Saccharina japonica Ethanol Extract Ameliorates Depression/Anxiety-Like Behavior by Inhibiting Inflammation, Oxidative Stress, and Apoptosis in Dextran Sodium Sulfate Induced Ulcerative Colitis Mice

Saccharina japonica is a common marine vegetable in East Asian markets and has a variety of health benefits. This study was focused on the anti-depressant/anxiety effects of Saccharina japonica ethanol extract (SJE) on dextran sodium sulfate (DSS)-induced mice and its potential mechanism in their brain. Male C57BL/6 mice were treated with mesalazine and various doses of SJE (1, 2, and 4 g/kg body weight) for 2 weeks, followed by DSS treatment at the second week. The DSS-induced mice showed depression/anxiety-like behavior, which included shorter path length in the open field test and longer immobility time in the tail suspension test. L-SJE alleviated the depression-like behaviors. In the DSS-induced mice, reduced synaptic plasticity activated microglia, increased proinflammatory cytokines, decreased anti-inflammatory cytokine, and increased expression levels of Toll-like receptors-4, nuclear factor kappa-B, NOD-like receptors 3, apoptosis-associated speck-like protein, and Caspase-1 were observed, most of which were alleviated by SJE treatment. Furthermore, all the SJE groups could significantly enhance superoxide dismutase activity, while the L-SJE treatment decreased the contents of malondialdehyde, and the H-SJE treatment inhibited apoptosis. All these results showed that the SJE might serve as a nutritional agent for protecting the brain in ulcerative colitis mice.

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Ethanol Extract ofCordyceps militarisGrown on Germinated Soybeans Attenuates Dextran-Sodium-Sulfate- (DSS-) Induced Colitis by Suppressing the Expression of Matrix Metalloproteinases and Inflammatory Mediators

BioMed Research International ◽

10.1155/2013/102918 ◽

2013 ◽

Vol 2013 ◽

pp. 1-10 ◽

Cited By ~ 11

Author(s):

Dong Ki Park ◽

Hye-Jin Park

Keyword(s):

Matrix Metalloproteinases ◽

Inflammatory Mediators ◽

Sodium Sulfate ◽

Activity Index ◽

Disease Activity Index ◽

Ethanol Extract ◽

Treated Group ◽

Dextran Sodium Sulfate ◽

Protective Agent ◽

Colon Tissue

The effect ofCordyceps militaris(CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC significantly suppressed DSS-induced disease activity index (DAI) as well as histopathological scores, compared to control or CM-treated group. To elucidate the anti-IBD activity of GSC, we checked the level of matrix metalloproteinases (MMPs) and inflammatory mediators. GSC extract decreased the level of MMP-3 and -9 mRNAs and p53 proteins. The level and activity of LPS-induced MMP-9 were reduced in GSC-treated RAW264.7 cells. It also attenuated the level of inducible nitric oxide synthase (iNOS) and tumor necrosis factor- (TNF-)αmRNAs both in colon tissue and in macrophage cells. These results suggest that GSC can be applied as a protective agent against IBDs.

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Intrarectally administered polaprezinc attenuates the development of dextran sodium sulfate‑induced ulcerative colitis in mice

Experimental and Therapeutic Medicine ◽

10.3892/etm.2019.8155 ◽

2019 ◽

Author(s):

Zhaoyang Liu ◽

Wenbo Xie ◽

Mingru Li ◽

Jing Liu ◽

Xiao Liang ◽

...

Keyword(s):

Ulcerative Colitis ◽

Sodium Sulfate ◽

Dextran Sodium Sulfate

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The Role of SPARC in Human Ulcerative Colitis and Murine Dextran Sodium Sulfate-Induced Colitis

Gastroenterology ◽

10.1016/s0016-5085(11)63473-2 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-837

Author(s):

Tomohisa Takagi ◽

Yuji Naito ◽

Wataru Aoi ◽

Ryusuke Horie ◽

Kazuhiko Uchiyama ◽

...

Keyword(s):

Ulcerative Colitis ◽

Sodium Sulfate ◽

Dextran Sodium Sulfate

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Licoflavone B, an isoprene flavonoid derived from licorice residue, relieves dextran sodium sulfate-induced ulcerative colitis by rebuilding the gut barrier and regulating intestinal microflora

European Journal of Pharmacology ◽

10.1016/j.ejphar.2021.174730 ◽

2021 ◽

pp. 174730

Author(s):

Juan Zhang ◽

Xiaoqin Xu ◽

Ning Li ◽

Li Cao ◽

Yu Sun ◽

...

Keyword(s):

Ulcerative Colitis ◽

Sodium Sulfate ◽

Intestinal Microflora ◽

Dextran Sodium Sulfate ◽

Gut Barrier

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Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice

Scientific Reports ◽

10.1038/s41598-020-75702-5 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Shashank Singh ◽

Ruchika Bhatia ◽

Pragyanshu Khare ◽

Shikha Sharma ◽

Sivasubramanian Rajarammohan ◽

...

Keyword(s):

Ulcerative Colitis ◽

Sodium Sulfate ◽

Activity Index ◽

Disease Activity Index ◽

Dextran Sodium Sulfate ◽

Raw 264.7 Cells ◽

Spleen Weight ◽

Lipocalin 2 ◽

Weight Percentage ◽

Microbial Dysbiosis

Abstract Crohn’s and ulcerative colitis are common inflammatory conditions associated with Inflammatory bowel disease. Owing to the importance of diet based approaches for the prevention of inflammatory gut conditions, the present study was aimed to screen the human isolates of Bifidobacterium strains based on their ability to reduce LPS-induced inflammation in murine macrophage (RAW 264.7) cells and to evaluate prioritized strains for their preventive efficacy against ulcerative colitis in mice. Twelve out of 25 isolated strains reduced the production of LPS-induced nitric oxide and inflammatory cytokines. Furthermore, three strains, B. longum Bif10, B. breve Bif11, and B. longum Bif16 conferred protection against dextran sodium sulfate induced colitis in mice. The three strains prevented shortening of colon, spleen weight, percentage body weight change and disease activity index relative to colitis mice. Lower levels of Lipocalin-2, TNF-α, IL-1β and IL-6 and improved SCFA levels were observed in Bifidobacterium supplemented mice relative to DSS counterparts. Bacterial composition of B. longum Bif10 and B. breve Bif11 fed mice was partly similar to the normal mice, while DSS and B. longum Bif16 supplemented mice showed deleterious alterations. At the genus level, Bifidobacterium supplementation inhibited the abundances of pathobionts such as Haemophilus, Klebsiella and Lachnospira there by conferring protection.

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Therapeutic Effects of Ecabet Sodium, an Antiulcer Drug, on Dextran Sodium Sulfate–Induced Ulcerative Colitis in Rats

Digestive Diseases and Sciences ◽

10.1007/s10620-005-2665-y ◽

2005 ◽

Vol 50 (5) ◽

pp. 922-927 ◽

Cited By ~ 7

Author(s):

Tsunehisa Noto ◽

Hiroshi Yamada ◽

Takashi Inui ◽

Kayoko Okuyama ◽

Ayako Watanable ◽

...

Keyword(s):

Ulcerative Colitis ◽

Sodium Sulfate ◽

Dextran Sodium Sulfate ◽

Therapeutic Effects ◽

Antiulcer Drug ◽

Ecabet Sodium

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Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests

Chinese Medicine ◽

10.1186/s13020-019-0254-9 ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 1

Author(s):

Ming Zhong ◽

Xiaoting Tian ◽

Shuoji Chen ◽

Mingcang Chen ◽

Ziqiong Guo ◽

...

Keyword(s):

Oral Administration ◽

Tail Suspension Test ◽

Active Components ◽

Evaluation Standards ◽

Hepatic Disposition ◽

Antidepressant Effects ◽

Immobility Time ◽

Quantitative Analyses ◽

Swimming Test ◽

The Brain

Abstract Background Modern pharmacological studies have demonstrated that Baihe–Zhimu decoction (BZD) has antidepressant effects. However, the complex composition and lack of clear evaluation standards for BZD make it less likely to be understood and accepted than evidence-based active natural compounds. Methods In this study, an effective method for the identification of antidepressant components was demonstrated and applied to BZD. The first step was to evaluate the efficacy of BZD by the forced swimming test (FST) and the tail suspension test (TST), followed by successive quantitative analyses of the absorbed constituents at different stages, such as before hepatic disposition, liver distribution, after hepatic disposition and brain distribution after the oral administration of BZD. Finally, the compounds detected in the brain were confirmed by activity testing. Results Our investigation observed that timosaponin BII and timosaponin BIII were accurately determined in the brain after oral administration of BZD, and they were further confirmed to reduce the immobility time in the FST and TST. As described above, timosaponin BII and timosaponin BIII were used to scientifically and reasonably explain the effective chemical basis of the effect of BZD on depression. Conclusions This research affords an effective method to discover lead molecules for antidepressants from traditional Chinese medicine.

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Effects of a β-type glycosidic polysaccharide from Flammulina velutipes on anti-inflammation and gut microbiota modulation in colitis mice

Food & Function ◽

10.1039/c9fo03017d ◽

2020 ◽

Vol 11 (5) ◽

pp. 4259-4274

Author(s):

Ruiqiu Zhao ◽

Yang Ji ◽

Xin Chen ◽

Anxiang Su ◽

Gaoxing Ma ◽

...

Keyword(s):

Ulcerative Colitis ◽

Gut Microbiota ◽

Sodium Sulfate ◽

Dextran Sodium Sulfate ◽

Flammulina Velutipes ◽

Anti Inflammation

Using the Flammulina velutipes polysaccharide (FVP) extracted from our previous study, herein, we investigated the improvement of this β-type glycosidic polysaccharide in alleviating dextran sodium sulfate-induced ulcerative colitis (UC) in mice.

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