scholarly journals FAAH and CNR1 Polymorphisms in the Endocannabinoid System and Alcohol-Related Sleep Quality

2021 ◽  
Vol 12 ◽  
Author(s):  
Soundarya Soundararajan ◽  
Narjis Kazmi ◽  
Alyssa T. Brooks ◽  
Michael Krumlauf ◽  
Melanie L. Schwandt ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Sleep Quality ◽  
Sleep Disturbance ◽  
Sleep Disturbances ◽  
Acid Amide ◽  
Sleep Onset ◽  
Endocannabinoid System ◽  
Sleep Efficiency ◽  
Subjective Sleep Quality

Sleep disturbances are common among individuals with alcohol use disorder (AUD) and may not resolve completely with short-term abstinence from alcohol, potentially contributing to relapse to drinking. The endocannabinoid system (ECS) is associated with both sleep and alcohol consumption, and genetic variation in the ECS may underlie sleep-related phenotypes among individuals with AUD. In this study, we explored the influence of genetic variants in the ECS (Cannabinoid receptor 1/CNR1: rs806368, rs1049353, rs6454674, rs2180619, and Fatty Acid Amide Hydrolase/FAAH rs324420) on sleep quality in individuals with AUD (N = 497) and controls without AUD (N = 389). We assessed subjective sleep quality (from the Pittsburgh Sleep Quality Index/PSQI) for both groups at baseline and objective sleep efficiency and duration (using actigraphy) in a subset of individuals with AUD at baseline and after 4 weeks of inpatient treatment. We observed a dose-dependent relationship between alcohol consumption and sleep quality in both AUD and control groups. Sleep disturbance, a subscale measure in PSQI, differed significantly among CNR1 rs6454674 genotypes in both AUD (p = 0.015) and controls (p = 0.016). Only among controls, neuroticism personality scores mediated the relationship between genotype and sleep disturbance. Objective sleep measures (sleep efficiency, wake bouts and wake after sleep onset), differed significantly by CNR1 rs806368 genotype, both at baseline (p = 0.023, 0.029, 0.015, respectively) and at follow-up (p = 0.004, p = 0.006, p = 0.007, respectively), and by FAAH genotype for actigraphy recorded sleep duration at follow-up (p = 0.018). These relationships suggest a significant role of the ECS in alcohol-related sleep phenotypes.

scholarly journals Actigraphic and Self-reported Sleep in Traffic Accident Victims

2021 ◽  
pp. 1-6
Author(s):  
V. Renner ◽  
M. Keller ◽  
M. Beuth ◽  
W.T. Roth ◽  
K. Petrowski
Keyword(s):  
Sleep Quality ◽  
Traffic Accident ◽  
Sleep Disturbances ◽  
Sleep Onset ◽  
Group Differences ◽  
Sleep State ◽  
Subjective Sleep Quality ◽  
Sleep Log ◽  
Healthy Participants

Background: Some accident victims report poorer sleep during the months after the trauma, which may double the risk for and is a mediator of the development of a PTSD. Furthermore, subjective and objective sleep measures are often discrepant in PTSD-patients, which is why a ‘sleep state misperception’ of PTSD patients is often hypothesized. Objective: The goal of this study is to assess differences in sleep quality in victims of a traffic accident compared to healthy participants without an accident history as well as differences between objective and subjective sleep quality measures. Methods: We recruited 25 hospitalized accident victims within ten days of an accident and 31 age and sex-matched controls without an accident history. Three months later, participants were given a structured clinical interview (SCID), they completed the Pittsburg Sleep Quality Index (PSQI) for the previous two weeks, wore a wrist actigraph, and kept a sleep log for two consecutive nights. Results: At the three-month follow-up, none of the victims met the criteria for any kind of mental disorder, but scored higher on the Posttraumatic Diagnostic Scale. On the PSQI they reported slightly worse sleep than controls for the previous two weeks, although sleep log and actigraphy measures on the two recording nights showed no group differences. Actigraphy measures showed shorter sleep onset latencies compared to log measures. Conclusions: The accident victims suffered only minimal sleep disturbances three months later. The assumption of a ‘sleep state misperception’ in traffic accident victims is questioned by these results.

Cancer-related insomnia: Evaluation by mobile technology.

2015 ◽  
Vol 33 (29_suppl) ◽  
pp. 107-107
Author(s):  
Brenda O'Connor ◽  
Pauline Ui Dhuibhir ◽  
Declan Walsh
Keyword(s):  
Sleep Quality ◽  
Sleep Duration ◽  
Median Duration ◽  
Metastatic Cancer ◽  
Eastern Cooperative Oncology Group ◽  
Sleep Onset ◽  
Severity Index ◽  
Sleep Efficiency ◽  
Subjective Sleep Quality ◽  
Time In Bed

107 Background: Insomnia is difficulty with sleep onset, maintenance, early morning wakening or non-restorative sleep. Cancer prevalence is 30-75%. Daytime consequences include fatigue. It is under-reported and impairs quality of life. Measurement previously required sleep laboratories. Technology advances help real-time measurement in the natural environment. This study investigated the feasibility and acceptability of a wireless device to evaluate sleep in cancer. Methods: Prospective observational study: Stage A: 10 consecutive in-patient hospice admissions; Stage B: 20 consecutive community patients Sleep quality was rated by Insomnia Severity Index (ISI). Participants used a wireless non-contact bedside monitor (SleepMinder) for 3 nights. Acceptability questionnaires were completed by participant and nurse (Stage A) or family (Stage B).Descriptive statistics were generated by Microsoft Excel. Results: 30 participants with metastatic cancer were recruited. Median age: 63 years (47-84). Median Eastern Cooperative Oncology Group (ECOG) performance score: 2 (0-3). In-patient (n=10): In 50%, sleep onset was delayed >30 minutes. Median duration: 8 hours. Median awakenings per night: 1 (0-8). Median sleep efficiency (proportion of time in bed spent asleep): 89% (74-100%). ISI score correlated with sleep duration in 70%. Participants and nurses reported 100% device acceptability. Community (n=20): Sleep onset was delayed >30 minutes in 25%. Median duration: 8 hours. Median awakenings per night: 3 (0-10). Median sleep efficiency: 91% (46-100). ISI score correlated with sleep duration in 90%. Participants and family reported 100% device acceptability. Conclusions: (1)A wireless monitor effectively measures sleep in cancer in both inpatient and community settings, (2) High acceptability supports clinical use, (3) Subjective sleep quality reports correlate with device, and (4) Further research: evaluate sleep improvement interventions with device.

scholarly journals INNV-15. COMPARISON OF READIBAND™ ACTIGRAPH AND ASSOCIATED SLEEP/WAKE CLASSIFICATION ALGORITHMS WITH PATIENT-REPORTED SLEEP QUALITY AND FATIGUE IN GLIOBLASTOMA

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii119-ii119
Author(s):  
Megan Tipps ◽  
Meghan Tierney ◽  
Caitlin Monson ◽  
Kelsey Jackson ◽  
Nilanjana Banerji ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Disease Progression ◽  
Sleep Disturbances ◽  
Clinical Information ◽  
Sleep Efficiency ◽  
Sleep Patterns ◽  
Subjective Sleep Quality ◽  
Ongoing Research ◽  
Efficiency Measures ◽  
Patient Reported

Abstract INTRODUCTION Fatigue and sleep disturbances are among the most common side-effects reported by patients with glioblastoma and contribute significantly to the quality-of-life for this population. Non-invasive monitoring of long-term sleep patterns and fatigue levels in this population would allow for comparison between iatrogenic sleep disturbances, disease progression, treatment tolerance, and self-reported levels of fatigue. Here, we describe initial results from the implementation of the Readiband™ Sleep Tracker (Fatigue Science), a wearable actigraph device, for monitoring sleep patterns and fatigue in patients with newly diagnosed glioblastoma. PATIENTS AND METHODS Patients were prospectively enrolled and asked to wear the Readiband™ Sleep Tracker for a maximum of twelve months or until disease progression. Patients were also asked to report fatigue levels and sleep quality via the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and Pittsburg Sleep Quality Index (PSQI) questionnaires. Demographic, pathologic, and clinical information was abstracted from electronic medical records. RESULTS When data across all participants was combined, FACIT-F and PSQI scores were negatively correlated (r= -0.78, p< 0.001). Significant correlations were also seen between the Readiband™ measures for alertness, sleep quality, and sleep efficiency (p< 0.05 for all). However, we did not observe any correlations between the Redaiband™ measures and subjective survey responses. Interestingly, when patients were sub-divided based on tumor recurrence, we did see significant correlations between both survey scores and sleep quality and sleep efficiency measures (p< 0.05 for all) in patients that recurred during the study period. CONCLUSION The Readiband™ Sleep Tracker is a convenient and viable approach for monitoring sleep and fatigue in glioblastoma patients. Our preliminary findings suggest that actigraph measures may be a better indicator of subjective sleep quality and fatigue levels in specific sub-sets of this population. Ongoing research is exploring other clinical factors that might impact the accuracy of Readiband™ measures.

scholarly journals P008 A systematic review and meta-analysis of inflammatory bowel disease activity and sleep quality

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A24-A24
Author(s):  
A Barnes ◽  
P Spizzo ◽  
R Mountifield ◽  
P Bampton ◽  
J Andrews ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Sleep Quality ◽  
Bowel Disease ◽  
Sleep Onset ◽  
Sleep Efficiency ◽  
Poor Sleep ◽  
Subjective Sleep Quality ◽  
Subjective Sleep ◽  
Inflammatory Bowel ◽  
Meta Analyses

Abstract Background Poor sleep quality has been associated with active inflammatory bowel disease (IBD) in several studies. This review examines sleep quality in people with active IBD and in those in remission, with meta-analyses performed, considering subjective and objective sleep quality and IBD activity. Methods Electronic databases were searched from inception to December 1st 2020. A random effects model was used with separate meta-analyses performed for objective and subjective sleep and IBD activity, considering sleep quality in active and inactive IBD. Results 19 studies were included in the qualitative review representing 4972 IBD patients. Subjective IBD activity (11 studies) was associated with subjective sleep quality with pooled odds ratio (OR) for subjective poor sleep in active IBD compared to remission of 3.04 (95% CI 2.41–3.83). Including only studies with objective sleep measures (5 studies), sleep efficiency was lower in those self-reporting active IBD and time awake post sleep onset was higher in those with active IBD. Objective IBD activity was associated with subjective poor sleep (4 studies), with pooled OR of 6.64 95% CI (3.02 – 14.59). Insufficient data was available to consider objective IBD activity and objective sleep quality. Conclusion IBD activity is associated with poor sleep using subjective and objective measures of sleep quality. This poor sleep manifests as decreased sleep efficiency and increased number of waking episodes post sleep onset. The relationship between objective IBD activity and sleep requires further investigation.

Sleep of Wheelchair Rugby Athletes: Training, Rest and Competition

2020 ◽  
Author(s):  
Victor Sanz-Milone ◽  
Fernanda V. Narciso ◽  
Andressa da Silva ◽  
Milton Misuta ◽  
Marco Túlio de Mello ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Sleep Onset ◽  
Sleep Efficiency ◽  
Sleep Diary ◽  
Poor Sleep ◽  
Subjective Sleep Quality ◽  
Wheelchair Rugby ◽  
Rest Periods ◽  
Rugby Players

AbstractThe aim of this study was to evaluate the sleep-wake cycle of wheelchair rugby athletes during the pre-season compared to in-season. Wheelchair Rugby athletes wore an actigraph monitor during two respective 10-day periods: 1) pre-season and 2) in-season, each of which comprised three training days, three rest days, and four competition days, respectively. In addition, the players completed questionnaires regarding sleepiness, subjective quality of sleep, and chronotype, as well as the use of the sleep diary along with the actigraph measurements (20 days). The wheelchair rugby athletes had poor subjective sleep quality in both stages observed by sleep efficiency below 85% (ES 0.31) and high score in the Pittsburgh questionnaire (effect size-ES 0.55), the actigraphy results presented an increase of sleep latency (ES 0.47), and wake after sleep onset (ES 0.42). When comparing the athlete’s routine, the competition days, demonstrated a reduction in the total time of sleep and the sleep efficiency, in addition to an increase in wakefulness after sleep onset when compared with the training and rest periods. As a result, the wheelchair rugby players did not describe a pattern of sleep-wake cycle during different training phases, as well as poor sleep quality.

Actigraph Estimates of the Sleep of Australian Midwives

2011 ◽  
Vol 15 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Rebecca Tremaine ◽  
Jillian Dorrian ◽  
Jessica Paterson ◽  
Annabelle Neall ◽  
Ellie Piggott ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Sleep Disturbances ◽  
Night Shift ◽  
Sleep Onset ◽  
Subjective Sleep Quality ◽  
Subjective Sleep ◽  
Metropolitan Hospital ◽  
Shift Schedules ◽  
Night Shifts ◽  
Chronic Sleep

Midwives often work night and rotating shift schedules, which can lead to sleep disturbances, increased fatigue, and greater likelihood of accidents or errors. This study investigated the sleep of midwives ( n = 17) in an Australian metropolitan hospital. Midwives completed work and sleep logbooks and wore wrist actigraphs for 28 days. Midwives worked combinations of morning, afternoon, and/or night shifts on constant ( n = 6) or rotating schedules ( n = 11). They obtained less than recommended amounts of sleep, getting only 6–7 hr per 24-hr period. Morning shifts were associated with the lowest sleep durations, lowest subjective sleep quality, and highest postsleep fatigue ratings. Despite the significantly higher amount of wake after sleep onset (51 min), the sleep before afternoon shifts had significantly lower postsleep fatigue ratings and was rated as significantly higher quality than sleep before other shifts or days off. Those who were married or living with a partner reported significantly more sleep and lower postsleep fatigue than those who were separated or divorced ( p < .05). Seventy-one percent of midwives took naps, primarily before night shifts, with nearly 40% of nightshifts preceded by a nap. Average nap durations were nearly 1.5 hr. Midwives reported feeling moderately to very physically or mentally exhausted on 22–50% of all shifts and days off. Exhaustion was most common on night shift. This study suggests that midwives may be suffering from chronic sleep loss and as a consequence may be at risk of impairments in functioning that accompany fatigue.

scholarly journals Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Amanda Rao ◽  
Phillippa Ebelt ◽  
Alistair Mallard ◽  
David Briskey
Keyword(s):  
Sleep Quality ◽  
Sleep Disturbance ◽  
Acid Amide ◽  
Sleep Onset ◽  
Trial Registration ◽  
Sleep Onset Latency ◽  
Double Blind ◽  
Endogenous Fatty Acid ◽  
Wrist Actigraphy ◽  
Wide Range

Abstract Background Sleep is essential for wellbeing, yet sleep disturbance is a common problem linked to a wide range of health conditions. Palmitoylethanolamide (PEA) is an endogenous fatty acid amide proposed to promote better sleep via potential interaction with the endocannabinoid system. Methods This double-blind, randomised study on 103 adults compared the efficacy and tolerability of 8 weeks of daily supplemented PEA formulation (350 mg Levagen + ®) to a placebo. Sleep quality and quantity were measured using wrist actigraphy, a sleep diary and questionnaires. Results At week 8, PEA supplementation reduced sleep onset latency, time to feel completely awake and improved cognition on waking. After 8 weeks, both groups improved their sleep quality and quantity scores similarly. There was no difference between groups at baseline or week 8 for sleep quantity or quality as measured from actigraphy or sleep diaries. Conclusion These findings support PEA as a potential sleeping aid capable of reducing sleep onset time and improving cognition on waking. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12618001339246. Registered 9th August 2018.

scholarly journals Palmitoylethanolamide for Sleep Disturbance. A Double-blind, Randomised, Placebo-controlled Interventional Study

2021 ◽  
Author(s):  
Amanda Rao ◽  
Phillippa Ebelt ◽  
Alistair Mallard ◽  
David Briskey
Keyword(s):  
Sleep Quality ◽  
Sleep Disturbance ◽  
Acid Amide ◽  
Sleep Onset ◽  
Trial Registration ◽  
Sleep Onset Latency ◽  
Double Blind ◽  
Endogenous Fatty Acid ◽  
Wrist Actigraphy ◽  
Wide Range

Abstract Background: Sleep is essential for wellbeing, yet sleep disturbance is a common problem linked to a wide range of health conditions. Palmitoylethanolamide (PEA) is an endogenous fatty acid amide proposed to promote better sleep via potential interaction with the endocannabinoid system.Methods: This double-blind, randomized study on 103 adults compared the efficacy and tolerability of 8 weeks of daily supplemented PEA formulation (350 mg Levagen+TM) to a placebo. Sleep quality and quantity were measured using wrist actigraphy, a sleep diary and questionnaires. Results: At week 8, PEA supplementation reduced sleep onset latency, time to feel completely awake and improved cognition on waking. After 8 weeks, both groups improved their sleep quality and quantity scores similarly. There was no difference between groups at baseline or week 8 for sleep quantity or quality as measured from actigraphy or sleep diaries. Conclusion: These findings support PEA as a potential sleeping aid capable of reducing sleep onset time and improving cognition on waking. Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12618001339246. Registered 9th August 2018, http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=375493&isReview=true

Association of sleep disturbance with diabetic retinopathy

2020 ◽  
pp. 112067212097429
Author(s):  
Somsubhra Dutta ◽  
Sambuddha Ghosh ◽  
Srijit Ghosh
Keyword(s):  
Diabetic Retinopathy ◽  
Sleep Quality ◽  
Sleep Disturbance ◽  
Sleep Disturbances ◽  
Sleep Latency ◽  
Poor Sleep ◽  
Subjective Sleep Quality ◽  
Severe Difficulty ◽  
Normal Sleep ◽  
Internal Homogeneity

Purpose: Diabetes mellitus (DM) patients are more likely to experience sleep disturbances than normal. Sleep disturbances may contribute to the development of diabetic retinopathy (DR) by higher inflammatory markers in circulation. We investigated the association between sleep quality and DR. Methods: Institutional case control study with type 2 DM patients of <10 years duration and HbA1c ⩽8%; 70 cases with DR and 70 controls without DR (NODR) (power 0.8). Sleep quality was assessed by Pittsburg sleep quality index (PSQI) questionnaire and compared. Results: Cronbach’s alpha was 0.777 with high internal homogeneity. Global PSQI score in DR (7.44 ± 3.99; 95%CI 6.88, 9.42) was more than in NODR (4.30 ± 3.26; 95%CI 3.87, 6.45) ( p < 0.001). All sleep disturbance scores were more in DR except sleep duration. Poor sleep (PSQI score>5) was more prevalent in DR ( p = 0.000) and associated with increasing DR severity ( p = 0.026). Normal sleep latency was recorded in 78.57% and 42.85% patients in NODR and DR respectively ( p < 0.001). Severe difficulty in subjective sleep quality ( p = 0.024), sleep latency ( p = 0.002) and daytime dysfunction ( p < 0.001) was seen more in DR. Elevated daytime dysfunction was observed with increasing DR severity ( p = 0.008). The optimal cut-off for global PSQI score and sleep latency for DR was 5.5 (OR: 5.97; 95%CI 2.86, 12.47) and 25 min(OR: 4.89; 95%CI 2.32, 10.26) respectively. Conclusion: Sleep disturbance is positively associated with DR. Our study identifies cut off value for DR of a modifiable parameter like sleep latency. It emphasizes the need of sleep quality assessment for risk assessment of DR.

scholarly journals Sleep Disturbances Are Associated With Depressive Symptoms in a Chinese Population: The Rugao Longevity and Aging Cohort

2021 ◽  
Vol 12 ◽  
Author(s):  
Chunhong Qiao ◽  
Hui Zhang ◽  
Qi Song ◽  
Xi Wang ◽  
Xiaofeng Wang ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Sleep Quality ◽  
Chinese Population ◽  
Sleep Disturbances ◽  
Depression Scale ◽  
Sleep Efficiency ◽  
Cross Sectional ◽  
The Cross ◽  
Older Chinese

Objective: To investigate the cross-sectional and longitudinal relationships between sleep disturbances and depressive symptoms in older Chinese adults.Methods: This study included baseline and 3.5-year follow-up data of 1,631 Chinese men and women aged 70 years or older from the aging arm of the Rugao Longevity and Aging Study. Depressive symptoms were assessed by the 15-item Geriatric Depression Scale (GDS). Sleep disturbances were assessed by using the Pittsburgh Sleep Quality Index (PSQI). Logistic regression models were used to estimate the odds ratios (ORs) of the associations.Results: In the cross-sectional analysis, individuals with greater total PSQI scores exhibited significantly higher risk of “depressive symptoms” (OR: 1.31, 95% CI: 1.21–1.41) and “some depressive symptoms” (OR: 1.22, 95% CI: 1.17–1.28). Specifically, higher scores on the sleep efficiency PSQI subscale were associated with greater odds for “depressive symptoms” (OR: 1.54, 95% CI: 1.30–1.84) and “some depressive symptoms” (OR: 1.42, 95% CI: 1.29–1.57). Our longitudinal analyses indicated an association between greater PSQI total scores at baseline and greater odds of having “some depressive symptoms” at follow-up (OR: 1.07, 95% CI: 1.00–1.14). Additionally, higher scores on the sleep efficiency PSQI subscale had an association with higher odds for “some depressive symptoms” (OR: 1.21, 95% CI: 1.04–1.41).Conclusions: Poor self-reported global sleep quality and sleep efficiency PSQI subscale scores were associated with levels of depressive symptoms in an older Chinese population, indicating that global sleep quality and sleep efficiency may be risk factors for depression and can possibly predict the levels of depressive symptoms.

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