A New Combined Protocol to Treat the Dentin Hypersensitivity Associated with Non-Carious Cervical Lesions: A Randomized Controlled Trial

The goal of this research is to assess the desensitizing effect of a diode laser on non-carious cervical lesions (NCCLs) responsible for dentin hypersensitivity (DH) in two separate output forces implemented both independently and in sequential combination modalities. A randomized controlled trial for this study was applied. Sixty-nine NCCLs responsible for DH pain with severity between 6 and 9 on the VAS scale were considered. Three study groups were developed using just one lesion from three different quadrants of the oral cavity of each patient. All treatment procedures were conducted using a laser diode (810 nm, 5 W) with varying power outputs used separately or in combination. The pain by DH was evaluated at baseline, at treatment completion, and at 15 days and 3 months after each laser procedure. Data analysis was performed using a Wilcoxon test for paired samples, a one-way ANOVA test, and an unpaired t-test. The significant reduction of the mean VAS score was estimated in each study group immediately and at 15 days and 3 months after the end of treatment and compared with the baseline mean VAS score (p-value < 0.0001). The best result concerning the improvement of DH symptomatology was assessed when a combined protocol of two different output powers of the diode laser was used. The authors conclude that the diode laser (810 nm) therapy procedure combining two separate output forces (low and high power) can improve the painful symptoms of DH from NCCLs.

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Low and High output power of 810nm Diode Laser: a new combined protocol to treat the Dentine Hypersensitivity evocated in presence of Non-Carious Cervical lesions.

10.21203/rs.3.rs-49259/v1 ◽

2020 ◽

Author(s):

Felice Femiano ◽

Rossella Femiano ◽

Luigi Femiano ◽

Nicola Scotti ◽

Rossella Sorice

Keyword(s):

Diode Laser ◽

Study Groups ◽

Wilcoxon Test ◽

P Value ◽

Cervical Lesions ◽

Cold Stimulation ◽

Treatment Protocols ◽

Vas Score ◽

Paired Samples ◽

End Of Treatment

Abstract Background The current study evaluates the desensitizing effect of the combination of two different output powers and compares it with single power diode laser.Methods Sixty-nine non carious cervical lesions (NCCLs), responsible of pain by DH after application of test of cold stimulation, were considered for this research. Three study groups were established by analyzing only one lesion in 3 different selected quadrants of the oral cavity in order to obtain a minimum of 3 lesions per patient to treat individually with different therapeutic protocols. All treatment protocols were carried out using a diode laser with different power outcomes used singularly or in combination (810 nm, 5W). The pain by DH was evaluated at baseline, at treatment completion, at 15 days and at 3 months after each laser procedure. Data analysis was performed using Wilcoxon test for paired samples, one-way ANOVA test and unpaired t-test.Results The significant reduction of the mean VAS score has been estimated in each study group immediately, at 15 days and at 3 months’ time from the end of treatment and compared with the baseline mean VAS score (p-value < 0.0001). The best result concerning the improvement of DH symptomatology was assessed when a combined protocol of two different output powers of diode laser was used.Conclusions The author offers a new protocol of laser therapy combining two different output powers of the 810 nm diode laser to improve painful symptoms of DH from NCCL in the short and long term.

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A pilot randomized controlled trial of a tailored smoking cessation program for people living with HIV in the Washington, D.C. metropolitan area

10.21203/rs.3.rs-51334/v1 ◽

2020 ◽

Author(s):

Elexis C. Kierstead ◽

Emily Harvey ◽

Denisse Sanchez ◽

Kimberly Horn ◽

Lorien C. Abroms ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Self Efficacy ◽

Controlled Trial ◽

Study Groups ◽

P Value ◽

People Living With Hiv ◽

Randomized Controlled ◽

Living With Hiv ◽

Pilot Randomized Controlled Trial

Abstract ObjectiveMorbidity and mortality from smoking-related diseases among people living with HIV (PLWH) in the U.S. surpasses that due to HIV itself. Conventional smoking cessation treatments have not demonstrated strong efficacy among PLWH. We conducted a pilot randomized controlled trial (RCT) to evaluate a tailored smoking cessation intervention based on the minority stress model. We compared standard of care counseling (SOC) to a tailored intervention (TI) including one face-to-face counseling session incorporating cognitive behavioral therapy to build resilience, and 30 days of 2-way text messaging.ResultsThe primary outcome was smoking cessation. Secondary outcomes included cigarettes per day (CPD), exhaled carbon monoxide (CO), and cessation self-efficacy. A total of 25 participants were enrolled (TI:11, SOC:14), and 2 were lost to follow up. There were no significant differences in quit rates between study groups. However, there was a significantly greater decrease in CPD in the TI versus SOC (13.5 vs. 0.0, p-value:0.036). Additionally, self-efficacy increased in both groups (TI p-value:0.012, SOC p-value:0.049) and CO decreased in both groups (TI p-value:<0.001, SOC p-value:0.0488). This intervention shows promise to support smoking cessation among PLWH. A larger study is needed to fully evaluate the efficacy of this approach.Trial RegistrationRetrospectively registered (10/20/2020) NCT04594109

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Faculty Opinions recommendation of Indocyanine green-augmented diode laser therapy vs. long-pulsed Nd:YAG (1064 nm) laser treatment of telangiectatic leg veins: a randomized controlled trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718016101.793479147 ◽

2013 ◽

Author(s):

Melvin Chiu

Keyword(s):

Randomized Controlled Trial ◽

Indocyanine Green ◽

Laser Treatment ◽

Laser Therapy ◽

Diode Laser ◽

Controlled Trial ◽

Randomized Controlled

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A pilot randomized controlled trial of a tailored smoking cessation program for people living with HIV in the Washington, D.C. metropolitan area

BMC Research Notes ◽

10.1186/s13104-020-05417-3 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Elexis C. Kierstead ◽

Emily Harvey ◽

Denisse Sanchez ◽

Kimberly Horn ◽

Lorien C. Abroms ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Self Efficacy ◽

Text Messaging ◽

Controlled Trial ◽

P Value ◽

People Living With Hiv ◽

Randomized Controlled ◽

Living With Hiv ◽

Pilot Randomized Controlled Trial

Abstract Objective Morbidity and mortality from smoking-related diseases among people living with HIV (PLWH) in the U.S. surpasses that due to HIV itself. Conventional smoking cessation treatments have not demonstrated strong efficacy among PLWH. We conducted a pilot randomized controlled trial (RCT) to evaluate a tailored smoking cessation intervention based on the minority stress model. We compared standard of care counseling (SOC) to a tailored intervention (TI) including one face-to-face counseling session incorporating cognitive behavioral therapy to build resilience, and 30 days of 2-way text messaging. Results The primary outcome was smoking cessation. Secondary outcomes included cigarettes per day (CPD), exhaled carbon monoxide (CO), and cessation self-efficacy. A total of 25 participants were enrolled (TI:11, SOC:14), and 2 were lost to follow-up. There were no significant differences in quit rates between study groups. However, there was a significantly greater decrease in CPD in the TI versus SOC (13.5 vs. 0.0, p-value:0.036). Additionally, self-efficacy increased in both groups (TI p-value:0.012, SOC p-value:0.049) and CO decreased in both groups (TI p-value: < 0.001, SOC p-value:0.049). This intervention shows promise to support smoking cessation among PLWH. A larger study is needed to fully evaluate the efficacy of this approach. Clinical trial: Trial Registration: Retrospectively registered (10/20/2020) NCT04594109.

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Effect of a breastfeeding educational intervention: a randomized controlled trial

Revista Latino-Americana de Enfermagem ◽

10.1590/1518-8345.3081.3335 ◽

2020 ◽

Vol 28 ◽

Author(s):

Erdnaxela Fernandes do Carmo Souza ◽

Alfredo Almeida Pina-Oliveira ◽

Antonieta Keiko Kakuda Shimo

Keyword(s):

Randomized Controlled Trial ◽

Educational Intervention ◽

Exclusive Breastfeeding ◽

Controlled Trial ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Postpartum Women ◽

Significance Level ◽

Randomized Controlled

Objective: to assess the effect of a breastfeeding educational intervention on the counseling provided to postpartum women. Method: this is a randomized controlled trial including 104 postpartum women (intervention group = 52 and control group = 52) from a private hospital, whose educational intervention was based on the pragmatic theory and on the use of a soft-hard technology called Breastfeeding Educational Kit (Kit Educativo para Aleitamento Materno, KEAM). Women were followed-up for up to 60 days after childbirth. Chi-Squared Test, Fischer’s Exact Test, and Generalized Estimating Equation were used, with a significance level of 5% (p-value <0.05). The analyses were performed using the Statistical Package for the Social Sciences, version 24. Results: the postpartum women in the intervention group had fewer breastfeeding difficulties and a higher percentage of exclusive breastfeeding at all time points compared with those in the control group. Conclusion: the educational intervention based on active methodologies and stimulating instructional resources was effective in developing greater practical mastery among postpartum women with regard to adherence and maintenance of exclusive breastfeeding. Registry REBEC RBR – 8p9v7v.

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Effect of Diode Laser in the Treatment of Patients with Nonspecific Chronic Low Back Pain: A Randomized Controlled Trial

Photomedicine and Laser Surgery ◽

10.1089/pho.2014.3715 ◽

2014 ◽

Vol 32 (9) ◽

pp. 490-494 ◽

Cited By ~ 18

Author(s):

Francesco Vallone ◽

Stefano Benedicenti ◽

Eugenio Sorrenti ◽

Irene Schiavetti ◽

Francesca Angiero

Keyword(s):

Randomized Controlled Trial ◽

Low Back Pain ◽

Back Pain ◽

Diode Laser ◽

Chronic Low Back Pain ◽

Controlled Trial ◽

Low Back ◽

Randomized Controlled

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Clinical Evaluation of self and professionally applied desensitizing agents in relieving dentin hypersensitivity after a single topical application: A Randomized Controlled Trial

Journal of Clinical and Experimental Dentistry ◽

10.4317/jced.51439 ◽

2014 ◽

pp. e339-43 ◽

Cited By ~ 5

Author(s):

SR Samuel ◽

SG Khatri ◽

S. Acharya

Keyword(s):

Randomized Controlled Trial ◽

Clinical Evaluation ◽

Topical Application ◽

Controlled Trial ◽

Dentin Hypersensitivity ◽

Randomized Controlled ◽

Desensitizing Agents

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Healthy Pregnancies Project: Cluster Randomized Controlled Trial of a Community Intervention to Reduce Tobacco Use among Alaska Native Women

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17249302 ◽

2020 ◽

Vol 17 (24) ◽

pp. 9302

Author(s):

Christi A. Patten ◽

Harry A. Lando ◽

Chris A. Desnoyers ◽

Martha J. Bock ◽

Lucinda Alexie ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Usual Care ◽

Tobacco Use ◽

Alaska Native ◽

Controlled Trial ◽

Study Groups ◽

Cluster Randomized Controlled Trial ◽

Community Level ◽

Randomized Controlled ◽

Cluster Randomized

Substantial gaps remain in the evidence base for prenatal tobacco use interventions among Indigenous women. Using a cluster randomized controlled trial (RCT), the Healthy Pregnancies Project evaluated a community-level intervention for Alaska Native (AN) women in rural western Alaska. Sixteen villages were randomly assigned to usual care (control, n = 8 villages) or usual care plus a community-level intervention delivered by local AN “Native Sisters” (n = 8 villages). Outcomes were tobacco use rate at delivery and at 2 and 6 months postpartum, with biochemical confirmation obtained at 6 months. The program had high reach, enrolling 73% of all eligible women screened. Of the 352 participants, 67% used tobacco at baseline. No significant differences emerged between study groups on follow-up in tobacco use rates. More intervention than control participants made a quit attempt at 2 months postpartum (70% vs. 51%, respectively, p = 0.012). Participants in both study groups reported the program helped to raise awareness of healthy pregnancies in the study villages. This trial supports the reach of a community-level intervention, but not its efficacy for reducing tobacco use during pregnancy or postpartum. Efforts to sustain early quit attempts appear warranted. The community involvement, and reported impact on raising awareness of the importance of healthy pregnancies, supports the value of the research program in this community.

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Efficacy of high intensity diode laser as an adjunct to non-surgical periodontal treatment: a randomized controlled trial

Lasers in Medical Science ◽

10.1007/s10103-009-0753-5 ◽

2010 ◽

Vol 26 (1) ◽

pp. 43-48 ◽

Cited By ~ 33

Author(s):

Giorgio De Micheli ◽

Ana Karina Pinto de Andrade ◽

Vanessa Tubero Euzebio Alves ◽

Marcio Seto ◽

Cláudio Mendes Pannuti ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Diode Laser ◽

High Intensity ◽

Controlled Trial ◽

Periodontal Treatment ◽

Randomized Controlled

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Effects of Bupropion on Cognitive Function in Schizophrenia: A Double Blind Randomized Controlled Trial

Global Journal of Health Science ◽

10.5539/gjhs.v9n5p67 ◽

2016 ◽

Vol 9 (5) ◽

pp. 67

Author(s):

Mansoureh Mirzadeh ◽

Najmeh Shahini ◽

Masoud Kashani Lotf Abadi ◽

Maryam Tavakoli ◽

Arash Javanbakht ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Function ◽

Rating Scale ◽

Controlled Trial ◽

Control Group ◽

P Value ◽

Double Blind ◽

Randomized Controlled ◽

Significant Difference ◽

Schizophrenic Patients

Smoking habits are common in schizophrenic patients. Nicotine can suppress negative symptoms and cognitive impairments. The aim of this study was to determine the efficacy of bupropion on cognitive function in schizophrenic patients. This study is a double blind randomized controlled trial in a large referral psychiatric university hospital in Iran. Ninety smoker schizophrenic patients were randomly allocated (based on DSM -IV TR criteria) in two groups (46 patients for case group and 44 patients in control group). They get risperidone up to 6 mg/d and bupropion up to 400 mg/d .clinical assessment (Positive and Negative Syndrome Scale (PANSS), Brief psychiatric rating scale (BPRS) were taken in beginning of study, 14th and 28th days of study. Cognitive assessment (Stroop, Digit Span, and Wechsler, Wisconsin) were taken in begging of study, the days 2nd, 7th, 14th, 28th. All data were analyzed by SPSS Ver. 17 with analytic and descriptive tests. Mean age of patients was 37.66±1.01. Mean duration of disorder was 11.63±.98 years. The scores were significantly lower at the day 28th compared to the beginning of the study in both groups in Wechsler, Stroop color word , Stroop word , Stroop color , BPRS, PANSS p value ≤0.05 .The difference between the two treatments was not significant as indicated by the effect of group, the between-subjects factor p value ≥0.05. In this study, the side effects were examined and there was no significant difference between the two groups p value ≥0.05. Augmentation of bupropion to routine treatment improves cognitive symptoms of schizophrenia in abstinence of tobacco.

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