scholarly journals Hopelessness, Dissociative Symptoms, and Suicide Risk in Major Depressive Disorder: Clinical and Biological Correlates

2020 ◽  
Vol 10 (8) ◽  
pp. 519 ◽  
Author(s):  
Mauro Pettorruso ◽  
Giacomo d’Andrea ◽  
Giovanni Martinotti ◽  
Fabrizio Cocciolillo ◽  
Andrea Miuli ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dopamine Transporter ◽  
Psychometric Evaluation ◽  
Inverse Correlation ◽  
Treatment Programs ◽  
Major Depressive ◽  
Psychopathological Symptoms ◽  
Dissociative Symptoms ◽  
Left Caudate

Background: Major depressive disorder (MDD) has different clinical presentations and is associated with neurobiological alterations. Hopelessness, anhedonia, and dissociation represent some of the most pervasive psychopathological symptoms that often lead to suicidal thoughts, attempts, and actions. To further research on the concept of depression endophenotypes, this study aimed to assess the possible relationships between hopelessness and other clinical and biological correlates (i.e., striatal dopaminergic dysfunction) in depressed patients. Methods: We recruited 51 subjects with MDD. All subjects underwent 123I-FP-CIT SPECT to assess striatal dopamine transporter (DAT) availability and a psychometric evaluation using the psychometric scale to assess depressive, anxious, dissociative, and hopelessness symptoms aside from suicidal ideation. Result: An inverse correlation between the hopelessness score and dopamine transporter availability in all basal ganglia was bilaterally found. (Right Putamen, r = −0.445, p < 0.01; Left Putamen, r = −0.454, p < 0.01; Right Caudate, r = −0.398, p < 0.01; Left Caudate, r = −0.467, p < 0.01) Moreover, a positive correlation was also found between hopelessness and dissociative symptoms. Conclusions: These results provide important evidence on the neurobiological and clinical correlates of different psychopathological symptoms of depression with potential implications in terms of devising more effective treatment programs.

scholarly journals Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder

2019 ◽  
Vol 76 (8) ◽  
pp. 854 ◽  
Author(s):  
Diego A. Pizzagalli ◽  
Sabina Berretta ◽  
Dustin Wooten ◽  
Franziska Goer ◽  
Kanoelani T. Pilobello ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dopamine Transporter ◽  
Striatal Dopamine ◽  
Major Depressive

scholarly journals The Quick Inventory of Depressive Symptomatology-Self-report: a psychometric evaluation in patients with asthma and major depressive disorder

2008 ◽  
Vol 100 (5) ◽  
pp. 433-438 ◽  
Author(s):  
E. Sherwood Brown ◽  
Michelle Murray ◽  
Thomas J. Carmody ◽  
Beth D. Kennard ◽  
Carroll W. Hughes ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Depressive Symptomatology ◽  
Psychometric Evaluation ◽  
Self Report ◽  
Major Depressive

scholarly journals Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Yao Yao Li ◽  
Xiao kang Ni ◽  
Ya feng You ◽  
Yan hua Qing ◽  
Pei rong Wang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Gray Matter Volume ◽  
Functional Integration ◽  
Depression Scale ◽  
Neural Mechanism ◽  
Anterior Cingulate ◽  
Treatment Programs ◽  
Hamilton Depression Scale ◽  
Major Depressive

Anxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety. No alterations were observed in the gray matter volume or intra-region functional integration in either patient group. Compared with the controls, both patient groups showed decreased functional connectivity between the left superficial amygdala and the left putamen, and between the right superficial amygdala and the bilateral anterior cingulate cortex and medial orbitofrontal cortex, while only patients with anxiety exhibited decreased activity in the bilateral laterobasal and superficial amygdala. Moreover, the decreased activity correlated negatively with the Hamilton depression scale scores in the patients with anxiety. These findings provided insights into the pathophysiologic processes of anxious major depressive disorder and may help to develop new and effective treatment programs.

Hippocampal subfield volumes in major depressive disorder and bipolar disorder

2019 ◽  
Vol 57 ◽  
pp. 70-77 ◽  
Author(s):  
Kyu-Man Han ◽  
Aram Kim ◽  
Wooyoung Kang ◽  
Youbin Kang ◽  
June Kang ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Molecular Layer ◽  
Inverse Correlation ◽  
Analysis Of Covariance ◽  
Granule Cell Layer ◽  
Uniform Structure ◽  
Major Depressive ◽  
Illness Duration

AbstractBackground:The hippocampus is not a uniform structure, but rather consists of multiple, functionally specialized subfields. Few studies have explored hippocampal subfield volume difference in the same sample of major depressive disorder (MDD) and bipolar disorder (BD) cases. We aimed to investigate the difference of hippocampal subfield volume between patents with MDD and BD and healthy controls (HCs).Methods:A total of 102 MDD and 55 BD patients and 135 HCs were recruited and underwent T1-weighted image. Hippocampal subfield volume was calculated by automated segmentation and volumetric procedures developed by Iglesias et al. and implemented in FreeSurfer. Volume differences between the groups were analyzed using the analysis of covariance and controlling for age, sex, and total intracranial cavity volume.Results:Patients with MDD had significantly reduced volumes in the bilateral cornu ammonis 1 (CA1), CA4, the granule cell layer (GCL), molecular layer (ML), whole hippocampus, the left CA2/3, and right presubiclum and subiculum. Patients with BD had significantly reduced volumes in the right CA1, GCL, and the whole hippocampus as compared to HCs. No significant volume differences were observed between the MDD and BD groups. Illness duration was negatively correlated with volumes of the left CA1, CA4, ML, presubiculum, subiculum, and the whole hippocampus in patients with BD.Conclusion:We observed hippocampal subfield volume reductions in both MDD and BD, a finding which more prominent in MDD. The inverse correlation between BD illness duration and hippocampal subfield volume may evidence the neuroprogressive nature of BD.

scholarly journals Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder

2021 ◽  
Author(s):  
Xue Mei Song ◽  
Xi-Wen Hu ◽  
Zhe Li ◽  
Yuan Gao ◽  
Xuan Ju ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Visual Perception ◽  
Depressive Disorder ◽  
Symptom Severity ◽  
Occipital Cortex ◽  
Higher Order ◽  
Resonance Spectroscopy ◽  
Gaba Concentration ◽  
Major Depressive ◽  
Psychopathological Symptoms

AbstractMajor depressive disorder (MDD) is a complex state-dependent psychiatric illness for which biomarkers linking psychophysical, biochemical, and psychopathological changes remain yet elusive, though. Earlier studies demonstrate reduced GABA in lower-order occipital cortex in acute MDD leaving open its validity and significance for higher-order visual perception, though. The goal of our study is to fill that gap by combining psychophysical investigation of visual perception with measurement of GABA concentration in middle temporal visual area (hMT+) in acute depressed MDD. Psychophysically, we observe a highly specific deficit in visual surround motion suppression in a large sample of acute MDD subjects which, importantly, correlates with symptom severity. Both visual deficit and its relation to symptom severity are replicated in the smaller MDD sample that received MRS. Using high-field 7T proton Magnetic resonance spectroscopy (1H-MRS), acute MDD subjects exhibit decreased GABA concentration in visual MT+ which, unlike in healthy subjects, no longer correlates with their visual motion performance, i.e., impaired SI. In sum, our combined psychophysical-biochemical study demonstrates an important role of reduced occipital GABA for altered visual perception and psychopathological symptoms in acute MDD. Bridging the gap from the biochemical level of occipital GABA over visual-perceptual changes to psychopathological symptoms, our findings point to the importance of the occipital cortex in acute depressed MDD including its role as candidate biomarker.

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