Surface-enhanced Raman spectroscopy: bottlenecks and future directions

2018 ◽  
Vol 54 (1) ◽  
pp. 10-25 ◽  
Author(s):  
Rajapandiyan Panneerselvam ◽  
Guo-Kun Liu ◽  
Yao-Hui Wang ◽  
Jun-Yang Liu ◽  
Song-Yuan Ding ◽  
...  

This feature article discusses developmental bottleneck issues in surface Raman spectroscopy in its early stages and surface-enhanced Raman spectroscopy (SERS) in the past four decades and future perspectives.

2016 ◽  
Vol 45 (8) ◽  
pp. 2263-2290 ◽  
Author(s):  
Natalie L. Gruenke ◽  
M. Fernanda Cardinal ◽  
Michael O. McAnally ◽  
Renee R. Frontiera ◽  
George C. Schatz ◽  
...  

This review discusses the origins, latest advances, challenges, and future directions of the emerging field of ultrafast surface-enhanced Raman spectroscopy.


Biosensors ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 230
Author(s):  
Irene Calderon ◽  
Luca Guerrini ◽  
Ramon A. Alvarez-Puebla

Surface-enhanced Raman spectroscopy (SERS) merges nanotechnology with conventional Raman spectroscopy to produce an ultrasensitive and highly specific analytical tool that has been exploited as the optical signal read-out in a variety of advanced applications. In this feature article, we delineate the main features of the intertwined relationship between SERS and nucleic acids (NAs). In particular, we report representative examples of the implementation of SERS in biosensing platforms for NA detection, the integration of DNA as the biorecognition element onto plasmonic materials for SERS analysis of different classes of analytes (from metal ions to microorgniasms) and, finally, the use of structural DNA nanotechnology for the precise engineering of SERS-active nanomaterials.


2015 ◽  
Vol 17 (33) ◽  
pp. 21112-21119 ◽  
Author(s):  
Xiaxi Li ◽  
Mingfei Liu ◽  
Jung-pil Lee ◽  
Dong Ding ◽  
Lawrence A. Bottomley ◽  
...  

Thermally robust SERS probes enable the study of coking kinetics on the nickel surface at early stages and at the Ni–YSZ interface.


RSC Advances ◽  
2017 ◽  
Vol 7 (25) ◽  
pp. 14959-14965 ◽  
Author(s):  
Xinxin Yu ◽  
Ranran Cai ◽  
Yuqing Song ◽  
Qiang Gao ◽  
Nan Pan ◽  
...  

During the past decades, researchers have made great efforts towards an ideal surface enhanced Raman spectroscopy (SERS) substrate.


2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.


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