scholarly journals Pathophysiology, Biomarkers, and Therapeutic Modalities Associated with Skeletal Muscle Loss Following Spinal Cord Injury

2020 ◽  
Vol 10 (12) ◽  
pp. 933
Author(s):  
Kelsey P. Drasites ◽  
Ramsha Shams ◽  
Vandana Zaman ◽  
Denise Matzelle ◽  
Donald C. Shields ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Muscle Loss ◽  
Lesion Site ◽  
Secondary Conditions ◽  
Therapeutic Modalities ◽  
Cord Injury ◽  
Skeletal Muscle Loss ◽  
Loss Of Strength

A spinal cord injury (SCI) may lead to loss of strength, sensation, locomotion and other body functions distal to the lesion site. Individuals with SCI also develop secondary conditions due to the lack of skeletal muscle activity. As SCI case numbers increase, recent studies have attempted to determine the best options to salvage affected musculature before it is lost. These approaches include pharmacotherapeutic options, immunosuppressants, physical activity or a combination thereof. Associated biomarkers are increasingly used to determine if these treatments aid in the protection and reconstruction of affected musculature.

scholarly journals The Relationship Between Psychological and Physical Secondary Conditions and Family Caregiver Burden in Spinal Cord Injury: A Correlational Study

2019 ◽  
Vol 25 (4) ◽  
pp. 271-280 ◽  
Author(s):  
Alessio Conti ◽  
Marco Clari ◽  
Maeve Nolan ◽  
Eva Wallace ◽  
Marco Tommasini ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Family Caregivers ◽  
Caregiver Burden ◽  
Functional Independence ◽  
Secondary Conditions ◽  
Care Recipients ◽  
Cord Injury ◽  
Tract Infections ◽  
The Impact

Background: Caregiver burden (CB) is a consequence of providing care to people with spinal cord injury (SCI). However, there is a lack of clarity about the influence of secondary conditions of care recipients on family caregivers. Secondary conditions refer to the physical and psychological complications that can occur after SCI and lead to increased hospitalization and reduced functionality, quality of life, and social participation. Objective: To assess the impact of physical and psychological secondary conditions of people with SCI on the perceived burden of family caregivers. Methods: A multicenter, cross-sectional study of 56 dyads of family caregivers and individuals with SCI in two urban spinal units in Italy and Ireland. Care recipients completed a toolset consisting of demographic information and assessments of functional, physical, and psychological health. Caregivers completed a multidimensional measure of CB. Bivariate data analysis was used. Results: No significant differences between centers were identified. CB was found to be related to physical secondary conditions and functional independence but not to mental health of care recipients. Bladder dysfunction and urinary tract infections influenced all dimensions of CB, whereas pressure injuries influenced only the time-dependent dimension. Level and completeness of injury and duration of caregiving increased CB. Conclusion: Findings indicate the value of a reduction in secondary conditions not just for individuals with SCI but also for their family caregivers. To reduce the individual and family burden of secondary conditions, a two-pronged, multidimensional approach, focusing on self-management for care recipients and psychoeducational support for caregivers, is required.

Secondary conditions in spinal cord injury: Results from a prospective survey

2007 ◽  
Vol 29 (15) ◽  
pp. 1229-1237 ◽  
Author(s):  
Thilo Kroll ◽  
Melinda T. Neri ◽  
Pei-Shu Ho
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Prospective Survey ◽  
Secondary Conditions ◽  
Cord Injury

Intrathecal phenol and glycerin in metrizamide for treatment of intractable spasms in paraplegia

1985 ◽  
Vol 63 (1) ◽  
pp. 125-127 ◽  
Author(s):  
Brett A. Scott ◽  
Zelig Weinstein ◽  
Robert Chiteman ◽  
Morris W. Pulliam
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cerebrospinal Fluid ◽  
Intrathecal Injection ◽  
Fluoroscopic Guidance ◽  
Content Type ◽  
Therapeutic Modalities ◽  
Comparative Review ◽  
Cord Injury ◽  
Fine Print

✓ Intractable lower extremity spasms after spinal cord injury is a significant source of morbidity. A case of refractory spasticity in paraplegia was successfully converted to flaccid paraplegia by intrathecal injection of phenol and glycerin in metrizamide. This chemical rhizolysis is simple and effective, and the presence of metrizamide allows both fluoroscopic guidance for accurate intrathecal phenol placement and good miscibility with cerebrospinal fluid. A brief comparative review of alternative therapeutic modalities is presented.

scholarly journals Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury

2018 ◽  
Vol 223 (3) ◽  
pp. e13051 ◽  
Author(s):  
L. S. Lundell ◽  
M. Savikj ◽  
E. Kostovski ◽  
P. O. Iversen ◽  
J. R. Zierath ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Muscle Atrophy ◽  
Human Skeletal Muscle ◽  
Protein Translation ◽  
Skeletal Muscle Atrophy ◽  
Cord Injury

Bone and muscle loss after spinal cord injury: organ interactions

2010 ◽  
Vol 1211 (1) ◽  
pp. 66-84 ◽  
Author(s):  
Weiping Qin ◽  
William A. Bauman ◽  
Christopher Cardozo
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Muscle Loss ◽  
Cord Injury
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