scholarly journals A Promising Anticancer Agent Dimethoxycurcumin: Aspects of Pharmacokinetics, Efficacy, Mechanism, and Nanoformulation for Drug Delivery

2021 ◽  
Vol 12 ◽  
Author(s):  
Muhammad Sohail ◽  
Wenna Guo ◽  
Xin Yang ◽  
Zhiyong Li ◽  
Yanli Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Natural Product ◽  
Anticancer Agent ◽  
Metabolic Stability ◽  
Effective Drug ◽  
Original Research ◽  
Research Groups ◽  
Lipophilic Compound ◽  
Poor Solubility ◽  
Adme Properties

Curcumin is a well-known anticancer natural product with various significant bioactivities that has been well documented, but its widespread use is mainly hindered by insufficient ADME properties such as poor solubility and low metabolic stability. Dimethoxycurcumin (DiMC) is a kind of lipophilic compound derived from curcumin that maintains its anticancer potency and has greatly improved systematic bioavailability. Therefore, DiMC is regarded as a promising plant-derived anticancer agent that deserves to be well developed. Herein, we concentrate on the published work by those from original research groups concerned with the pharmacokinetics, efficacy, and mechanism of DiMC involved in the treatment of various tumors, as well as the nanoformulations for effective drug delivery.

scholarly journals Porous discoidal polymeric particles for effective drug delivery minimizing phagocytosis

2021 ◽  
Vol 49 (1) ◽  
pp. 390-396
Author(s):  
Susmita Aryal ◽  
Sanghyo Park ◽  
Chaewon Park ◽  
Moon Jung Choi ◽  
Jaehong Key
Keyword(s):  
Drug Delivery ◽  
Effective Drug ◽  
Polymeric Particles

Dual pH-responsive micelles with both charge-conversional property and hydrophobic–hydrophilic transition for effective cellular uptake and intracellular drug release

2016 ◽  
Vol 7 (12) ◽  
pp. 2202-2208 ◽  
Author(s):  
Shuai Li ◽  
Zhouxiang Zhao ◽  
Wei Wu ◽  
Chunmei Ding ◽  
Jianshu Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Uptake ◽  
Diblock Copolymers ◽  
Effective Drug ◽  
Ph Responsive ◽  
A Charge

Two types of diblock copolymers are synthesized to construct dual pH-responsive micelles with a charge-conversional property for effective drug delivery.

scholarly journals Micro-needles as an effective drug delivery system and associated patents in pharmaceutical field: A Review

2022 ◽  
Vol 01 (01) ◽  
pp. 53-66
Author(s):  
Sumel Ashique ◽  
Vaibhavi mittal ◽  
Tahamina Khatun ◽  
Aakash Upadhyay ◽  
Suryakant Verma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug

scholarly journals What Is the Most Effective Drug Delivery System for Cisplatin during the Treatment of Hepatic Tumors with Single-Session Transcatheter Chemotherapy? A Pilot Study

Gut and Liver ◽  
2013 ◽  
Vol 7 (5) ◽  
pp. 576-584 ◽  
Author(s):  
Yusuke Kawamura ◽  
Kenji Ikeda ◽  
Taito Fukushima ◽  
Yuya Seko ◽  
Tasuku Hara ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pilot Study ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug ◽  
Hepatic Tumors ◽  
Single Session

scholarly journals A REVIEW: ANTI-CANCER NATURAL PRODUCT DRUG DELIVERY SYSTEM DOSAGE FORM AND EVALUATION

2021 ◽  
pp. 41-51
Author(s):  
RIZKA KHOIRUNNISA GUNTINA ◽  
IYAN SOPYAN ◽  
ADE ZUHROTUN
Keyword(s):  
Drug Delivery ◽  
Natural Product ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Dosage Forms ◽  
Primary Data ◽  
Pharmaceutical Dosage Form ◽  
New Drug

A drug delivery system is a system in which a drug is released from a pharmaceutical dosage form to achieve the desired pharmacological effect. The system consists of conventional and new drug delivery systems. In the new drug delivery system, polymers are used as a matrix. The aim of this article is to find out and understand the formulation and evaluation of natural ingredients that have anticancer activity with different dosage forms and the basis for developing these dosages. Journal searches in this review came from primary data sources on the internet. Journal searches were carried out using a search engine such as Google Scholar, PubMed, and ScienceDirect. In recent years, natural products, such as extract, fraction, and isolate, are getting attention to help treat cancer. Because of their low solubility and bioavailability, the effectiveness tends to be lower than synthetic drugs. Therefore, a dosage form with a new drug delivery system was made to overcome the problem. The dosage forms commonly made are patch, suspension, powder, and emulsion with a new drug delivery system. To ensure the product that has been made met the requirements, they need to be evaluated with various methods like In vitro Study, morphology study, particle size study, and others. Cancer treatment using the natural product can be delivered through several dosage forms like patch, suspension, powder, and emulsion, with specific formulation and manufacturing methods based on several considerations such as natural ingredients properties, dosage form selection, excipient properties, and the purpose of the formulation. Dosage forms that has been made are then evaluated using several evaluation methods.

LECITHINIZED SUPEROXIDE DISMUTASE -AN EFFECTIVE DRUG DELIVERY SYSTEM-

1994 ◽  
pp. 314-315
Author(s):  
R. IGARASHI ◽  
J. HOSHINO ◽  
M. TAKENAGA ◽  
S. KAWAI ◽  
Y. MORIZAWA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Superoxide Dismutase ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug
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