scholarly journals Sensing of C-Reactive Protein Using an Extended-Gate Field-Effect Transistor with a Tungsten Disulfide-Doped Peptide-Imprinted Conductive Polymer Coating

Biosensors ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 31
Author(s):  
Kai-Hsi Liu ◽  
Hung-Yin Lin ◽  
James L. Thomas ◽  
Chen-Yuan Chen ◽  
Yen-Ting Chen ◽  
...  

C-reactive protein (CRP) is a non-specific biomarker of inflammation and may be associated with cardiovascular disease. In recent studies, systemic inflammatory responses have also been observed in cases of coronavirus disease 2019 (COVID-19). Molecularly imprinted polymers (MIPs) have been developed to replace natural antibodies with polymeric materials that have low cost and high stability and could thus be suitable for use in a home-care system. In this work, a MIP-based electrochemical sensing system for measuring CRP was developed. Such a system can be integrated with microfluidics and electronics for lab-on-a-chip technology. MIP composition was optimized using various imprinting template (CRP peptide) concentrations. Tungsten disulfide (WS2) was doped into the MIPs. Doping not only enhances the electrochemical response accompanying the recognition of the template molecules but also raises the top of the sensing range from 1.0 pg/mL to 1.0 ng/mL of the imprinted peptide. The calibration curve of the WS2-doped peptide-imprinted polymer-coated electrodes in the extended-gate field-effect transistor platform was obtained and used for the measurement of CRP concentration in real human serum.

2011 ◽  
Vol 11 (2) ◽  
pp. 1511-1514 ◽  
Author(s):  
Soon Mook Kwon ◽  
Gil Bum Kang ◽  
Yong Tae Kim ◽  
Young-Hwan Kim ◽  
Byeong-Kwon Ju

2016 ◽  
Vol 408 (15) ◽  
pp. 3943-3952 ◽  
Author(s):  
Maria Magliulo ◽  
Donato De Tullio ◽  
Inger Vikholm-Lundin ◽  
Willem M. Albers ◽  
Tony Munter ◽  
...  

2010 ◽  
Vol 8 (2) ◽  
pp. 233-237 ◽  
Author(s):  
Hye-Jung Park ◽  
Sang Kyu Kim ◽  
Kyoungsook Park ◽  
So Yeon Yi ◽  
Jin Woong Chung ◽  
...  

ACS Nano ◽  
2014 ◽  
Vol 8 (10) ◽  
pp. 10396-10402 ◽  
Author(s):  
Xue Liu ◽  
Jin Hu ◽  
Chunlei Yue ◽  
Nicholas Della Fera ◽  
Yun Ling ◽  
...  

2019 ◽  
Vol 6 (11) ◽  
pp. 115909 ◽  
Author(s):  
Muhammad Waqas Iqbal ◽  
Kinza Shahzad ◽  
Ghulam Hussain ◽  
Muhammad Kamran Arshad ◽  
Rehan Akbar ◽  
...  

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