scholarly journals Relating Global Cognition With Upper-Extremity Motor Skill Retention in Individuals With Mild-to-Moderate Parkinson's Disease

2021 ◽  
Vol 2 ◽  
Author(s):  
Jennapher Lingo VanGilder ◽  
Cielita Lopez-Lennon ◽  
Serene S. Paul ◽  
Leland E. Dibble ◽  
Kevin Duff ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Depressive Symptoms ◽  
Task Performance ◽  
Upper Extremity ◽  
Motor Task ◽  
Motor Training ◽  
Global Cognition ◽  
Moca Score

Background and Purpose: Cognition has been linked to rehabilitation outcomes in stroke populations, but this remains unexplored in individuals with Parkinson's disease (PD). The purpose of this secondary data analysis from a recent clinical trial (NCT02600858) was to determine if global cognition was related to skill performance after motor training in individuals with PD.Methods: Twenty-three participants with idiopathic PD completed 3 days of training on an upper-extremity task. For the purposes of the original clinical trial, participants trained either “on” or “off” their dopamine replacement medication. Baseline, training, and 48-h retention data have been previously published. Global cognition was evaluated using the Montreal Cognitive Assessment (MoCA). Linear regression examined whether MoCA score predicted longer-term retention at nine-day follow-up; baseline motor task performance, age, PD severity, depressive symptoms, and group (medication “on”/“off”) were included as covariates. Baseline and follow-up motor task performance were assessed for all participants while “on” their medication.Results: MoCA score was positively related to follow-up motor task performance, such that individuals with better cognition were faster than those with poorer cognition. Baseline task performance, age, PD severity, depressive symptoms, and medication status were unrelated to follow-up performance.Discussion and Conclusions: Results of this secondary analysis align with previous work that suggest cognitive impairment may interfere with motor learning in PD and support the premise that cognitive training prior to or concurrent with motor training may enhance rehabilitative outcomes for individuals with PD. Findings also suggest that assessing cognition in individuals with PD could provide prognostic information about their responsiveness to motor rehabilitation.

scholarly journals Global cognition is related to upper-extremity motor skill retention in individuals with mild-to-moderate Parkinson disease

2021 ◽  
Author(s):  
Jennapher Lingo VanGilder ◽  
Cielita Lopez-Lennon ◽  
Serene S. Paul ◽  
Leland E. Dibble ◽  
Kevin Duff ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cognitive Impairment ◽  
Motor Learning ◽  
Parkinson Disease ◽  
Upper Extremity ◽  
Skill Retention ◽  
Baseline Performance ◽  
Global Cognition ◽  
Moca Score

ABSTRACTBackground and PurposeCognitive impairment has been linked to poor motor learning and rehabilitation outcomes in older adult and stroke populations, but this remains unexplored in individuals with Parkinson disease (PD). The purpose of this secondary data analysis from a recent clinical trial (NCT02600858) was to determine if global cognition was related to nine-day skill retention after upper-extremity motor training in individuals with PD.MethodsTwenty-three participants with idiopathic PD completed three consecutive days of training on an upper-extremity task. For the purposes of the original clinical trial, participants trained either “on” or “off” their dopamine replacement medication. Baseline, training, and shorter-term (48-hour) retention data have been previously published. Global cognition was evaluated using the Montreal Cognitive Assessment (MoCA). Participant age, baseline performance, MoCA score, and group (medication “on”/”off”) were included in a multivariate linear regression model to predict longer-term (nine day) follow-up performance. Baseline and follow-up performance were assessed for all participants while “on” their medication.ResultsMoCA score was positively related to follow-up performance, such that individuals with better cognition performed better than those with poorer cognition. Participant age, baseline performance, and medication status were unrelated to follow-up performance.Discussion and ConclusionsResults of this secondary analysis align with previous work that suggest cognitive impairment may interfere with motor learning in PD, and that assessing cognition could provide prognostic information about an individual’s responsiveness to motor rehabilitation for a number of clinical populations.

scholarly journals Motor task performance under vibratory feedback early poststroke: single center, randomized, cross-over, controled clinical trial

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Vítor Tedim Cruz ◽  
Virgílio Bento ◽  
Luís Ruano ◽  
David Dieteren Ribeiro ◽  
Luís Fontão ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Task Performance ◽  
Motor Task ◽  
Single Center

scholarly journals Dynamic interplay of cognitive functioning and depressive symptoms in patients with Parkinson’s Disease

2021 ◽  
Author(s):  
Ulrich Schroeders ◽  
Johannes Zimmermann ◽  
Tamara Wicke ◽  
Martina Schaumburg ◽  
Elisabeth Lang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Depressive Symptoms ◽  
Cognitive Functioning ◽  
Cognitive Abilities ◽  
Large Variability ◽  
Random Intercept ◽  
Behavioral Enrichment ◽  
Dynamic Interplay

Objective: We examine the trajectories of and the dynamic interplay between cognitive functioning and depressive symptoms in patients with Parkinson's disease (PD) in comparison to healthy controls (HC) from an intraindividual perspective.Method: The DeNoPa study is a single-center, observational, longitudinal study with biennial follow-ups over 8 years. The present analyses are based on 123 PD (79 male) and 107 HC (64 male) with a mean age of 64.1. PD and HC completed a comprehensive battery of neurological tests and scales assessing depressive symptoms. To study their trajectories and the dynamic interplay we used a random-intercept cross-lagged panel model.Results: Cognitive abilities of PD were on average d = -0.56 worse at baseline and d = -0.93 at 8-years follow-up in comparison to HC. Depressive symptoms in PD showed a large variability and followed a U-shaped trajectory. From an intraindividual perspective, stronger impairments in cognitive abilities were subsequently associated with increased depressive symptoms (b = -0.52, p = .01), whereas the effect in the opposite direction was not significant.Conclusions: We found no indication that depressive symptoms can be seen as precursors of dementia. On the contrary, to counter cognitive losses and the subsequent mood deterioration, patient education and early cognitive (and behavioral) enrichment seem promising candidates for treatment.

Effects of dry needling on function, hypertonia and quality of life in chronic stroke: a randomized clinical trial

2021 ◽  
pp. 096452842110563
Author(s):  
Sandra Calvo ◽  
Natalia Brandín-de la Cruz ◽  
Carolina Jiménez-Sánchez ◽  
Elisabeth Bravo-Esteban ◽  
Pablo Herrero
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Upper Extremity ◽  
Chronic Stroke ◽  
Control Group ◽  
Sensorimotor Function ◽  
Single Session ◽  
Dry Needling

Background: Persons with stroke commonly have impairments associated with a reduction in functionality. Motor impairments are the most prevalent, causing an impact on activities of daily life. Objective: The aim of this study was to evaluate the effect of a session of dry needling (DN) applied to the upper extremity muscles on the sensorimotor function, hypertonia, and quality of life of persons with chronic stroke. Methods: A randomized, sham-controlled clinical trial was performed. Participants were randomly assigned into an intervention group that received a single session DN in the biceps brachii, brachialis, flexor digitorum superficialis and profundus, extensor digitorum, adductor pollicis and triceps brachii muscles, or into a control group that received the same treatment but with a sham DN intervention. Treatment outcomes included the Fugl–Meyer Assessment Scale for the upper extremity, the Modified Modified Ashworth Scale, and the EuroQol-5D questionnaire. Measurements were carried out before, immediately after, and 14 days after intervention. Results: Twenty-three persons participated in the study. Significant differences between groups were observed after the intervention in the total wrist–hand motor score (p = 0.023) and sensorimotor score (p = 0.022), for hypertonia in the elbow extensors both after treatment (p = 0.002) and at follow-up (p = 0.018), and in quality of life at follow-up (p = 0.030). Conclusions: A single session of DN improved total wrist–hand motor function and total sensorimotor function in persons with chronic stroke immediately after treatment, as well as quality of life 2 weeks after treatment. Trial registration number: NCT03546517 (ClinicalTrials.gov)

scholarly journals Effect of medication therapy combined with transcranial direct current stimulation on depression and response inhibition of patients with bipolar disorder type I: a clinical trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Parnaz Mardani ◽  
Ahmad Zolghadriha ◽  
Mohsen Dadashi ◽  
Hossein Javdani ◽  
Seyedeh Elnaz Mousavi
Keyword(s):  
Clinical Trial ◽  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Direct Current ◽  
Response Inhibition ◽  
Transcranial Direct Current Stimulation ◽  
Combined Therapy ◽  
Direct Current Stimulation ◽  
Medication Therapy

Abstract Objective Bipolar Disorder (BD) is one of the most common mental disorders associated with depressive symptoms and impairment in executive functions such as response inhibition. This study aimed to investigate the effectiveness of medication therapy combined with Transcranial Direct Current Stimulation (tDCS) on depression and response inhibition of patients with BD. Method This is a double-blinded randomized clinical trial with pretest, posttest, and follow-up design. Participants were 30 patients with BD randomly assigned to two groups of Medication+tDCS (n = 15, receiving medications plus tDCS with 2 mA intensity over dorsolateral prefrontal cortex for 10 days, two sessions per day each for 20 min) and Medication (n = 15, receiving mood stabilizers including 2–5 tables of 300 mg (mg) lithium, 200 mg sodium valproate, and 200 mg carbamazepine two times per day). Pretest, posttest and 3-month follow-up assessments were the 21-item Hamilton Depression Rating Scale (HDRS) and a Go/No-Go test. Collected data were analyzed in SPSS v.20 software. Results The mean HDRS score in both groups was reduced after both interventional techniques, where the group received combined therapy showed more reduction (P < 0.01), although their effects were not maintained after 3 months. In examining response inhibition variable, only the combined therapy could reduce the commission error of patients under a go/no-go task (p < 0.05), but its effect was not maintained after 3 months. There was no significant difference in the group received medication therapy alone. Conclusion Medication in combination with tDCS can reduce the depressive symptoms and improve the response inhibition ability of people with BD. Trial registration This study was registred by Iranian Registry of Clinical Trials (Parallel, ID: IRCT20191229045931N1, Registration date: 24/08/2020).

scholarly journals A Randomized Clinical Trial Showing Persisting Reductions in Depressive Symptoms in HIV-Infected Rural Adults Following Brief Telephone-Administered Interpersonal Psychotherapy

2018 ◽  
Vol 52 (4) ◽  
pp. 299-308 ◽  
Author(s):  
Timothy G Heckman ◽  
John C Markowitz ◽  
Bernadette D Heckman ◽  
Henok Woldu ◽  
Timothy Anderson ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Depressive Symptoms ◽  
Randomized Clinical Trial ◽  
Interpersonal Psychotherapy ◽  
Long Term Follow Up ◽  
Rural Adults

Depressed HIV-infected rural persons who received 9 sessions of telephone-delivered interpersonal psychotherapy (IPT) reported significantly fewer depressive symptoms than non-intervention participants at long-term follow-up.

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