Rating of Physics Laboratory Resources Management in Tertiary Institutions: Implications for Teaching and Learning STEM Subjects

Physics, a major branch of science requires adequate implementation of its theoretical and practical components. The critical role played by the use of laboratory in realising this goal cannot be overemphasized hence, the need for proper management of laboratory resources. This study investigated the rating of physics laboratory resources management in tertiary institution and its implications for STEM subjects using student’s voice. The investigation adopted a descriptive-survey research design which comprised 596 students taking physics-related courses in six tertiary institutions in Ondo State. A questionnaire with 19 item statements was designed titled ‘Questionnaire on Physics Laboratory Resources Management’ (QPLRM) and used to collect data for this study. The data collected were analysed using mean scores and ranking. Inadequate funding to carry out managerial plans and lackadaisical attitude on the part of lecturers were rated highest to have hindered the proper management of physics laboratory resources for improving STEM subjects. The study concludes that adequate funding and improved positive attitude on the part of lecturers and support staff are important to guarantee proper teaching of STEM subjects. The study recommends that government through its agencies should provide more funds for the adequate implementation of STEM subjects.

AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the glycerol-3-phosphate pathway for the synthesis of phospholipids and triacylglycerols. AGPAT2 is the only AGPAT isoform whose loss-of-function mutations cause a severe form of human congenital generalized lipodystrophy. Paradoxically, AGPAT2 deficiency is known to dramatically increase the level of its product, PA. Here, we find that AGPAT2 deficiency impairs the biogenesis and growth of lipid droplets. We show that AGPAT2 deficiency compromises the stability of CDP-diacylglycerol (DAG) synthases (CDSs) and decreases CDS activity in both cell lines and mouse liver. Moreover, AGPAT2 and CDS1/2 can directly interact and form functional complexes, which promote the metabolism of PA along the CDP-DAG pathway of phospholipid synthesis. Our results provide key insights into the regulation of metabolic flux during lipid synthesis and suggest substrate channelling at a major branch point of the glycerol-3-phosphate pathway.

Interpretations of Probability

If you check the weather prediction on your phone, you might read that there is a 30 percent chance of rain at 4:00 in the afternoon. What does this mean? More precisely, what is the fraction 30/100 a measure of? Probability is a concept that is widespread both in everyday life and in science. Ordinary speakers of English utter and have some understanding of sentences such as “I will probably be late for the meeting,” or “it’s unlikely that Luxembourg will win the next World Cup.” Various sciences make explicit probabilistic claims: “the probability that a radium atom will decay in 1620 years is 0.5”; “the probability that a house mouse whose father is heterozygous for the t haplotype will inherit that trait is 0.9.” Other claims implicitly invoke probability: “the life expectancy of a child born in Japan today is 85.3 years.” Probability theory is also a major branch of mathematics, and it was given its modern formulation by Kolmogorov in 1933. Kolmogorov’s formalism presents a function P that satisfies a set of axioms: it is non-negative, normalized, and additive. These axioms entail a rich set of theorems concerning the behavior of P; together they make up the probability calculus. While the resulting theory is a formal theory in its own right, it is also natural to interpret P—to attach meanings, or truth conditions to claims involving it. ‘What is P?’, one may ask. This may be understood as a metaphysical question about what kinds of things are probabilities, or more generally as a question about what makes probability statements true or false. The various interpretations of probability attempt to answer this question, one way or another. This article surveys the literature on the interpretations of probability, due to mathematicians and especially philosophers. It divides the interpretations into two broad categories. Epistemological interpretations understand probability in terms of an agent’s beliefs, the strength of evidence in support of a statement, or other epistemological categories. Physical interpretations view probability as a feature of the world that would exist regardless of what evidence exists or what agents believe. This is a natural taxonomy, but others could be adopted, and its sub-categories are also somewhat pliable. The authors would like to thank Kim Border, Chris Bottomley, Kenny Easwaran, Hanti Lin, Charles Sebens, Glenn Shafer, Julia Staffel, Jeremy Strasser, and an anonymous referee for many helpful suggestions.

The Structure and Function of Ionotropic Receptors in Drosophila

Ionotropic receptors (IRs) are a highly divergent subfamily of ionotropic glutamate receptors (iGluR) and are conserved across Protostomia, a major branch of the animal kingdom that encompasses both Ecdysozoa and Lophothrochozoa. They are broadly expressed in peripheral sensory systems, concentrated in sensory dendrites, and function in chemosensation, thermosensation, and hygrosensation. As iGluRs, four IR subunits form a functional ion channel to detect environmental stimuli. Most IR receptors comprise individual stimulus-specific tuning receptors and one or two broadly expressed coreceptors. This review summarizes the discoveries of the structure of IR complexes and the expression and function of each IR, as well as discusses the future direction for IR studies.

“The Frog’s Courtship” and Other Sources

The stanzaic form of “The Frog’s Courtship” represents a second major branch in the lineage of the “Sweet Thing” scheme. Chapter 2 concerns its progress from Elizabethan England all the way to late nineteenth-century ragtime and early twentieth-century blues and country music. The stanzaic form appears in the United States by the early nineteenth century and then largely disappears from print until reemerging in several songs collected by folklorists in the early twentieth century, demonstrating its strong endurance in oral tradition. More often than “Captain Kidd,” this second stanzaic form appears in extensively abbreviated versions, reflecting its oral mode of transmission, which allows for more flexibility in length of bars. In early ragtime, the form unites with the harmonic language of contemporaneous popular music and acquires melodic and textual content that subsequently imbues early blues and country music as pervasive elements of the twentieth-century “Sweet Thing” scheme.

Water Quality Data Outlier Detection Method Based on Spatial Series Features

Outlier detection is one of the major branch in data mining which has been applied in different fields. Researchers have focused on the outlier detection in time series, but rarely spatial series. In this paper, we propose a new outlier detection method based on k-nearest neighbour (KNN) and Mahalanobis distance, which is first applied to the water field. Experimental results verify that the algorithm has good accuracy and effectiveness in outlier detection for water quality spatial series dataset.

Rho Family of Ras-Like GTPases in Early-Branching Animals

Non-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which function as key molecular switches that play important roles in converting and amplifying external signals into cellular responses. This review represents a compilation of the current knowledge on Rho-family GTPases in non-bilaterian animals, the available experimental data about their biochemical characteristics and functions, as well as original bioinformatics analysis, in order to gain a general insight into the evolutionary history of Rho-family GTPases in simple animals.

Enriched Meanings

This book presents a theory of enriched meanings for natural language interpretation. Certain expressions that exhibit complex effects at the semantics/pragmatics boundary live in an enriched meaning space while others live in a more basic meaning space. These basic meanings are mapped to enriched meanings just when required compositionally, which avoids generalizing meanings to the worst case. The theory is captured formally using monads, a concept from category theory. Monads are also prominent in functional programming and have been successfully used in the semantics of programming languages to characterize certain classes of computation. They are used here to model certain challenging linguistic computations at the semantics/pragmatics boundary. Part I presents some background on the semantics/pragmatics boundary, informally presents the theory of enriched meanings, reviews the linguistic phenomena of interest, and provides the necessary background on category theory and monads. Part II provides novel compositional analyses of the following phenomena: conventional implicature, substitution puzzles, and conjunction fallacies. Part III explores the prospects of combining monads, with particular reference to these three cases. The authors show that the compositional properties of monads model linguistic intuitions about these cases particularly well. The book is an interdisciplinary contribution to Cognitive Science: These phenomena cross not just the boundary between semantics and pragmatics, but also disciplinary boundaries between Linguistics, Philosophy and Psychology, three of the major branches of Cognitive Science, and are here analyzed with techniques that are prominent in Computer Science, a fourth major branch. A number of exercises are provided to aid understanding, as well as a set of computational tools (available at the book's website), which also allow readers to develop their own analyses of enriched meanings.

Clinical Impact of Hypofractionated Carbon Ion Radiotherapy on Locally Advanced Hepatocellular Carcinoma

Background: Hepatocellular carcinoma (HCC) involving a major branch of the portal or hepatic vein is in a locally advanced stage and remains difficult to cure. This study aimed to evaluate the clinical effects of carbon ion radiotherapy (C-ion RT) in locally advanced HCC (LAHCC). Methods: The data of 11 consecutive patients with LAHCC who received C-ion RT were analyzed. The C-ion RT doses of 52.8 Gy (relative biological effectiveness [RBE]) and 60.0 Gy (RBE) were delivered in 4 fractions for standard cases, and the 60.0 Gy dose was delivered in 12 fractions for close-to-gastrointestinal-tract cases. Survival and local control probabilities were calculated using the Kaplan-Meier method. Results: The median follow-up duration after C-ion RT was 36.4 months. The median age at the time of registration for C-ion RT was 76 years. The median tumor size was 53 mm. The numbers of treatment-naive and recurrent HCC patients were 1 and 10, respectively. Direct invasion of the major branch of the portal vein, hepatic vein, or both portal and hepatic veins was observed in three, five, and three patients, respectively. The 3-year overall survival, local control, and progression-free survival rates were 64%, 78%, and 18%, respectively. No patient developed radiation-induced liver diseases or grade 3 or higher toxicities in the acute and late phases. Conclusions: C-ion RT showed favorable clinical outcomes with a high rate of local control and minimal toxicities in LAHCC. Our findings suggest that C-ion RT is a promising multidisciplinary treatment option in LAHCC.

Recent advances in 2D, 3D and higher-order topological photonics

Over the past decade, topology has emerged as a major branch in broad areas of physics, from atomic lattices to condensed matter. In particular, topology has received significant attention in photonics because light waves can serve as a platform to investigate nontrivial bulk and edge physics with the aid of carefully engineered photonic crystals and metamaterials. Simultaneously, photonics provides enriched physics that arises from spin-1 vectorial electromagnetic fields. Here, we review recent progress in the growing field of topological photonics in three parts. The first part is dedicated to the basics of topological band theory and introduces various two-dimensional topological phases. The second part reviews three-dimensional topological phases and numerous approaches to achieve them in photonics. Last, we present recently emerging fields in topological photonics that have not yet been reviewed. This part includes topological degeneracies in nonzero dimensions, unidirectional Maxwellian spin waves, higher-order photonic topological phases, and stacking of photonic crystals to attain layer pseudospin. In addition to the various approaches for realizing photonic topological phases, we also discuss the interaction between light and topological matter and the efforts towards practical applications of topological photonics.