scholarly journals Elevated Circulating Microparticle Subpopulations in Incidental Cerebral White Matter Hyperintensities: A Multimodal Study

2021 ◽  
Vol 11 (2) ◽  
pp. 133
Author(s):  
Che Mohd Nasril Che Mohd Nassir ◽  
Mazira Mohamad Ghazali ◽  
Amanina Ahmad Safri ◽  
Usman Jaffer ◽  
Wan Zaidah Abdullah ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Diffusion Tensor ◽  
Small Vessel Disease ◽  
Venous Blood ◽  
White Matter Integrity ◽  
Cerebral White Matter ◽  
Blood Collection ◽  
Surrogate Markers ◽  
Neurocognitive Evaluation

Asymptomatic (or “silent”) manifestations of cerebral small vessel disease (CSVD) are widely recognized through incidental findings of white matter hyperintensities (WMHs) as a result of magnetic resonance imaging (MRI). This study aims to examine the potential associations of surrogate markers for the evaluation of white matter integrity in CSVD among asymptomatic individuals through a battery of profiling involving QRISK2 cardiocerebrovascular risk prediction, neuroimaging, neurocognitive evaluation, and microparticles (MPs) titers. Sixty asymptomatic subjects (mean age: 39.83 ± 11.50 years) with low to moderate QRISK2 scores were recruited and underwent neurocognitive evaluation for memory and cognitive performance, peripheral venous blood collection for enumeration of selected MPs subpopulations, and 3T MRI brain scan with specific diffusion MRI (dMRI) sequences inclusive of diffusion tensor imaging (DTI). WMHs were detected in 20 subjects (33%). Older subjects (mean age: 46.00 ± 12.00 years) had higher WMHs prevalence, associated with higher QRISK2 score and reduced processing speed. They also had significantly higher mean percentage of platelet (CD62P)- and leukocyte (CD62L)-derived MPs. No association was found between reduced white matter integrity—especially at the left superior longitudinal fasciculus (LSLF)—with age and neurocognitive function; however, LSLF was associated with higher QRISK2 score, total MPs, and CD62L- and endothelial cell-derived MPs (CD146). Therefore, this study establishes these multimodal associations as potential surrogate markers for “silent” CSVD manifestations in the well-characterized cardiocerebrovascular demographic of relatively young, neurologically asymptomatic adults. Furthermore, to the best of our knowledge, this study is the first to exhibit elevated MP counts in asymptomatic CSVD (i.e., CD62P and CD62L), which warrants further delineation.

scholarly journals Diffusion tensor imaging of cerebral white matter integrity in cognitive aging

2012 ◽  
Vol 1822 (3) ◽  
pp. 386-400 ◽  
Author(s):  
David J. Madden ◽  
Ilana J. Bennett ◽  
Agnieszka Burzynska ◽  
Guy G. Potter ◽  
Nan-kuei Chen ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Cognitive Aging ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
Cerebral White Matter

scholarly journals Thalamic Fractional Anisotropy Predicts Accrual of Cerebral White Matter Damage in Older Subjects with Small-Vessel Disease

2014 ◽  
Vol 34 (8) ◽  
pp. 1321-1327 ◽  
Author(s):  
Michele Cavallari ◽  
Nicola Moscufo ◽  
Dominik Meier ◽  
Pawel Skudlarski ◽  
Godfrey D Pearlson ◽  
...  
Keyword(s):  
White Matter ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Cerebral White Matter ◽  
Mobility Impairment ◽  
Vessel Disease

White matter hyperintensities (WMHs) and lacunes are magnetic resonance imaging hallmarks of cerebral small-vessel disease, which increase the risk of stroke, cognitive, and mobility impairment. Although most studies of cerebral small-vessel disease have focused on white matter abnormalities, the gray matter (GM) is also affected, as evidenced by frequently observed lacunes in subcortical GM. Diffusion tensor imaging (DTI) is sensitive to subtle neurodegenerative changes in deep GM structures. We explored the relationship between baseline DTI characteristics of the thalamus, caudate, and putamen, and the volume and subsequent accrual of WMHs over a 4-year period in 56 community-dwelling older (≤75 years) individuals. Baseline thalamic fractional anisotropy (FA) was an independent predictor of WMH accrual. WMH accrual also correlated with baseline lacune count and baseline WMH volume, the latter showing the strongest predictive power, explaining 27.3% of the variance. The addition of baseline thalamic FA in multivariate modeling increased this value by 70%, which explains 46.5% of the variance in WMH accrual rate. Thalamic FA might serve as a novel predictor of cerebral small-vessel disease progression in clinical settings and trials. Furthermore, our findings point to the possibility of a causal relationship between thalamic damage and the accrual of WMHs.

scholarly journals Venous disruption affects white matter integrity through increased interstitial fluid in cerebral small vessel disease

2020 ◽  
Vol 41 (1) ◽  
pp. 157-165
Author(s):  
Ruiting Zhang ◽  
Peiyu Huang ◽  
Yeerfan Jiaerken ◽  
Shuyue Wang ◽  
Hui Hong ◽  
...  
Keyword(s):  
White Matter ◽  
Interstitial Fluid ◽  
Diffusion Tensor ◽  
Small Vessel Disease ◽  
Free Water ◽  
Cerebral Small Vessel Disease ◽  
White Matter Integrity ◽  
Small Vessel ◽  
White Matter Damage ◽  
Vessel Disease

Deep medullary veins (DMVs) participate in the drainage of surrounding white matter. In cerebral small vessel disease (CSVD), disrupted DMVs were often observed together with damaged white matter, but the phenomenon lacked validation and explanation. We hypothesized that venous disruption might cause white matter damage through increased interstitial fluid resulting from hemodynamic alteration, and we designed a comprehensive multi-modality MRI study to testify our hypothesis. Susceptibility-weighted imaging was used to investigate the characteristics of DMVs and derive DMVs scores. Free water elimination diffusion tensor imaging model was used to analyze interstitial fluid fraction (fraction of free water, fFW) and white matter integrity (tissue fractional anisotropy, FAt). Totally, 104 CSVD patients were included. Total DMVs score was associated with FAt of DMVs drainage area. The effect of total DMVs score on FAt was mediated by fFW, after controlling for age, sex, hypertension, regional cerebral blood flow and lacune numbers. The relationships between DMVs score, fFW and FAt were also significant in most DMVs drainage subregions. Therefore, we discovered the DMVs disruption – increased interstitial fluid – white matter damage link in CSVD patients, which was independent of arterial perfusion variations.

scholarly journals White matter integrity of watershed areas is potentially influenced by hypoperfusion in the presence permanent atrial fibrillation

2021 ◽  
Vol 20 (4) ◽  
pp. 2915
Author(s):  
P. M. Krupenin ◽  
V. A. Perepelov ◽  
E. M. Perepelova ◽  
S. P. Bordovsky ◽  
E. V. Sidorov ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
White Matter ◽  
Statistical Power ◽  
Diffusion Tensor ◽  
Small Vessel Disease ◽  
Mean Diffusivity ◽  
Wilcoxon Test ◽  
White Matter Integrity ◽  
Diffusion Characteristics ◽  
Magnetic Resonance Imaging Mri

Aim. To test a hypothesis of hypoperfusion-induced white matter changes in patients with atrial fibrillation (AFib) and to present statistics to compute sample size for the upcoming studies.Material and methods. We included 30 inpatients with AFib and investigated them with magnetic resonance imaging (MRI) with standard sequencies and diffusion tensor imaging (DTI). DTI data were analyzed with conventional ROI analysis in the Olea Sphere software and with watershed areas (WSA) mask in the FSL toolbox after nonlinear transformation of images to the Montreal Neurological Institute (MNI) space. Wilcoxon test was used to compare diffusion characteristics across subgroups.Results. Median age of participants was 73 years (69-78), 18 (60%) patients had moderate signs of small vessel disease with Fazekas score of one. Twenty-one patients had paroxysmal AFib. Analysis of WSA revealed decreased white matter integrity in the parieto-occipital cortical WSA with a pattern of significantly increased mean diffusivity (p=0,039), and marginally significant decrease in fractional anisotropy (p=0,056). Rank-based effect size across areas under comparison was either small (0,2) or negligible, and with statistical power in the range of 0,05-1.Conclusion. Atrial fibrillation could have pathophysiologically feasible mechanism to affect white matter integrity in the watershed areas. 

scholarly journals GENOME-WIDE ASSOCIATIONS OF AORTIC DISTENSIBILITY SUGGEST CAUSAL RELATIONSHIPS WITH AORTIC ANEURYSMS AND BRAIN WHITE MATTER HYPERINTENSITIES

2021 ◽  
Author(s):  
Catherine M Francis ◽  
Matthias E Futschik ◽  
Jian Huang ◽  
Wenjia Bai ◽  
Muralidharan Sargurupremraj ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Small Vessel Disease ◽  
Aortic Distensibility ◽  
Aortic Aneurysms ◽  
Cerebral White Matter ◽  
Cardiovascular Development ◽  
Aortic Diseases ◽  
Brain White Matter ◽  
Genome Wide

ABSTRACTAortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections, as well as for other cardiovascular and cerebrovascular diseases. We tested genome-wide associations of ascending and descending aortic distensibility and area derived from cardiac magnetic resonance imaging (MRI) data of up to 32,590 Caucasian individuals in UK Biobank. We identified 102 loci (including 31 novel associations) tagging genes related to cardiovascular development, extracellular matrix production, smooth muscle cell contraction and heritable aortic diseases. Functional analyses highlighted four signalling pathways associated with aortic distensibility (TGF-β, IGF, VEGF and PDGF). We identified distinct sex-specific associations with aortic traits. We developed co-expression networks associated with aortic traits and applied phenome-wide Mendelian randomization (MR-PheWAS), generating evidence for a causal role for aortic distensibility in development of aortic aneurysms. Multivariable MR suggested a causal relationship between aortic distensibility and cerebral white matter hyperintensities, mechanistically linking aortic traits and brain small vessel disease.

Sign in / Sign up

Export Citation Format

Share Document