scholarly journals Comprehensive Analysis of ATP6V1s Family Members in Renal Clear Cell Carcinoma With Prognostic Values

2020 ◽  
Vol 10 ◽  
Author(s):  
Xiaojuan Li ◽  
Hao Li ◽  
Caihong Yang ◽  
Liu Liu ◽  
Sisi Deng ◽  
...  
2021 ◽  
Author(s):  
Jun Qian ◽  
Bizhi Tu ◽  
Yaya Jia ◽  
Laifu Wei ◽  
Fei Gao ◽  
...  

Abstract Background COL4A family genes are a group of genes related to the extracellular matrix, which have been proven to be associated with various cancers. However, its relationship with kidney renal clear cell carcinoma (KIRC) has not been reported. Methods Hence, we obtained the data of differential expression and survival time of COL4A genes in KIRC from an online open-access database including ONCOMINE, UALCAN, GEPIA, Cancer Genome Atlas (TCGA) database, cBioPortal, Metascape, and STRING. Results We found significant overexpression in COL4A1, COL4A2 while COL4A 3, COL4A4, COL4A5, and COL4A6 has decreased in tumor tissues. Moreover, almost all COL4A family genes obviously correlated with individual cancer stages of KIRC; and higher expression of COL4A1/2/3/BP/4 was found to accompany better overall survival time (OS) while COL4A5 with a lower OS in KIRC patients. We also found that the COL4A genes altered group had longer OS and DFS than unaltered teams.


2020 ◽  
Vol 9 (22) ◽  
pp. 8624-8638 ◽  
Author(s):  
Shitong Lin ◽  
Lingling Zheng ◽  
Yuchao Lu ◽  
Qidong Xia ◽  
Peng Zhou ◽  
...  

2012 ◽  
Vol 107 (5) ◽  
pp. 856-863 ◽  
Author(s):  
T Qayyum ◽  
P A McArdle ◽  
G W Lamb ◽  
F Jordan ◽  
C Orange ◽  
...  

2013 ◽  
Vol 13 (2) ◽  
pp. 79-80
Author(s):  
Zane Simtniece ◽  
Gatis Kirsakmens ◽  
Ilze Strumfa ◽  
Andrejs Vanags ◽  
Maris Pavars ◽  
...  

Abstract Here, we report surgical treatment of a patient presenting with pancreatic metastasis (MTS) of renal clear cell carcinoma (RCC) 11 years after nephrectomy. RCC is one of few cancers that metastasise in pancreas. Jaundice, abdominal pain or gastrointestinal bleeding can develop; however, asymptomatic MTS can be discovered by follow-up after removal of the primary tumour. The patient, 67-year-old female was radiologically diagnosed with a clinically silent mass in the pancreatic body and underwent distal pancreatic resection. The postoperative period was smooth. Four months after the surgery, there were no signs of disease progression.


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