scholarly journals Preliminary Investigation of Bovine Whole Blood Xenotransfusion as a Therapeutic Modality for the Treatment of Anemia in Goats

2021 ◽  
Vol 8 ◽  
Author(s):  
Joe S. Smith ◽  
Austin K. Viall ◽  
Ryan M. Breuer ◽  
Rebecca A. Walton ◽  
Paul J. Plummer ◽  
...  

Anemia requiring whole blood transfusion for appropriate treatment is a common clinical presentation of caprine patients to veterinary practitioners; however, identifying suitable blood donors in goat herds can be challenging. In other veterinary species, the practice of xenotransfusion, where blood from 1 species is transfused to another, is used in emergency settings. Due to their ability to donate large volumes of whole blood, cattle could be an ideal source for xenotransfusion of goats. In this study 2 healthy goats were transfused with bovine whole blood. The goats were then monitored for adverse effects and the presence of bovine erythrocyte post-xenotransfusion. Afterward, 15 caprine–bovine combinations were evaluated for compatibility via cross-matching. Both goats tolerated xenotransfusion, although transient reactions were observed. Of the 15 cross-match combinations, 11 of the major cross matches were compatible, and all minor cross matches were also compatible. While future work is necessary to refine this technique, xenotransfusion of goats with cattle blood may be a therapeutic modality for the treatment of caprine anemia.

Vox Sanguinis ◽  
2021 ◽  
Vol 116 (3) ◽  
Author(s):  
Mindy Goldman ◽  
Mary Townsend ◽  
Karin Magnussen ◽  
Miquel Lozano ◽  
Lise Sofie H. Nissen‐Meyer ◽  
...  

Transfusion ◽  
2011 ◽  
Vol 51 (7) ◽  
pp. 1522-1531 ◽  
Author(s):  
Anne F. Eder ◽  
Beth A. Dy ◽  
Jean M. Kennedy ◽  
Jaime Perez ◽  
Patricia Demaris ◽  
...  

Transfusion ◽  
2021 ◽  
Author(s):  
Christopher R. France ◽  
Janis L. France ◽  
Lina K. Himawan ◽  
Louisa Duffy ◽  
Debra A. Kessler ◽  
...  

2012 ◽  
Vol 1 (1) ◽  
pp. 36-40
Author(s):  
Ghulam Mostafa Khan

Proper selection of donor’s blood group is essential to prevent transfusion hazards. It is known that ABO antigen is fully developed at birth but the newborn baby does not produce ABO antibodies until 3 to 6 months of age. The ABO antibodies present in the serum of newborn babies are derived from mother’s blood due to placental transfer. So the blood group of the newborn baby is done by ABO antigen grouping (forward grouping) only, antibody grouping (reverse grouping) is not required. In case of transfusion of blood in newborn under 4 months of age, cross-matching of donor’s blood is done with the mother’s blood if it is available. We know, recipient’s same group of blood is always preferable in case of transfusion in adults or older children. But selection of blood for transfusion in the infants under 4 months of age depends on the mother’s blood group as well. If the mother’s blood group differs from the infant’s blood group, the infant’s same group of blood may not be selected for transfusion. For example, if the mother’s blood group is “O” and the newborn blood group is “A” or “B”, infant’s same group “A” or “B” group blood could not be transfused, because the anti-A & anti-B antibodies can be derived in the infant’s serum from mother’s blood which may react with the “A” or “B” antigen of the donor’s blood. In this case “O” group packed RBCs should be selected for transfusion. “O” group whole blood may contain IgG anti-A and anti-B antibodies in the plasma which can react with the “A” or “B” antigen of the infant’s blood. So to avoid anti-A & anti-B antibodies in “O” group, plasma should be discarded and the packed RBCs should be transfused. In case of Rh-negative mother with Rh positive baby, Rh antibody may develop in mother’s blood and Rh antibody may enter into baby’s circulation, in this case the infant should be transfused with Rh-negative blood to avoid Rh antigen & antibody reaction. So for the selection of blood for transfusion in newborn baby up to the age of 4 months mother’s blood group is important to select the appropriate blood. DOI: http://dx.doi.org/10.3329/jemc.v1i1.11138J Enam Med Col 2011; 1(1): 36-40


Transfusion ◽  
2013 ◽  
Vol 54 (3pt2) ◽  
pp. 925-932 ◽  
Author(s):  
A. Mireille Baart ◽  
Yvonne Vergouwe ◽  
Femke Atsma ◽  
Karel G.M. Moons ◽  
Wim L.A.M. de Kort
Keyword(s):  

Transfusion ◽  
2001 ◽  
Vol 41 (11) ◽  
pp. 1390-1392 ◽  
Author(s):  
Bruce H. Newman

Author(s):  
Simranjeet Kaur ◽  
Kshitija Mittal ◽  
Ravneet Kaur ◽  
Gagandeep Kaur ◽  
Paramjit Kaur ◽  
...  
Keyword(s):  

Author(s):  
Vinu Rajendran ◽  
Bemma Paonam ◽  
Deepika Chenna ◽  
Ganesh Mohan ◽  
Shamee Shastry ◽  
...  

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