scholarly journals Targets and Tools: Nucleic Acids for Surface-Enhanced Raman Spectroscopy

Biosensors ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 230
Author(s):  
Irene Calderon ◽  
Luca Guerrini ◽  
Ramon A. Alvarez-Puebla
Keyword(s):  
Raman Spectroscopy ◽  
Nucleic Acids ◽  
Dna Nanotechnology ◽  
Surface Enhanced Raman Spectroscopy ◽  
Optical Signal ◽  
Analytical Tool ◽  
Feature Article ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Structural Dna Nanotechnology

Surface-enhanced Raman spectroscopy (SERS) merges nanotechnology with conventional Raman spectroscopy to produce an ultrasensitive and highly specific analytical tool that has been exploited as the optical signal read-out in a variety of advanced applications. In this feature article, we delineate the main features of the intertwined relationship between SERS and nucleic acids (NAs). In particular, we report representative examples of the implementation of SERS in biosensing platforms for NA detection, the integration of DNA as the biorecognition element onto plasmonic materials for SERS analysis of different classes of analytes (from metal ions to microorgniasms) and, finally, the use of structural DNA nanotechnology for the precise engineering of SERS-active nanomaterials.

Assessment of adenyl residue reactivity within model nucleic acids by surface enhanced Raman spectroscopy

Biopolymers ◽  
2006 ◽  
Vol 82 (1) ◽  
pp. 6-28 ◽  
Author(s):  
Lydie Grajcar ◽  
Chahrazade El Amri ◽  
Mahmoud Ghomi ◽  
Serge Fermandjian ◽  
Valerie Huteau ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Nucleic Acids ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Analytical Potential of Surface-Enhanced Fourier Transform Raman Spectroscopy on Silver Colloids

1993 ◽  
Vol 47 (8) ◽  
pp. 1192-1197 ◽  
Author(s):  
E. Wentrup-Byrne ◽  
S. Sarinas ◽  
P. M. Fredericks
Keyword(s):  
Raman Spectroscopy ◽  
Near Infrared ◽  
Surface Enhanced Raman Spectroscopy ◽  
Preparative Method ◽  
Analytical Tool ◽  
Silver Colloids ◽  
Fourier Transform Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Ft Raman

Although FT-Raman is becoming an increasingly popular analytical tool, it has proved to be relatively insensitive for the analysis of solutions. This is a serious problem, particularly for studies in the biochemical area. Because resonance Raman is not available for near-infrared excitation, surface-enhanced Raman spectroscopy (SERS) provides an important pathway to improved sensitivity. This study is concerned with assessing the potential of SERS with FT-Raman as an analytical tool for aqueous solutions. The SERS effect was investigated for a variety of organic molecules, both nitrogen and non-nitrogen containing, with silver colloids prepared by different literature methods. Various factors were studied: the effect of colloid preparative method, age of the colloid, addition of potassium chloride, time after addition of analyte, and concentration of analyte. In some cases, an analyte gave no SERS effect with a particular colloid, but exhibited a large SERS effect with a colloid prepared by a different method.

scholarly journals Structural Recognition of Triple-Stranded DNA by Surface-Enhanced Raman Spectroscopy

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 326
Author(s):  
Luca Guerrini ◽  
Ramon A. Alvarez-Puebla
Keyword(s):  
Raman Spectroscopy ◽  
Nucleic Acids ◽  
Double Helix ◽  
Surface Enhanced Raman Spectroscopy ◽  
Label Free ◽  
Helix Formation ◽  
Phosphate Backbone ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Triplex Structure

Direct, label-free analysis of nucleic acids via surface-enhanced Raman spectroscopy (SERS) has been continuously expanding its range of applications as an intriguing and powerful analytical tool for the structural characterization of diverse DNA structures. Still, interrogation of nucleic acid tertiary structures beyond the canonical double helix often remains challenging. In this work, we report for the first time the structural identification of DNA triplex structures. This class of nucleic acids has been attracting great interest because of their intriguing biological functions and pharmacological potential in gene therapy, and the ability for precisely engineering DNA-based functional nanomaterials. Herein, structural discrimination of the triplex structure against its duplex and tertiary strand counterparts is univocally revealed by recognizing key markers bands in the intrinsic SERS fingerprint. These vibrational features are informative of the base stacking, Hoogsteen hydrogen bonding and sugar–phosphate backbone reorganization associated with the triple helix formation. This work expands the applicability of direct SERS to nucleic acids analysis, with potential impact on fields such as sensing, biology and drug design.

SERS based detection of multiple analytes from dye/explosive mixtures using picosecond laser fabricated gold nanoparticles and nanostructures

The Analyst ◽  
2019 ◽  
Vol 144 (7) ◽  
pp. 2327-2336 ◽  
Author(s):  
Chandu Byram ◽  
Sree Satya Bharati Moram ◽  
Venugopal Rao Soma
Keyword(s):  
Raman Spectroscopy ◽  
Picosecond Laser ◽  
Surface Enhanced Raman Spectroscopy ◽  
Analytical Tool ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Multiple Analytes ◽  
Analyte Detection ◽  
Non Destructive

Surface enhanced Raman spectroscopy (SERS) is a cutting edge analytical tool for trace analyte detection due to its highly sensitive, non-destructive and fingerprinting capability.

Surface-enhanced Raman spectroscopy: bottlenecks and future directions

2018 ◽  
Vol 54 (1) ◽  
pp. 10-25 ◽  
Author(s):  
Rajapandiyan Panneerselvam ◽  
Guo-Kun Liu ◽  
Yao-Hui Wang ◽  
Jun-Yang Liu ◽  
Song-Yuan Ding ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Future Perspectives ◽  
Future Directions ◽  
Feature Article ◽  
The Past ◽  
Early Stages ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

This feature article discusses developmental bottleneck issues in surface Raman spectroscopy in its early stages and surface-enhanced Raman spectroscopy (SERS) in the past four decades and future perspectives.

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