scholarly journals The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia

2020 ◽  
Vol 11 ◽  
Author(s):  
Pia M. Vidal ◽  
Rodrigo Pacheco
Keyword(s):  
2018 ◽  
Vol 215 (11) ◽  
pp. 2702-2704 ◽  
Author(s):  
Aleksandra Deczkowska ◽  
Michal Schwartz

Immune cells patrol the brain and can support its function, but can we modulate brain–immune communication to fight neurological diseases? Here, we briefly discuss the mechanisms orchestrating the cross-talk between the brain and the immune system and describe how targeting this interaction in a well-controlled manner could be developed as a universal therapeutic approach to treat neurodegeneration.


2014 ◽  
Vol 30 ◽  
pp. 54-62 ◽  
Author(s):  
Hagit Shapiro ◽  
Christoph A Thaiss ◽  
Maayan Levy ◽  
Eran Elinav

2020 ◽  
Vol 11 ◽  
Author(s):  
D. R. Rodrigues ◽  
K. M. Wilson ◽  
M. Trombetta ◽  
W. N. Briggs ◽  
A. F. Duff ◽  
...  

2019 ◽  
Vol 21 (1) ◽  
pp. 21-25 ◽  

Emerging results support the concept that Alzheimer disease (AD) and age-related dementia are affected by the ability of the immune system to contain the brain's pathology. Accordingly, well-controlled boosting, rather than suppression of systemic immunity, has been suggested as a new approach to modify disease pathology without directly targeting any of the brain's disease hallmarks. Here, we provide a short review of the mechanisms orchestrating the cross-talk between the brain and the immune system. We then discuss how immune checkpoint blockade directed against the PD-1/PD-L1 pathways could be developed as an immunotherapeutic approach to combat this disease using a regimen that will address the needs to combat AD.


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