◽  
Acute Pesticide Poisoning

ObjectiveTo estimate prevalence of acute pesticide poisoning (APP) and its association with neurobehavioural symptoms in Ethiopian pesticide applicators.MethodsWe performed a cross-sectional survey among 256 pesticide applicators from small-scale irrigated farms, a large-scale open farm and large-scale greenhouses. APP was ascertained using a modified WHO case definition, and neurobehavioural symptoms were collected with a standardised questionnaire (Q16). Exposure to pesticides was estimated using detailed exposure algorithms specifically developed for Ethiopian farms. Multiple logistic regression models were used to estimate risk of APP and its association with neurobehavioural symptoms.ResultsOverall APP prevalence was 16%. Working as an applicator in greenhouses was strongly associated with APP (OR 3.00, 95% CI 1.38 to 6.54). Estimated annual pesticide exposure was also associated with APP (OR 1.14, 95% CI 1.00 to 1.20). Longer duration of employment appeared to be negatively associated with APP. Having had an APP was strongly associated with reporting more neurobehavioural symptoms (OR 2.15, 95% CI 1.01 to 4.58) independent of cumulative pesticide exposure. Cumulative exposure to pesticides appeared to be associated with neurobehavioural symptoms among applicators without and with APP.ConclusionsWe showed a substantial prevalence of APP that differed between farming systems and was strongly associated with neurobehavioural symptoms. Intensity of exposure was also clearly associated with these symptoms. Reduction and control of occupational exposure to pesticides is urgently needed in Ethiopia.

scholarly journals Prevalence, Circumstances, and Management of Acute Pesticide Poisoning in Hospitals in Kampala City, Uganda

2017 ◽  
Vol 11 ◽  
pp. 117863021772892 ◽  
Author(s):  
Charles Ssemugabo ◽  
Abdullah Ali Halage ◽  
Ruth Mubeezi Neebye ◽  
Victoria Nabankema ◽  
Massy Moses Kasule ◽  
...  
Keyword(s):  
Pesticide Poisoning ◽  
Kampala City ◽  
Acute Pesticide Poisoning

O5-06-05: Mapping functional and structural brain imaging in subjective cognitive decline

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P329-P330
Author(s):  
Yu Sun ◽  
Zhengjia Dai ◽  
Xiaodan Chen ◽  
Yong He ◽  
Ying Han
Keyword(s):  
Cognitive Decline ◽  
Brain Imaging ◽  
Subjective Cognitive Decline ◽  
Structural Brain ◽  
Structural Brain Imaging
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