scholarly journals The Structure and Function of Ionotropic Receptors in Drosophila

2021 ◽  
Vol 13 ◽  
Author(s):  
Lina Ni
Keyword(s):  
Glutamate Receptors ◽  
Structure And Function ◽  
Ionotropic Glutamate Receptors ◽  
Animal Kingdom ◽  
Ionotropic Receptors ◽  
Ir Studies ◽  
Major Branch ◽  
Future Direction ◽  
And Function ◽  
Peripheral Sensory

Ionotropic receptors (IRs) are a highly divergent subfamily of ionotropic glutamate receptors (iGluR) and are conserved across Protostomia, a major branch of the animal kingdom that encompasses both Ecdysozoa and Lophothrochozoa. They are broadly expressed in peripheral sensory systems, concentrated in sensory dendrites, and function in chemosensation, thermosensation, and hygrosensation. As iGluRs, four IR subunits form a functional ion channel to detect environmental stimuli. Most IR receptors comprise individual stimulus-specific tuning receptors and one or two broadly expressed coreceptors. This review summarizes the discoveries of the structure of IR complexes and the expression and function of each IR, as well as discusses the future direction for IR studies.

scholarly journals More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1753 ◽  
Author(s):  
Lena van Giesen ◽  
Paul A. Garrity
Keyword(s):  
Glutamate Receptors ◽  
Glutamate Receptor ◽  
Olfactory Receptors ◽  
Sensory Transduction ◽  
Ionotropic Glutamate Receptors ◽  
Ionotropic Glutamate Receptor ◽  
Ecological Significance ◽  
Ionotropic Receptors ◽  
Sensory Modalities ◽  
Receptor Family

The ionotropic receptors (IRs) are a branch of the ionotropic glutamate receptor family and serve as important mediators of sensory transduction in invertebrates. Recent work shows that, though initially studied as olfactory receptors, the IRs also mediate the detection of taste, temperature, and humidity. Here, we summarize recent insights into IR evolution and its potential ecological significance as well as recent advances in our understanding of how IRs contribute to diverse sensory modalities.

Endogenous ion channel complexes: the NMDA receptor

2011 ◽  
Vol 39 (3) ◽  
pp. 707-718 ◽  
Author(s):  
René A.W. Frank
Keyword(s):  
Nmda Receptor ◽  
Ion Channel ◽  
Present Article ◽  
Neuronal Excitability ◽  
Structure And Function ◽  
Current Understanding ◽  
Ionotropic Receptors ◽  
Receptor Complexes ◽  
Aspartate Receptor ◽  
And Function

Ionotropic receptors, including the NMDAR (N-methyl-D-aspartate receptor) mediate fast neurotransmission, neurodevelopment, neuronal excitability and learning. In the present article, the structure and function of the NMDAR is reviewed with the aim to condense our current understanding and highlight frontiers where important questions regarding the biology of this receptor remain unanswered. In the second part of the present review, new biochemical and genetic approaches for the investigation of ion channel receptor complexes will be discussed.

scholarly journals Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Zachary A Knecht ◽  
Ana F Silbering ◽  
Lina Ni ◽  
Mason Klein ◽  
Gonzalo Budelli ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Recent Work ◽  
Sensory Neurons ◽  
Behavioral Responses ◽  
Ionotropic Glutamate Receptors ◽  
Neuronal Responses ◽  
Common Component ◽  
Ionotropic Receptors ◽  
Dry Air ◽  
Discrete Population

Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection, recent work has implicated two family members, IR21a and IR25a, in thermosensation in Drosophila. Here we characterize one of the most evolutionarily deeply conserved receptors, IR93a, and show that it is co-expressed and functions with IR21a and IR25a to mediate physiological and behavioral responses to cool temperatures. IR93a is also co-expressed with IR25a and a distinct receptor, IR40a, in a discrete population of sensory neurons in the sacculus, a multi-chambered pocket within the antenna. We demonstrate that this combination of receptors is required for neuronal responses to dry air and behavioral discrimination of humidity differences. Our results identify IR93a as a common component of molecularly and cellularly distinct IR pathways important for thermosensation and hygrosensation in insects.

scholarly journals Distinct combinations of variant ionotropic glutamate 1 receptors mediate thermosensation and hygrosensation in Drosophila

2016 ◽  
Author(s):  
Zachary A. Knecht ◽  
Ana F. Silbering ◽  
Lina Ni ◽  
Mason Klein ◽  
Gonzalo Budelli ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Recent Work ◽  
Sensory Neurons ◽  
Behavioral Responses ◽  
Ionotropic Glutamate Receptors ◽  
Neuronal Responses ◽  
Common Component ◽  
Ionotropic Receptors ◽  
Dry Air ◽  
Discrete Population

AbstractIonotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection in insects, recent work has implicated two family members, IR21a and IR25a, in thermosensation in Drosophila. Here we characterize one of the most deeply conserved receptors, IR93a, and show that it is co-expressed and functions with IR21a and IR25a to mediate physiological and behavioral responses to cool temperatures. IR93a is also co-expressed with IR25a and a distinct receptor, IR40a, in a discrete population of sensory neurons in the sacculus, a multi-chambered pocket within the antenna. We demonstrate that this combination of receptors is important for neuronal responses to dry air and behavioral discrimination of humidity differences. Our results identify IR93a as a common component of molecularly and cellularly distinct IR pathways underlying thermosensation and hygrosensation in insects.

Biochemical studies of the structure and function of theN-methyl-D-aspartate subtype of glutamate receptors

1999 ◽  
Vol 19 (2) ◽  
pp. 151-179 ◽  
Author(s):  
Anthone W. Dunah ◽  
Robert P. Yasuda ◽  
Jianhong Luo ◽  
Yuehua Wang ◽  
Kate L. Prybylowski ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Structure And Function ◽  
Biochemical Studies ◽  
And Function
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