scholarly journals Procedural Pain Assessment in Infants Without Analgosedation: Comparison of Newborn Infant Parasympathetic Evaluation and Skin Conductance Activity - A Pilot Study

2022 ◽  
Vol 9 ◽  
Author(s):  
Wojciech Walas ◽  
Zenon P. Halaba ◽  
Tomasz Szczapa ◽  
Julita Latka-Grot ◽  
Iwona Maroszyńska ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Newborn Infant ◽  
Skin Conductance ◽  
Pain Assessment ◽  
New Technologies ◽  
Procedural Pain ◽  
Pain Scales ◽  
Scale Scores ◽  
Newborn Infant Parasympathetic Evaluation

Objective: New technologies to measure pain responses, such as heart rate variability and skin conductance hold promise in the development of tools that can be reliable and quantifiable of detecting pain. The main objective of this study was to assess the capability of two monitors i.e., Newborn Infant Parasympathetic Evaluation (NIPE) and Skin Conductance Algesimeter for detecting procedural pain in non-anesthetized infants.Materials and Methods: Thirty-three non-anesthetized infants were enrolled to the study. To detect pain caused by heel stick, NIPE, and Skin Conductance monitors and behavioral pain scales were used. Three minutes before and just after heel stick, pain was evaluated by behavioral scales, and simultaneously over the whole period by NIPE and SCA.Results: A statistically significant decrease of NIPE Index and an increase of SCA values were found after the HS procedure. There were no statistically significant differences between the decrease in NIPEi values and the increase in PPS values between subgroups based on pain assessment by behavioral-scale scores.Conclusion: Both NIPE and SCA can be useful for detection of procedural pain and may constitue an additional valuable tool for better handling of pain among patients treated in NICUs. More studies on larger groups of patients are needed.

The newborn infant parasympathetic evaluation index for acute procedural pain assessment in preterm infants

2020 ◽  
Author(s):  
Julie Gendras ◽  
Pauline Lavenant ◽  
Iona Sicard-Cras ◽  
Maëlys Consigny ◽  
Laurent Misery ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Newborn Infant ◽  
Pain Assessment ◽  
Evaluation Index ◽  
Procedural Pain ◽  
Newborn Infant Parasympathetic Evaluation

Newborn Infant Parasympathetic Evaluation Index for the Assessment of Procedural Pain in Nonanesthetized Infants: A Multicenter Pilot Study

2020 ◽  
Author(s):  
Wojciech Walas ◽  
Julita Latka-Grot ◽  
Iwona Maroszyńska ◽  
Ewelina Malinowska ◽  
Magdalena Rutkowska ◽  
...  
Keyword(s):  
Newborn Infant ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Pediatric Intensive Care ◽  
Procedural Pain ◽  
Pain Scales ◽  
Group A ◽  
Noxious Stimuli ◽  
Nonverbal Children ◽  
Newborn Infant Parasympathetic Evaluation

Abstract Objective The aim of this study is to evaluate the ability of the Newborn Infant Parasympathetic Evaluation (NIPE) index to detect the response to nociceptive stimuli in nonanesthetized infants and to compare these results to simultaneous scoring by behavioral scales. Study Design Thirty-six nonanesthetized infants admitted to neonatal/pediatric intensive care unit (N/PICUs) were enrolled to the study. Due to faulty records of the data, three patients had to be excluded. To detect pain caused by noxious stimuli, the heart-rate-variability-derived NIPE index and behavioral pain scales designed for measuring procedural pain in nonverbal children were used. Results Forty-one painful events were available for analysis. We observed in the whole group a statistically significant decrease in NIPE values at 1, 2, and 3 minutes after a painful stimulus, in comparison to the NIPE value at rest and the statistically significant differences between the minimum NIPE value within 3 minutes after the stimulus in comparison to NIPE value at rest in the whole group, as well as in the subgroups of moderate and severe pain. Receiver operating characteristic (ROC) analysis has shown the strong sensitivity and specificity of the NIPE in detecting the noxious stimuli (ROC AUC: 0.767). We also found that the stronger the sensation of pain was, the more rapidly NIPE reached its lowest value. Discussion Our study indicates that the painful procedures are associated with a significant decrease in the NIPE value within 3 minutes after a noxious stimulus. Based on our observation, the minimum value within 3 minutes from the painful procedure seems to be the most distinctive value.

Newborn Infant Pain Assessment Using Heart Rate Variability Analysis

2010 ◽  
Vol 26 (9) ◽  
pp. 777-782 ◽  
Author(s):  
Papa M. Faye ◽  
Julien De Jonckheere ◽  
Regis Logier ◽  
Eliane Kuissi ◽  
Mathieu Jeanne ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Newborn Infant ◽  
Pain Assessment ◽  
Heart Rate Variability Analysis ◽  
Variability Analysis ◽  
Infant Pain

scholarly journals Stress Markers for Mental States and Biotypes of Depression and Anxiety: A Scoping Review and Preliminary Illustrative Analysis

2021 ◽  
Vol 5 ◽  
pp. 247054702110003
Author(s):  
Megan Chesnut ◽  
Sahar Harati ◽  
Pablo Paredes ◽  
Yasser Khan ◽  
Amir Foudeh ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Skin Conductance ◽  
Neural Circuit ◽  
Current Knowledge ◽  
Mental States ◽  
Classification Model ◽  
Depression And Anxiety ◽  
Stress Markers ◽  
Physiological Markers

Depression and anxiety disrupt daily function and their effects can be long-lasting and devastating, yet there are no established physiological indicators that can be used to predict onset, diagnose, or target treatments. In this review, we conceptualize depression and anxiety as maladaptive responses to repetitive stress. We provide an overview of the role of chronic stress in depression and anxiety and a review of current knowledge on objective stress indicators of depression and anxiety. We focused on cortisol, heart rate variability and skin conductance that have been well studied in depression and anxiety and implicated in clinical emotional states. A targeted PubMed search was undertaken prioritizing meta-analyses that have linked depression and anxiety to cortisol, heart rate variability and skin conductance. Consistent findings include reduced heart rate variability across depression and anxiety, reduced tonic and phasic skin conductance in depression, and elevated cortisol at different times of day and across the day in depression. We then provide a brief overview of neural circuit disruptions that characterize particular types of depression and anxiety. We also include an illustrative analysis using predictive models to determine how stress markers contribute to specific subgroups of symptoms and how neural circuits add meaningfully to this prediction. For this, we implemented a tree-based multi-class classification model with physiological markers of heart rate variability as predictors and four symptom subtypes, including normative mood, as target variables. We achieved 40% accuracy on the validation set. We then added the neural circuit measures into our predictor set to identify the combination of neural circuit dysfunctions and physiological markers that accurately predict each symptom subtype. Achieving 54% accuracy suggested a strong relationship between those neural-physiological predictors and the mental states that characterize each subtype. Further work to elucidate the complex relationships between physiological markers, neural circuit dysfunction and resulting symptoms would advance our understanding of the pathophysiological pathways underlying depression and anxiety.

Human Psychophysiology and PTSD

2016 ◽  
Author(s):  
Tanja Jovanovic ◽  
Seth Davin Norrholm
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Clinical Research ◽  
Fear Conditioning ◽  
Skin Conductance ◽  
Symptom Severity ◽  
Muscle Contractions ◽  
Pavlovian Fear Conditioning ◽  
Psychophysiological Measures ◽  
Biological Assessments

Psychophysiological measures provide useful tools for investigating neurobiological mechanisms of trauma-related sequalae. In addition, they can serve as objective biological assessments of symptom severity in clinical research. This chapter describes the methods for collection of psychophysiological measures. These include muscle contractions (startle), electrodermal skin conductance, heart rate, and heart rate variability (HRV) at baseline, under stress, and following Pavlovian fear conditioning. These approaches are important both for understanding biology as well as for providing objective biomarkers that can be compared translationally from animals to humans. It also reviews the literature that has used these measures in PTSD. The evidence to date strongly suggests that these data provide robust correlates of PTSD severity.

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