scholarly journals Multiple Feature Selection Strategies Identified Novel Cardiac Gene Expression Signature for Heart Failure

2020 ◽  
Vol 11 ◽  
Author(s):  
Dan Li ◽  
Hong Lin ◽  
Luyifei Li
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Feature Selection ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Selection Strategies ◽  
Cardiac Gene Expression ◽  
Multiple Feature ◽  
Cardiac Gene

Abstract 372: Master Transcriptional Regulators of Cardiac Gene Expression in Heart Failure

2018 ◽  
Vol 123 (Suppl_1) ◽  
Author(s):  
Christoph D Rau ◽  
Jessica Wang ◽  
James Ohearn ◽  
Rozeta Avetisyan ◽  
Aldons J Lusis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Transcriptional Regulators ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

scholarly journals CARDIAC GENE EXPRESSION PROFILE DISTINGUISHES AFRICAN-AMERICAN AND EUROPEAN-AMERICAN HEART FAILURE PATIENTS

2016 ◽  
Vol 67 (13) ◽  
pp. 1391
Author(s):  
Indrani Halder ◽  
Victoria Causer ◽  
Charles McTiernan ◽  
Bonnie Lemster ◽  
Ravi Ramani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
African American ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
American Heart ◽  
European American ◽  
Heart Failure Patients ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure

2002 ◽  
Vol 293 (5) ◽  
pp. 1377-1382 ◽  
Author(s):  
Oliver Zolk ◽  
Marcus Frohme ◽  
Alexander Maurer ◽  
Franz-Werner Kluxen ◽  
Bernd Hentsch ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Human Heart ◽  
Protein A ◽  
Negative Regulator ◽  
Human Heart Failure ◽  
Ankyrin Repeat Protein ◽  
Cardiac Gene Expression ◽  
Cardiac Ankyrin Repeat Protein ◽  
Cardiac Gene

Modulation of cardiac gene expression profile by N-3 PUFAs and its implication in hypertrophy and heart failure

2007 ◽  
Vol 42 (6) ◽  
pp. S74
Author(s):  
A. Bordoni ◽  
A. Astolfi ◽  
L. Morandi ◽  
A. Pession ◽  
F. Danesi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

scholarly journals Cardiac gene expression and systemic cytokine profile are complementary in a murine model of post-ischemic heart failure

2010 ◽  
Vol 43 (4) ◽  
pp. 377-389 ◽  
Author(s):  
S. Lachtermacher ◽  
B.L.B. Esporcatte ◽  
F. Montalvão ◽  
P.C. Costa ◽  
D.C. Rodrigues ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Murine Model ◽  
Cytokine Profile ◽  
Ischemic Heart ◽  
Ischemic Heart Failure ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

High-Throughput Transcriptome Analysis Reveals Therapeutic Effects of Statin on Alternations of Cardiac Gene Expression in Heart Failure

2016 ◽  
Vol 22 (9) ◽  
pp. S167
Author(s):  
Atsuyuki Wada ◽  
Takehiro Matsumoto ◽  
Atsushi Taniguchi ◽  
Masanori Fujii ◽  
Masataka Hara ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
High Throughput ◽  
Transcriptome Analysis ◽  
Therapeutic Effects ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

scholarly journals Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure

2019 ◽  
Vol 8 (15) ◽  
Author(s):  
Diana Cruz‐Topete ◽  
Robert H. Oakley ◽  
Natalie G. Carroll ◽  
Bo He ◽  
Page H. Myers ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Glucocorticoid Receptor ◽  
Sexually Dimorphic ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

scholarly journals Cardiac gene expression profile in rats with terminal heart failure and cachexia

2005 ◽  
Vol 20 (3) ◽  
pp. 256-267 ◽  
Author(s):  
Maren Wellner ◽  
Ralf Dechend ◽  
Joon-Keun Park ◽  
Erdenechimeg Shagdarsuren ◽  
Nidal Al-Saadi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Cardiac Hypertrophy ◽  
Expression Profile ◽  
Left Ventricular ◽  
Altered Expression ◽  
Cardiac Gene Expression ◽  
Terminal Heart Failure ◽  
Cardiac Gene ◽  
Blood Pressures

About one-half of double transgenic rats (dTGR) overexpressing the human renin and angiotensinogen genes die by age 7 wk of terminal heart failure (THF); the other (preterminal) one-half develop cardiac damage but survive. Our study’s aim was to elucidate cardiac gene expression differences in dTGR-THF compared with dTGR showing compensated cardiac hypertrophy but not yet THF. dTGR treated with losartan (LOS) and nontransgenic rats (SD) served as controls. THF-dTGR body weight was significantly lower than for all other groups. At death, THF-dTGR had blood pressures of 228 ± 7 mmHg (cardiac hypertrophy index 6.2 ± 0.1 mg/g). Tissue Doppler showed reduced peak early (Ea) to late (Aa) diastolic expansion in THF-dTGR, indicating diastolic function. Preterminal dTGR had blood pressures of 197 ± 5 mmHg (cardiac hypertrophy index 5.1 ± 0.1 mg/g); Ea < Aa compared with LOS-dTGR (141 ± 6 mmHg; 3.7±0.1 mg/g; Ea > Aa) and SD (112 ± 4 mmHg; 3.6 ± 0.1 mg/g; Ea > Aa). Left ventricular RNA was isolated for the Affymetrix system and TaqMan RT-PCR. THF-dTGR and dTGR showed upregulation of hypertrophy markers and α/β-myosin heavy chain switch to the fetal isoform. THF-dTGR (vs. dTGR) showed upregulation of 239 and downregulation of 150 genes. Various genes of mitochodrial respiratory chain and lipid catabolism were reduced. In addition, genes encoding transcription factors (CEBP-β, c-fos, Fra-1), coagulation, remodeling/repair components (HSP70, HSP27, heme oxygenase), immune system (complement components, IL-6), and metabolic pathway were differentially expressed. In contrast, LOS-dTGR and SD had similar expression profiles. These data demonstrate that THF-dTGR show an altered expression profile compared with preterminal dTGR.

The Relationship Between Cardiac Gene Expression and Cardiac Systolic and Diastolic Function in Transition of Cardiac Hypertrophy to Heart Failure

2005 ◽  
Vol 11 (9) ◽  
pp. S292
Author(s):  
Shogo Koshikawa ◽  
Toshio Nishikimi ◽  
Shigeo Horinaka ◽  
Naohiko Kobayashi ◽  
Kimihiko Ishimura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Cardiac Hypertrophy ◽  
Diastolic Function ◽  
Cardiac Gene Expression ◽  
Cardiac Gene ◽  
Systolic And Diastolic Function ◽  
The Relationship
Sign in / Sign up

Export Citation Format

Share Document