scholarly journals Legacy in Cardiovascular Risk Factors Control: From Theory to Future Therapeutic Strategies?

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1849
Author(s):  
Lucie Pothen ◽  
Jean-Luc Balligand
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Vascular Wall ◽  
Metabolic Memory ◽  
Oxygen Species ◽  
Legacy Effect ◽  
Disease Outcomes ◽  
Control Of Diabetes ◽  
Wall Components

In medicine, a legacy effect is defined as the sustained beneficial effect of a given treatment on disease outcomes, even after cessation of the intervention. Initially described in optimized control of diabetes, it was also observed in clinical trials exploring intensification strategies for other cardiovascular risk factors, such as hypertension or hypercholesterolemia. Mechanisms of legacy were particularly deciphered in diabetes, leading to the concept of metabolic memory. In a more discreet manner, other memory phenomena were also described in preclinical studies that demonstrated long-lasting deleterious effects of lipids or angiotensin II on vascular wall components. Interestingly, epigenetic changes and reactive oxygen species (ROS) appear to be common features of “memory” of the vascular wall.

scholarly journals The Legacy Effect in the Prevention of Cardiovascular Disease

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3227
Author(s):  
Esther Viñas Esmel ◽  
José Naval Álvarez ◽  
Emilio Sacanella Meseguer
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Preventive Treatment ◽  
Patient Characteristics ◽  
Dietary Interventions ◽  
Recent Onset ◽  
Legacy Effect ◽  
Cvd Prevention

The “legacy effect” describes the long-term benefits that may persist for many years after the end of an intervention period, involving different biological processes. The legacy effect in cardiovascular disease (CVD) prevention has been evaluated by a limited number of studies, mostly based on pharmacological interventions, while few manuscripts on dietary interventions have been published. Most of these studies are focused on intensive treatment regimens, whose main goal is to achieve tight control of one or more cardiovascular risk factors. This review aims to summarise the legacy effect-related results obtained in those studies and to determine the existence of this effect in CVD prevention. There is sufficient data to suggest the existence of a legacy effect after intensive intervention on cardiovascular risk factors; however, this effect is not equivalent for all risk factors and could be influenced by patient characteristics, disease duration, and the type of intervention performed. Currently, available evidence suggests that the legacy effect is greater in subjects with moderately-high cardiovascular risk but without CVD, especially in those patients with recent-onset diabetes. However, preventive treatment for CVD should not be discontinued in high-risk subjects, as the level of existing evidence on the legacy effect is low to moderate.

Control of diabetes and cardiovascular risk factors in patients with type 2 diabetes: a nationwide French survey

2003 ◽  
Vol 29 (2) ◽  
pp. 152-158 ◽  
Author(s):  
G Charpentier ◽  
N Genès ◽  
L Vaur ◽  
J Amar ◽  
P Clerson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Control Of Diabetes

scholarly journals Trends and differences between sexes in control of diabetes and cardiovascular risk factors from 2004 to 2014

2016 ◽  
Author(s):  
Almudena Vicente ◽  
Claudia Cortes ◽  
Monica Olivar ◽  
Ana Martinez ◽  
Julia Sastre ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Control Of Diabetes
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