Vitamin D and Acute Kidney Injury: A Two-Way Causality Relation and a Predictive, Prognostic, and Therapeutic Role of Vitamin D

Background: Acute kidney injury (AKI) constitutes a multi-factorially caused condition, which significantly affects kidney function and can lead to elevated risk of morbidity and mortality. Given the rising scientific evidence regarding vitamin D's (VitD's) multisystemic role, the connection between AKI and VitD is currently being studied, and the complex relation between them has started to be unraveled.Methods: A systematic review had been conducted to identify the pathogenetic relation of VitD and AKI and the potential role of VitD as a biomarker and therapeutic–renoprotective factor.Results: From 792 articles, 74 articles were identified that fulfilled the inclusion criteria. Based on these articles, it has been found that not only can VitD disorders (VitD deficiency or toxicity) cause AKI but, also, AKI can lead to great disruption in the metabolism of VitD. Moreover, it has been found that VitD serves as a novel biomarker for prediction of the risk of developing AKI and for the prognosis of AKI's severity. Finally, animal models showed that VitD can both ameliorate AKI and prevent its onset, suggesting its renoprotective effect.Conclusion: There is a complex two-way pathogenetic relation between VitD disorders and AKI, while, concomitantly, VitD serves as a potential novel predictive–prognostic biomarker and a treatment agent in AKI therapy.

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Acute kidney injury following acute liver failure: potential role of systemic cadmium mobilization?

Intensive Care Medicine ◽

10.1007/s00134-011-2449-0 ◽

2012 ◽

Vol 38 (3) ◽

pp. 467-473 ◽

Cited By ~ 11

Author(s):

Perrine Hoet ◽

Vincent Haufroid ◽

Gladys Deumer ◽

Xavier Dumont ◽

Dominique Lison ◽

...

Keyword(s):

Acute Kidney Injury ◽

Liver Failure ◽

Acute Liver Failure ◽

Potential Role ◽

Kidney Injury

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Prevention of acute kidney injury

10.1093/med/9780199592548.003.0226_update_001 ◽

2018 ◽

Author(s):

Norbert Lameire

Keyword(s):

Acute Kidney Injury ◽

Cardiac Surgery ◽

Growth Factor ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Potential Role ◽

Kidney Injury ◽

Pharmacological Interventions ◽

Selection Of

This chapter summarizes the pharmacological interventions that can be used in the prevention of acute kidney injury (AKI). These following interventions are discussed: the use and selection of vasopressors; the administration of loop diuretics and mannitol; vasodilating drugs including dopamine, atrial natriuretic peptide, nesiritide, fenoldopam, and adenosine antagonists. The role of N-acetylcysteine in the prevention of contrast-induced AKI and cardiac surgery is discussed. The chapter concludes with a summary of the potential role of insulin-like growth factor and erythropoietin in the prevention of AKI.

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Vitamin D/VDR in acute kidney injury: a potential therapeutic target

Current Medicinal Chemistry ◽

10.2174/0929867327666201118155625 ◽

2020 ◽

Vol 27 ◽

Author(s):

Siqing Jiang ◽

Lihua Huang ◽

Wei Zhang ◽

Hao Zhang

Keyword(s):

Vitamin D ◽

Acute Kidney Injury ◽

Therapeutic Target ◽

Poor Prognosis ◽

Therapeutic Potential ◽

Kidney Injury ◽

Potential Therapeutic Target ◽

Promising Therapeutic Target ◽

Incidence And Mortality

: Despite many strategies and parameters used in clinical practice, the incidence and mortality of acute kidney injury (AKI) are still high with poor prognosis. With the development of molecular biology, the role of vitamin D and vitamin D receptor (VDR) in AKI is drawing increasing attention. Accumulated researches have suggested that Vitamin D deficiency is a risk factor of both clinical and experimental AKI, and vitamin D/VDR could be a promising therapeutic target against AKI. However, more qualitative clinical researches are needed to provide stronger evidence for clinical application of vitamin D and VDR agonists in the future. Issues like the route and dosage of administration also await more attention. The present review aims to summarize the current works on the role of vitamin D/VDR in AKI and try to provide some new insight of its therapeutic potential.

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