Cerebral Blood Flow Difference Between Acute and Chronic Tinnitus Perception: A Perfusion Functional Magnetic Resonance Imaging Study

Purpose: The central nervous mechanism of acute tinnitus is different from that of chronic tinnitus, which may be related to the difference of cerebral blood flow (CBF) perfusion in certain regions. To verify this conjecture, we used arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) in this study to compare the CBF alterations of patients with acute and chronic tinnitus.Methods: The current study included patients with chronic tinnitus (n = 35), acute tinnitus (n = 30), and healthy controls (n = 40) who were age-, sex-, and education-matched. All participants underwent MRI scanning and then ASL images were obtained to measure CBF of the entire brain and analyze the differences between groups as well as the correlations with tinnitus characteristics.Results: The chronic tinnitus group showed increased z-CBF in the right superior temporal gyrus (STG) and superior frontal gyrus (SFG) when compared with the acute tinnitus patients. Further connectivity analysis found enhanced CBF connectivity between the right STG and fusiform gyrus (FG), the right SFG and left middle occipital gyrus (MOG), as well as the right parahippocampal gyrus (PHG). Moreover, in the chronic tinnitus group, the tinnitus handicap questionnaire (THQ) score was positively correlated with the normalized z-CBF of right STG (r = 0.440, p = 0.013).Conclusion: Our results confirmed that the CBF changes in some brain regions were different between acute and chronic tinnitus patients, which was correlated with certain tinnitus characteristics. This is of great value to further research on chronicity of tinnitus, and ASL has a promising application in the measurement of CBF.

Download Full-text

Resting cerebral blood flow alterations specific to the comitant exophoria patients revealed by arterial spin labeling perfusion magnetic resonance imaging

Microvascular Research ◽

10.1016/j.mvr.2018.06.007 ◽

2018 ◽

Vol 120 ◽

pp. 67-73 ◽

Cited By ~ 1

Author(s):

Xin Huang ◽

Sheng Zhou ◽

Ting Su ◽

Lei Ye ◽

Pei-Wen Zhu ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Magnetic Resonance ◽

Arterial Spin Labeling ◽

Spin Labeling ◽

Perfusion Magnetic Resonance Imaging ◽

Resonance Imaging

Download Full-text

Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Reveals Resting Cerebral Blood Flow Alterations Specific to Retinitis Pigmentosa Patients

Current Eye Research ◽

10.1080/02713683.2019.1649702 ◽

2019 ◽

Vol 44 (12) ◽

pp. 1353-1359 ◽

Cited By ~ 1

Author(s):

Handong Dan ◽

Yin Shen ◽

Xin Huang ◽

Fuqing Zhou ◽

Yiqiao Xing

Keyword(s):

Magnetic Resonance Imaging ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Magnetic Resonance ◽

Retinitis Pigmentosa ◽

Arterial Spin Labeling ◽

Spin Labeling ◽

Perfusion Magnetic Resonance Imaging ◽

Resonance Imaging

Download Full-text

Dynamic Susceptibility Contrast Perfusion Magnetic Resonance Imaging Demonstrates Reduced Periventricular Cerebral Blood Flow in Dogs with Ventriculomegaly

Frontiers in Veterinary Science ◽

10.3389/fvets.2017.00137 ◽

2017 ◽

Vol 4 ◽

Cited By ~ 2

Author(s):

Martin J. Schmidt ◽

Malgorzata Kolecka ◽

Robert Kirberger ◽

Antje Hartmann

Keyword(s):

Magnetic Resonance Imaging ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Magnetic Resonance ◽

Perfusion Magnetic Resonance Imaging ◽

Dynamic Susceptibility ◽

Resonance Imaging ◽

Dynamic Susceptibility Contrast ◽

Susceptibility Contrast ◽

Dynamic Susceptibility Contrast Perfusion

Download Full-text

Altered Flow Territories after Extracranial-Intracranial Bypass Surgery

Neurosurgery ◽

10.1227/01.neu.0000170563.70822.10 ◽

2005 ◽

Vol 57 (3) ◽

pp. 486-494 ◽

Cited By ~ 39

Author(s):

Jeroen Hendrikse ◽

Albert van der Zwan ◽

Lino M.P. Ramos ◽

Matthias J.P. van Osch ◽

Xavier Golay ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Magnetic Resonance ◽

Arterial Spin Labeling ◽

Bypass Surgery ◽

Spin Labeling ◽

High Flow ◽

Perfusion Magnetic Resonance Imaging ◽

Resonance Imaging

ABSTRACT OBJECTIVE: To prevent stroke after carotid sacrifice and to augment cerebral perfusion in patients with internal carotid artery (ICA) occlusion, high-flow extracranial-intracranial (EC-IC) bypass operations are performed. Although the function and efficacy of the bypass is monitored during surgery, the postoperative flow through the bypass is significantly lower than the flow in the contralateral ICA. Thus far, it is unknown whether decreased bypass flow is caused by a low tissue perfusion or by a relatively small flow territory. METHODS: Seven patients, four with an atherosclerotic ICA occlusion and three with a giant aneurysm of the ICA, were investigated; each underwent a high-flow EC-IC bypass and permanent occlusion of the ICA. Cerebral blood flow was measured with arterial spin labeling perfusion magnetic resonance imaging. Separate flow territory mapping of the EC-IC bypass, contralateral ICA, and posterior circulation was performed with selective arterial spin labeling magnetic resonance imaging. RESULTS: No significant difference was found in cerebral blood flow between the hemisphere ipsilateral to the EC-IC bypass (70.9 ± 11.3 ml/min/100 g tissue), contralateral to the EC-IC bypass (71.9 ± 14.3 ml/min/100 g tissue), and comparable findings in 50 healthy control participants (69.1 ± 17.5 ml/min/100 g tissue). Paired analysis of the individual flow territories demonstrated a 15% volume reduction (P = 0.018) in flow territory of the EC-IC bypass compared with the contralateral side. CONCLUSION: In the present study, we demonstrate the feasibility of selective arterial spin labeling magnetic resonance imaging for clinical follow-up of patients after high-flow EC/IC bypass surgery, providing both information on flow territories and the level of regional cerebral blood flow.

Download Full-text