scholarly journals Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study

2018 ◽  
Vol 9 ◽  
Author(s):  
Laura L. Perissinotti ◽  
Pablo M. De Biase ◽  
Jiqing Guo ◽  
Pei-Chi Yang ◽  
Miranda C. Lee ◽  
...  
Keyword(s):  
Simulation Study ◽  
Gating Kinetics ◽  
Kinetics Of ◽  
Herg1 Channel

The Gating Kinetics of the Slow Vacuolar Channel. A Novel Mechanism for SV Channel Functioning?

2003 ◽  
Vol 194 (1) ◽  
pp. 11-20 ◽  
Author(s):  
H. Miedema ◽  
A. H. de Boer ◽  
O. Pantoja
Keyword(s):  
Gating Kinetics ◽  
Slow Vacuolar Channel ◽  
Kinetics Of ◽  
Sv Channel

Gating Kinetics of Stochastic Single K Channels

1981 ◽  
pp. 123-132 ◽  
Author(s):  
Jürgen F. Fohlmeister ◽  
William J. Adelman
Keyword(s):  
K Channels ◽  
Gating Kinetics ◽  
Kinetics Of

scholarly journals Modeling of the adsorption kinetics of zinc onto granular activated carbon and natural zeolite

2006 ◽  
Vol 71 (8-9) ◽  
pp. 957-967 ◽  
Author(s):  
Ljiljana Markovska ◽  
Vera Meshko ◽  
Mirko Marinkovski
Keyword(s):  
Mass Transfer ◽  
Activated Carbon ◽  
Simulation Study ◽  
Natural Zeolite ◽  
Granular Activated Carbon ◽  
Model Parameters ◽  
Mass Transfer Resistance ◽  
External Mass Transfer ◽  
Transfer Resistance ◽  
Kinetics Of

The isotherms and kinetics of zinc adsorption from aqueous solution onto granular activated carbon (GAC) and natural zeolite were studied using an agitated batch adsorber. The maximum adsorption capacities of GAC and natural zeolite towards zinc(II) from Langmuir adsorption isotherms were determined using experimental adsorption equilibrium data. The homogeneous solid diffusion model (HSD-model) combined with external mass transfer resistance was applied to fit the experimental kinetic data. The kinetics simulation study was performed using a computer program based on the proposed mathematical model and developed using gPROMS. As the two-mass transfer resistance approach was applied, two model parameters were fitted during the simulation study. External mass transfer and solid phase diffusion coefficients were obtained to predict the kinetic curves for varying initial Zn(II) concentration at constant agitation speed and constant adsorbent mass. For any particular Zn(II) - adsorbent system, k f was constant, except for the lowest initial concentration, while D s was found to increase with increasing initial Zn(II) concentration.

Modified Hodgkin-Huxley gating kinetics of sodium activation in giant axons of squid (Doryteuthis bleekeri)

1985 ◽  
Vol 112 (4) ◽  
pp. 695-705 ◽  
Author(s):  
Gen Matsumoto ◽  
Masashi Urayama ◽  
Michinori Ichikawa
Keyword(s):  
Giant Axons ◽  
Gating Kinetics ◽  
Sodium Activation ◽  
Kinetics Of

scholarly journals RGS proteins reconstitute the rapid gating kinetics of G  -activated inwardly rectifying K+ channels

1997 ◽  
Vol 94 (19) ◽  
pp. 10461-10466 ◽  
Author(s):  
C. A. Doupnik ◽  
N. Davidson ◽  
H. A. Lester ◽  
P. Kofuji
Keyword(s):  
Rgs Proteins ◽  
K Channels ◽  
Gating Kinetics ◽  
Inwardly Rectifying ◽  
Kinetics Of

scholarly journals Gating kinetics of the cyclic-GMP-activated channel of retinal rods: flash photolysis and voltage-jump studies.

1988 ◽  
Vol 85 (4) ◽  
pp. 1287-1291 ◽  
Author(s):  
J. W. Karpen ◽  
A. L. Zimmerman ◽  
L. Stryer ◽  
D. A. Baylor
Keyword(s):  
Cyclic Gmp ◽  
Flash Photolysis ◽  
Gating Kinetics ◽  
Retinal Rods ◽  
Kinetics Of ◽  
Voltage Jump

scholarly journals Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers

2010 ◽  
Vol 112 (6) ◽  
pp. 1417-1427 ◽  
Author(s):  
Erik Olofsen ◽  
Eveline van Dorp ◽  
Luc Teppema ◽  
Leon Aarts ◽  
Terry W. Smith ◽  
...  
Keyword(s):  
Treatment Group ◽  
Healthy Volunteers ◽  
Respiratory Depression ◽  
Simulation Study ◽  
Pharmacodynamic Model ◽  
Dissociation Kinetics ◽  
Opioid Agonist ◽  
Respiratory Effect ◽  
End Tidal ◽  
Kinetics Of

Background Opioid-induced respiratory depression is antagonized effectively by the competitive opioid receptor antagonist naloxone. However, to fully understand the complex opioid agonist-antagonist interaction, the effects of various naloxone doses on morphine and morphine-6-glucuronide (M6G)-induced respiratory depression were studied in healthy volunteers. Methods Twenty-four subjects received 0.15 mg/kg morphine intravenously at t = 0 followed by placebo, 200 or 400 microg naloxone at t = 30 min. Thirty-two subjects received 0.3 mg/kg M6G intravenously at t = 0 followed by placebo, 25, 100, or 400 microg naloxone at t = 55 min. There were a total of 8 subjects per treatment group. Respiration was measured on a breath-to-breath basis at constant end-tidal Pco2. A mechanism-based pharmacokinetic-pharmacodynamic model consisting of a part describing biophase equilibration and a part describing receptor association-dissociation kinetics was used to analyze the data. Results Naloxone reversal of M6G-induced respiratory depression developed more slowly than reversal of the respiratory effect of morphine. A simulation study revealed that this was related to the slower receptor association-dissociation kinetics of M6G (koff M6G = 0.0327 +/- 0.00455 min versus morphine 0.138 +/- 0.0148 min; values are typical +/-SE). Duration of naloxone reversal was longer for M6G. This was related to the three- to fourfold greater potency of naloxone as an antagonist against M6G compared with morphine. Increasing the naloxone dose had no effect on the speed of reversal, but it did extend reversal duration. Conclusions Naloxone reversal of the opioid effect is dependent on the receptor association-dissociation kinetics of the opioid that needs reversal with respect to the rate of reversal. The pharmacodynamics of naloxone determines reversal magnitude and duration.

scholarly journals Kinetics of Internal-Loop Formation in Polypeptide Chains: A Simulation Study

2007 ◽  
Vol 92 (7) ◽  
pp. 2281-2289 ◽  
Author(s):  
Dana Doucet ◽  
Adrian Roitberg ◽  
Stephen J. Hagen
Keyword(s):  
Simulation Study ◽  
Loop Formation ◽  
Internal Loop ◽  
Polypeptide Chains ◽  
Kinetics Of
Sign in / Sign up

Export Citation Format

Share Document