scholarly journals Psychometric Properties of the HADS Measure of Anxiety and Depression Among Multiple Sclerosis Patients in Croatia

2021 ◽  
Vol 12 ◽  
Author(s):  
Ana Jerković ◽  
Ana Proroković ◽  
Meri Matijaca ◽  
Jelena Vuko ◽  
Ana Poljičanin ◽  
...  

Depression and anxiety are common complaints in patients with multiple sclerosis (MS). The study objective was to investigate the factor structure, internal consistency, and correlates of the Croatian version of the Hospital Anxiety and Depression Scale (HADS) in patients with MS. A total of 179 patients with MS and 999 controls were included in the online survey. All subjects completed the HADS and self-administered questionnaires capturing information of demographic, education level, disease-related variables, and the Multiple Sclerosis Impact Scale-29 (MSIS-29). Psychometric properties were examined by estimating the validity, reliability, and factor structure of the HADS in patients with MS. The two HADS subscales (anxiety and depression) had excellent internal consistencies (Cronbach’s α value 0.82–0.83), and factor analysis confirmed a two-factor structure. The convergent validity of the HADS subscales appeared to be good due to the significant correlations between HADS and MSIS-29. Receiver operating characteristic (ROC) analysis indicates that the HADS subscales have a significant diagnostic validity for group differentiation. Hierarchical regression analysis using MSIS-29 subscales as criterion variables showed consistent evidence for the incremental validity of the HADS. The HADS is a reliable and valid self-assessment scale in patients with MS and is suggested to be used in clinical monitoring of the psychiatric and psychological status of patients with MS.

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Anne Vinggaard Christensen ◽  
Jane K. Dixon ◽  
Knud Juel ◽  
Ola Ekholm ◽  
Trine Bernholdt Rasmussen ◽  
...  

Abstract Background Anxiety and depression symptoms are common among cardiac patients. The Hospital Anxiety and Depression Scale (HADS) is frequently used to measure symptoms of anxiety and depression; however, no study on the validity and reliability of the scale in Danish cardiac patients has been done. The aim, therefore, was to evaluate the psychometric properties of HADS in a large sample of Danish patients with the four most common cardiac diagnoses: ischemic heart disease, arrhythmias, heart failure and heart valve disease. Methods The DenHeart study was designed as a national cross-sectional survey including the HADS, SF-12 and HeartQoL and combined with data from national registers. Psychometric evaluation included analyses of floor and ceiling effects, structural validity using both exploratory and confirmatory factor analysis and hypotheses testing of convergent and divergent validity by relating the HADS scores to the SF-12 and HeartQoL. Internal consistency reliability was evaluated by Cronbach’s alpha, and differential item functioning by gender was examined using ordinal logistic regression. Results A total of 12,806 patients (response rate 51%) answered the HADS. Exploratory factor analysis supported the original two-factor structure of the HADS, while confirmatory factor analysis supported a three-factor structure consisting of the original depression subscale and two anxiety subscales as suggested in a previous study. There were floor effects on all items and ceiling effect on item 8. The hypotheses regarding convergent validity were confirmed but those regarding divergent validity for HADS-D were not. Internal consistency was good with a Cronbach’s alpha of 0.87 for HADS-A and 0.82 for HADS-D. There were no indications of noticeable differential item functioning by gender for any items. Conclusions The present study supported the evidence of convergent validity and high internal consistency for both HADS outcomes in a large sample of Danish patients with cardiac disease. There are, however, conflicting results regarding the factor structure of the scale consistent with previous research. Trial registration ClinicalTrials.gov: NCT01926145.


Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 111
Author(s):  
Ana Jerković ◽  
Meri Matijaca ◽  
Ana Proroković ◽  
Anđela Šikić ◽  
Vana Košta ◽  
...  

Cognitive impairment is a common complaint in people with multiple sclerosis (pwMS). The study objective was to determine the psychometric properties of the letter digit substitution test (LDST) that measures information processing speed and to investigate the impact of relevant predictors of LDST achievement in pwMS. The design was cross-sectional. The study included 87 pwMS and 154 control subjects. The validity of LDST was examined, and a hierarchical regression model was used to explore relevant predictors of LDST success. The LDST had excellent construct validity, as expressed by differences between pwMS and control subjects. Convergent validity of the LDST was supported by a significant moderate correlation with the expanded disability status scale (EDSS) (ρ = −0.36; p < 0.05) and a significantly strong correlation with the multiple sclerosis impact scale (MSIS-29) physical subscale (r = −0.64; p < 0.01). The LDTS score well differentiated the pwMS considering age, education, EDSS, disease duration, comorbidity, and medication therapy. Using the LDST as a criterion variable in pwMS results showed consistent evidence for the age, education, and EDSS impact on LDST performance. The best cut-off score of ≤35 discriminated the control and MS group. LDST proved to be a valid test for assessing information processing speed in pwMS.


2009 ◽  
Vol 15 (12) ◽  
pp. 1495-1501 ◽  
Author(s):  
Ole-Petter Dahl ◽  
Eystein Stordal ◽  
Stian Lydersen ◽  
Rune Midgard

Anxiety and depression are widely distributed symptoms among multiple sclerosis patients and in the general population. We assessed the prevalence of anxiety and depression in the multiple sclerosis population in Nord-Trøndelag County, Norway compared with Norway’s general population. The Hospital Anxiety and Depression Scale questionnaire was completed by 172 MS patients and 56,000 controls. A cut-off of ≥8 was used to define significant symptoms of anxiety and depression. Fatigue was measured using Krupp’s Fatigue Severity Scale, with a mean cut-off of >4. Among men, 31.1% of the multiple sclerosis patients reported anxiety, while only 12.1% of the control population reported this symptom ( p = 0.002). For women, the prevalence of anxiety was 29.7% versus 17.4% ( p < 0.001). Depression was reported by 26.2% of the men with multiple sclerosis compared with 10.8% of the controls ( p < 0.001). The corresponding figures for women were 25.2% versus 10.4% ( p < 0.001). Anxiety and depression were not correlated with duration of disease or disability measured by the Expanded Disability Status Scale. Among women, fatigue was associated with anxiety ( p ≤ 0.010) and depression ( p = 0.007). No such association was found among men. Anxiety and depression occur more frequently in multiple sclerosis patients than in the general population. Fatigue was associated with these neuropsychiatric manifestations in only women.


2016 ◽  
Vol 18 (4) ◽  
pp. 192-200 ◽  
Author(s):  
Holly A. Parkerson ◽  
Melissa D. Kehler ◽  
Donald Sharpe ◽  
Heather D. Hadjistavropoulos

Background: The Coping with Multiple Sclerosis Scale (CMSS) was developed to assess coping strategies specific to multiple sclerosis (MS). Despite its wide application in MS research, psychometric support for the CMSS remains limited to the initial factor analytic investigation by Pakenham in 2001. Methods: The current investigation assessed the factor structure and construct validity of the CMSS. Participants with MS (N = 453) completed the CMSS, as well as measures of disability related to MS (Multiple Sclerosis Impact Scale), quality of life (World Health Organization Quality of Life Brief Scale), and anxiety and depression (Hospital Anxiety and Depression Scale). Results: The original factor structure reported by Pakenham was a poor fit to the data. An alternate seven-factor structure was identified using exploratory factor analysis. Although there were some similarities with the existing CMSS subscales, differences in factor content and item loadings were found. Relationships between the revised CMSS subscales and additional measures were assessed, and the findings were consistent with previous research. Conclusions: Refinement of the CMSS is suggested, especially for subscales related to acceptance and avoidance strategies. Until further research is conducted on the revised CMSS, it is recommended that the original CMSS continue to be administered. Clinicians and researchers should be mindful of lack of support for the acceptance and avoidance subscales and should seek additional scales to assess these areas.


2009 ◽  
Vol 15 (12) ◽  
pp. 1518-1524 ◽  
Author(s):  
Kimia Honarmand ◽  
Anthony Feinstein

Detecting clinically significant symptoms of depression and anxiety in medically ill patients using self-report rating scales presents a challenge because of somatic confounders. The Hospital Anxiety and Depression Scale (HADS) was developed with this in mind, but has never been validated for a multiple sclerosis population. Our objective was to validate the HADS for multiple sclerosis patients. Multiple sclerosis patients were interviewed for the presence of major depression ( n = 180) and anxiety disorders ( n = 140) with the Structured Clinical Interview for DSM-IV disorders. A receiver operating characteristic (ROC) analysis was undertaken to assess which HADS cut-off scores give the best yield with respect to diagnoses of major depression and all anxiety disorders defined by the Structured Clinical Interview for DSM-IV. A threshold score of 8 or greater on the HADS depression subscale provides a sensitivity of 90% and specificity of 87.3% (ROC area under the curve 0.938). The same cut-off score gives a sensitivity of 88.5% and a specificity of 80.7% on the anxiety subscale (ROC area under the curve 0.913), but for generalized anxiety disorder only. The study confirms the usefulness of the HADS as a marker of major depression and generalized anxiety disorder, but not other anxiety disorders, in multiple sclerosis patients.


2016 ◽  
Vol 37 (1) ◽  
pp. 131-135 ◽  
Author(s):  
Wenjie Duan ◽  
Dan Xie

The Flourishing Scale (FS) is a brief eight-item inventory used to measure psychological well-being. This study evaluated the psychometric properties of the FS in a sample of 766 Chinese adolescents. The paper-and-pencil method was adopted. Confirmatory factor analysis was conducted to examine the factor structure of the FS items. Expanded Satisfaction With Life Scale and Hospital Anxiety and Depression Scale were used to examine the criterion-related and incremental validities. Results showed good internal consistency reliability, one-factor structure, strong convergent validity, and incremental validity of the FS in the current sample. We can conclude that the FS is suitable for use in the Chinese adolescent context.


2015 ◽  
Vol 20 (6) ◽  
pp. 394-399 ◽  
Author(s):  
Erin G. Piker ◽  
David M. Kaylie ◽  
Douglas Garrison ◽  
Debara L. Tucci

Psychiatric comorbidities, particularly anxiety-related pathologies, are often observed in dizzy patients. The Hospital Anxiety and Depression Scale (HADS) is a widely used self-report instrument used to screen for anxiety and depression in medical outpatient settings. The purpose of this study was to assess the factor structure, internal consistency and convergent validity of the HADS in an unselected group of patients with dizziness. The HADS and the Dizziness Handicap Inventory (DHI) were administered to 205 dizzy patients. An exploratory factor analysis was conducted and indicated a 3-factor structure, inconsistent with the 2-subscale structure (i.e. anxiety and depression) of the HADS. The total scale was found to be internally consistent, and convergent validity, as assessed using the DHI, was acceptable. Overall findings suggest that the HADS should not be used as a tool for psychiatric differential diagnosis, but rather as a helpful screener for general psychiatric distress in the two domains of psychiatric illness most germane in dizzy patients.


2021 ◽  
Vol 26 (3) ◽  
pp. 237-247
Author(s):  
Karina Franco-Paredes ◽  
Violeta R. Castro-López

Systematic review of the psychometric properties of the Hospital Anxiety and Depression Scale (HADS)in Mexican samples: Should we go back to the beginning Abstract: A systematic review was run in order to find validation studies on the Hospital Anxiety and Depression Scale (HADS) in Mexican samples. Specialized databases and referencia sections of some articles were searched to locate this evidence. We found 10 articles that analyzed the psychometric properties of the HADS. The analysis showed that in all of the studies reliability was adequate and generally a two-factor structure could be supported. Nevertheless, we identified five different versions of the HADS and did not find any information about the translation process. In conclusion, the adequate internal consistency of the HADS could be confirmed but regarding the two-factor structure and cut-off points evidence is not conclusive. Key words: HADS; reliability; validity; psychometric properties; Mexico. Resumen: El propósito de esta investigación fue realizar una revisión sistemática de los estudios de validación de las propiedades psicométricas de la Escala de Ansiedad y Depresión Hospitalaria (HADS) en muestras mexicanas. Se realizó una búsqueda en bases de datos especializadas y en las referencias de los artículos. Se encontraron 10 estudios en los que se analizaron las propiedades psicométricas de la HADS. El análisis mostró que en todas las invesigaciones se evaluó la fiabilidad y ésta fue adecuada; en general, los estudios apoyan una estructura de dos factores. Sin embargo, se identificaron cinco versiones diferentes de la HADS y no se encontró información sobre cómo se realizó la traducción. En conclusión, se confirma que la consistencia interna de la HADS es adecuada, si bien los estudios apoyan la estructura de dos factores la evidencia no es concluyente, como tampoco lo es respecto a los puntos de corte. Palabras clave: HADS; fiabilidad; validez; propiedades psicométricas; México.


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